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Fig. 6 | Environmental Health

Fig. 6

From: Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines

Fig. 6

ΔΨm increases in Ishikawa, but not HEC-1, cells following exposure to PFAS or PFAS mixtures + cisplatin treatment. a Timeline of experiments. In HEC-1 cells, ΔΨm was unchanged compared to the vehicle control in all groups exposed to (b,d,f) PFAS and (h) PFAS mixtures then treated with cisplatin. ΔΨm increased in Ishikawa cells exposed to (c) PFOA, (e) PFHpA, and (i) PFAS mixtures. No changes in ΔΨm were observed in Ishikawa cells exposed to (g) PFPA. Data are shown as a percentage of the vehicle control at each cisplatin level; n = 3 or 4 independent experiments in duplicate for HEC-1 cells, n = 4 independent experiments for Ishikawa cells. Significant differences between PFAS/PFAS mixture + carboplatin treatment group versus vehicle group at each respective cisplatin dose are denoted by * (p < 0.05)

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Environmental Health

ISSN: 1476-069X