Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years

Kupsco, Allison; Sjödin, Andreas; Cowell, Whitney; Jones, Richard; Oberfield, Sharon; Wang, Shuang; Hoepner, Lori A.; Gallagher, Dympna; Baccarelli, Andrea A.; Goldsmith, Jeff; Rundle, Andrew G.; Herbstman, Julie B.

doi:10.1186/s12940-022-00893-5

Environmental Health

Table 4 Associations between high cord plasma PBDE concentrations and trajectories of child BMI z-score from 5 to 14 years

From: Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years

Predictor Variables	Beta Coefficient (95% Confidence Interval)^ab
Predictor Variables	Model 1^b	Model 2^c
BDE-47
BDE-47 ≥78 ng/mL	−0.36 (− 0.69, − 0.02)**	−0.21 (− 0.54, 0.12)
Centered Age	0.12 (0.07, 0.16)***	0.12 (0.07, 0.16)***
Centered Age^2	− 0.01 (− 0.02, − 0.01)***	−0.01 (− 0.02, − 0.01)***
BDE-47*Centered Age	0.02 (− 0.09, 0.12)	0.02 (− 0.09, 0.12)
BDE-47*Centered Age^2	− 0.01 (− 0.02, 0.01)	− 0.01 (− 0.02, 0.01)
BDE-99
BDE-99 ≥16.8 ng/mL	− 0.22 (− 0.56, 0.12)	0.02 (− 0.32, 0.36)
Centered Age	0.13 (0.08, 0.17)***	0.13 (0.08, 0.17)***
Centered Age^2	−0.01 (− 0.02, − 0.01)***	−0.01 (− 0.02, − 0.01)***
BDE-99*Centered Age	−0.04 (− 0.14, 0.07)	−0.04 (− 0.15, 0.07)
BDE-99*Centered Age^2	0.003 (− 0.01, 0.02)	0 (− 0.01, 0.02)
BDE-100
BDE-100 ≥10.5 ng/mL	−0.15 (− 0.48, 0.19)	−0.03 (− 0.36, 0.31)
Centered Age	0.14 (0.09, 0.19) ***	0.14 (0.09, 0.19) ***
Centered Age^2	−0.02 (− 0.02, − 0.01) ***	−0.02 (− 0.02, − 0.01) ***
BDE-100*Centered Age	−0.1 (− 0.2, 0.01)*	−0.1 (− 0.2, 0.01)*
BDE-100*Centered Age^2	0.02 (0, 0.03)*	0.02 (0, 0.03)*
BDE-153
BDE-153 ≥8.67 ng/mL	−0.37 (− 0.71, − 0.03)**	−0.16 (− 0.52, 0.21)
Centered Age	0.13 (0.08, 0.17)***	0.13 (0.08, 0.17) ***
Centered Age^2	−0.02 (− 0.02, − 0.01)***	−0.02 (− 0.02, − 0.01)***
BDE-153*Centered Age	−0.05 (− 0.15, 0.06)	−0.05 (− 0.15, 0.06)
BDE-153*Centered Age^2	0.01 (0, 0.03)	0.01 (0, 0.03)
ΣPBDE
Σ PBDE ≥ 112 ng/mL	−0.33 (− 0.67, 0.01)*	−0.18 (− 0.52, 0.16)
Centered Age	0.12 (0.07, 0.16)***	0.12 (0.07, 0.16)***
Centered Age^2	−0.01 (− 0.02, − 0.01***	−0.01 (− 0.02, − 0.01)***
Σ PBDE*Centered Age	0.02 (− 0.09, 0.12)	0.01 (− 0.09, 0.12)
Σ PBDE*Centered Age^2	0.004 (− 0.02, 0.01)	0 (− 0.02, 0.01)

^aBeta coefficients are interpreted as the change in BMI Z-score when each PBDE is increased from low (< 80th percentile) to high (>80th percentile) when age is increased by one year
^bModel 1: Minimally adjusted for age and age² (centered at age 5) and sex
^cModel 2: Fully adjusted for maternal parity (primiparous/multiparous), age at birth, ethnicity (Dominican/African American), receipt of public assistance (yes/no), completed high school (yes/no), partnership status (partnered/single), and linear and quadratic child age at visit (centered at age 5) and child sex
^bP-value Thresholds: ***P ≤ 0.001; **P ≤ 0.05, *P ≤ 0.1

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