Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)

Table 3 Association between Air pollutants concentrations (μg/m³) and thyroid hormones levels (TSH, FT4, FT3)

	TSH	p	FT4	p	FT3	p
	% change (95% CI)	p	% change (95% CI)	p	% change (95% CI)	p
PM_2.5
Crude	0.2 (-0.8. 1.2)	0.767	-0.5 (-0.7 .-0.3)	<0.001	-0.7 (-1.0. -0.5)	<0.001
Multivariate	0.2 (-0.8. 1.3)	0.664	-0.5 (-0.8 .-0.8)	<0.001	-0.9 (-1.2. -0.7)	<0.001
NO₂
Crude	-0.3 (-1.1. 0.4)	0.403	-0.2 (-0.4. 0.0)	0.067	-0.1 (-0.3. 0.1)	0.234
Multivariate	-0.5 (-1.3. 0.4)	0.278	-0.2 (-0.4. 0.0)	0.118	-0.1 (-0.3. 0.1)	0.367

% changes and p values calculated by linear regression per interquartile range (IQR) increase in air pollutants concentrations (PM_2.5: 4.86 μg/m³, NO₂: 12.62 μg/m³)
In bold: ß coefficients with p values <0.05
^#Multivariate model: Adjusted to age, sex, urinary iodine, BMI, education level, smoking status and ambient temperature
PM_2.5 Particles with an aerodynamic diameter of less than 2.5 microns, NO₂ Nitrogen dioxide

ISSN: 1476-069X