Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution

Table 6 Gene-environment interactions between pollutant exposure and genotypes on FeNO270 estimated from single and multipollutant quantile regression models (75^th percentile)

SNP	Pollutant (exposure window)	Single pollutant				Multi pollutant
SNP	Pollutant (exposure window)	p-value^a	Marginal effect coefficient (95%CI)			p-value^a	Marginal effect coefficient (95%CI)
rs4253527^b (SFTPA1) (n = 3052)	O₃ (3 h)	0.029	CC -0.015 (-0.088, 0.058)	TC/TT 0.155 (0.013, 0.297)		0.019	CC -0.028 (-0.125, 0.069)		TC/TT 0.142 (-0.014, 0.299)
rs4253527^b (SFTPA1) (n = 3052)	NO_x (3 h)	0.050	CC 0.009 (-0.012, 0.029)	TC/TT -0.0371 (-0.078, 0.004)		0.089	CC 0.027 (-0.018, 0.072)		TC/TT -0.014 (-0.075, 0.046)
rs4796017^c (NOS2) (n = 3378)	PM₁₀ (120 h)	0.047 (GG)	AA -0.091 (-0.394, 0.212)	GA -0.125 (-0.371, 0.121)	GG 0.396 (0.003, 0.790)	0.077 (GG)	AA -0.032 (-0.362, 0.297)	GA -0.040 (-0.318, 0.238)	GG 0.404 (-0.011, 0.819)

All 3-h interaction analyses are adjusted for age, height, year, month, current cold, and atopy. All 24- and 120-h interaction analyses are adjusted for age, height, year, month, current cold, atopy, and temperature. All estimates are given per 10 µg/m³ increase in air pollutant exposure
^ap-value for interaction term. For additive models the genotype with significant difference from the major allele genotype is presented in parentheses
^bDominant model
^cAdditive model

ISSN: 1476-069X