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Table 3 Association of PFAS concentrations in umbilical cord blood plasma with children BP in Early childhood

From: Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study

 

SBP

DBP

MAP

PP

 

Crude model

Model 1

Model 2

Crude model

Model 1

Model 2

Crude model

Model 1

Model 2

Crude model

Model 1

Model 2

PFDA

-2.91(-5.52,-0.28)

-3.30(-6.04,-0.51)

-2.50(-5.14,0.16)

-2.24(-4.43,0.00)

-2.33(-4.63,-0.06)

-2.31(-4.56,-0.06)

-2.41(-4.45,-0.40)

-2.63(-4.78,-0.53)

-2.30(-4.42,-0.22)

-0.68(-3.04,1.68)

-0.93(-3.41,1.56)

-0.18(-2.51,2.15)

PFDoA

2.16(-0.45,4.77)

1.91(-0.84,4.65)

2.08(-0.56,4.71)

1.34(-0.87,3.56)

1.08(-1.19,3.34)

1.15(-1.11,3.41)

1.16(-0.88,3.20)

0.94(-1.18,3.07)

1.06(-1.05,3.18)

0.82(-1.52,3.15)

0.83(-1.60,3.26)

0.92(-1.38,3.22)

PFHpA

4.15(0.43,7.83)

4.12(0.20,8.09)

3.24(-0.58,7.06)

2.91(-0.23,6.05)

2.34(-0.94,5.61)

2.29(-0.98,5.55)

2.71(-0.18,5.60)

2.46(-0.60,5.53)

2.04(-1.03,5.11)

1.22(-2.12,4.55)

1.81(-1.72,5.33)

0.95(-2.39,4.30)

PFHxS

-1.18(-3.17,0.81)

-1.16(-3.21,0.89)

-1.46(-3.42,0.51)

-0.21(-1.90,1.48)

-0.44(-2.13,1.25)

-0.61(-2.30,1.07)

-0.11(-1.66,1.44)

-0.17(-1.76,1.42)

-0.42(-2.00,1.16)

-0.97(-2.73,0.79)

-0.71(-2.52,1.09)

-0.84(-2.55,0.87)

PFNA

-2.25(-5.22,0.72)

-2.41(-5.52,0.70)

-2.18(-5.11,0.76)

-1.67(-4.18,0.84)

-1.83(-4.39,0.73)

-2.00(-4.50,0.49)

-2.06(-4.35,0.23)

-2.28(-4.67,0.10)

-2.27(-4.59,0.06)

-0.58(-3.23,2.07)

-0.58(-3.34,2.18)

-0.18(-2.74,2.39)

PFOA

-1.39(-4.25,1.46)

-1.27(-4.20,1.66)

-1.63(-4.43,1.17)

-0.66(-3.08,1.76)

-0.45(-2.87,1.96)

-0.76(-3.15,1.64)

-0.79(-3.01,1.44)

-0.66(-2.93,1.61)

-1.04(-3.29,1.20)

-0.73(-3.27,1.80)

-0.82(-3.40,1.77)

-0.87(-3.30,1.56)

PFOS

-3.69(-5.79,-1.56)

-3.84(-6.06,-1.61)

-3.10(-5.20,-0.89)

-2.45(-4.30,-0.67)

-2.27(-4.13,-0.38)

-2.15(-4.04,-0.33)

-2.33(-4.02,-0.69)

-2.31(-4.08,-0.58)

-1.96(-3.72,-0.24)

-1.19(-3.14,0.76)

-1.58(-3.62,0.45)

-0.86(-2.79,1.07)

PFUA

-3.05(-5.77,-0.36)

-3.64(-6.54,-0.78)

-2.49(-5.33,0.34)

-2.52(-4.83,-0.27)

-2.72(-5.12,-0.37)

-2.48(-4.91,-0.11)

-2.50(-4.56,-0.37)

-2.75(-5.02,-0.58)

-2.16(-4.42,0.09)

-0.52(-2.96,1.93)

-0.91(-3.52,1.69)

0.02(-2.47,2.50)

PFBS

5.99(-1.53,13.51)

5.99(-1.77,13.75)

3.28(-4.28,10.84)

-0.59(-6.99,5.82)

-0.89(-7.32,5.55)

-0.89(-7.35,5.57)

2.10(-3.78,7.98)

1.94(-4.10,7.98)

0.77(-5.29,6.83)

6.58(-0.04,13.19)

6.84(0.10,13.65)

4.17(-2.35,10.68)

  1. Multiple linear regression models were used and adjusted for maternal and offspring factors
  2. Model 1: adjusted for household income, educational levels, GDM, HDP, drinking history, passive smoking history and age of mom
  3. Model 2: Model 1 + birthweight, sex and BMI of children
  4. PFOA: perfluorooctanate, PFOS: perfluorooctane sulfonate, PFNA: perfluorononanoic acid, PFDA: perfluorodecanoic acid, PFUA: perfluoroundecanoic acid, PFHxS: perfluorohexanesulfonate, PFHpA: perfluoroheptanoic acid, PFDoA: perfluorododecanoic acid, PFBS: perfluorobutane sulfonate; BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, MAP: mean artery pressure, PP: pulse pressure, HDP: hypertensive disorders in pregnancy, GDM: gestational diabetes mellitus