Environmental Health

Table 6 Ratios of the FD&C Red No. 3 intake compared with US FDA and JECFA ADIs

From: Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence

FD&C Red No. 3	Typical-exposure scenario				High-exposure scenario
FD&C Red No. 3	FDA Ratio Mean	FDA Ratio 95th%	JECFA Ratio Mean	JECFA Ratio 95th%	FDA Ratio Mean	FDA Ratio 95th%	JECFA Ratio Mean	JECFA Ratio 95th%
Pregnant women
Day 1	0.01	0.09	0.29	2.28	0.02	0.27	0.60	6.66
Day 2	0.008	0.02	0.20	0.41	0.01	0.02	0.23	0.54
2 -Day average	0.008	0.05	0.20	1.14	0.01	0.13	0.35	3.33
Women 18–49 years
Day 1	0.01	0.03	0.27	0.78	0.02	0.03	0.38	0.81
Day 2	0.01	0.04	0.29	1.02	0.02	0.04	0.38	1.02
2 -Day average	0.01	0.03	0.18	0.72	0.01	0.03	0.24	0.80
Children (0- < 2 years)
Day 1	0.01	0.04	0.28	0.90	0.01	0.04	0.32	1.11
Day 2	0.21	1.93	5.35	48.3	0.60	3.16	15.0	79.0
2-Day average	0.07	0.03	1.73	0.68	0.19	0.03	4.72	0.68
Children (2- < 5 years)
Day 1	0.08	0.07	1.89	1.85	0.19	0.08	4.85	1.90
Day 2	0.02	0.06	0.56	1.56	0.03	0.07	0.84	1.68
2-Day average	0.03	0.04	0.70	0.90	0.07	0.04	1.66	0.90
Children (5- < 9 years)
Day 1	0.03	0.04	0.64	1.12	0.04	0.06	1.05	1.38
Day 2	0.04	0.08	1.09	1.98	0.07	0.09	1.72	2.14
2-Day average	0.02	0.05	0.62	1.22	0.04	0.09	0.98	2.28
Children (9- < 16 years)
Day 1	0.03	0.06	0.87	1.61	0.08	0.13	1.96	3.19
Day 2	0.03	0.06	0.87	1.38	0.06	0.06	1.52	1.44
2-Day average	0.02	0.06	0.55	1.60	0.04	0.17	1.05	4.21
Youth (16–18 years)
Day 1	0.02	0.09	0.49	2.14	0.03	0.09	0.69	2.14
Day 2	0.007	0.02	0.17	0.57	0.01	0.03	0.21	0.80
2-Day average	0.007	0.02	0.18	0.54	0.01	0.02	0.24	0.62

US Food and Drug Administration (US FDA ADI = 2.5 mg/kg/day)
JECFA Joint FAO/WHO Expert Committee on Food Additives (JECFA ADI = 0.1 mg/kg/day)

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