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Table 3 Adjusteda cumulative hazard ratios (HRs) and 95% confidence intervals (CIs) of gestational diabetes per interquartile range (IQR) increase in PM2.5 and O3 for the DLM-identified sensitive windows, stratified by potential effect modifiers

From: Critical windows of exposure to air pollution and gestational diabetes: assessing effect modification by maternal pre-existing conditions and environmental factors

Potential effect modifiers

PM2.5

7th to 18th weeks of gestation

O3

Preconception weeks

O3

9th to 28th weeks of gestation

HR (95% CI)

HR (95% CI)

HR (95% CI)

Asthma

 Presence

1.21 (1.05 – 1.35)

0.96 (0.88 – 1.04)

1.12 (1.07 – 1.15)

 Absence

1.06 (1.01 – 1.10)

1.03 (1.01 – 1.06)

1.04 (1.01 – 1.07)

P value for effect modification

0.099

0.331

0.041

Chronic hypertension

 Presence

0.95 (0.80 – 1.14)

0.96 (0.86 – 1.08)

1.03 (0.88 – 1.21)

 Absence

1.07 (1.02 – 1.11)

1.00 (0.99 – 1.02)

1.08 (1.04 – 1.12)

P value for effect modification

0.754

0.852

0.842

NDVI

 1st tertile

1.10 (1.06 – 1.14)

1.01 (0.98 – 1.04)

1.05 (1.02 – 1.09)

 2nd tertile

1.07 (1.02 – 1.11)

1.03 (1.01 – 1.06)

1.08 (1.04 – 1.12)

 3rd tertile

1.04 (1.00 – 1.08)

1.00 (0.98 – 1.03)

1.04 (1.01 – 1.06)

P value for effect modification

0.423

0.732

0.891

GVI

 1st tertile

1.12 (1.07 – 1.16)

1.00 (0.97 – 1.03)

1.02 (0.98 – 1.06)

 2nd tertile

1.06 (1.02 – 1.10)

1.01 (0.98 – 1.04)

1.06 (1.02 – 1.10)

 3rd tertile

1.07 (1.02 – 1.11)

1.03 (1.00 – 1.06)

1.09 (1.04 – 1.13)

P value for effect modification

0.521

0.789

0.652

Active Living Environment

 1st tertile

1.06 (1.01 – 1.10)

1.00 (0.97 – 1.04)

1.03 (0.99 – 1.07)

 2nd tertile

1.02 (0.98 – 1.06)

1.01 (0.99 – 1.04)

1.06 (1.02 – 1.10)

 3rd tertile

1.12 (1.08 – 1.16)

1.03 (1.00 – 1.05)

1.08 (1.04 – 1.12)

P value for effect modification

0.489

0.921

0.356

  1. aAdjusted for maternal age, parity, maternal smoking status, prepregnancy body mass index, weekly ambient temperatures, month of birth, year of birth, residing in the Greater Toronto Area, community size, deprivation quintiles, instability quintiles, dependency quintiles and ethnic quintiles