Air pollutionb | CAD PRS (tertiles)c | Â |
|---|
Intermediatea | Higha |
|---|
RERI (95% CI) | AP (95% CI) | RERI (95% CI) | AP (95% CI) |
|---|
PM2.5 |
 High pollution | 0.26 (0.20, 0.32) | 0.28 (0.22, 0.33) | 0.12 (0.05, 0.19) | 0.09 (0.04, 0.14) |
PM10 |
 High pollution | 0.23 (0.17, 0.29) | 0.25 (0.19, 0.31) | 0.17 (0.10, 0.24) | 0.12 (0.07, 0.18) |
NO2 |
 High pollution | 0.29 (0.24, 0.35) | 0.31 (0.26, 0.36) | 0.14 (0.07, 0.21) | 0.11 (0.06, 0.16) |
NOx |
 High pollution | 0.30 (0.25, 0.36) | 0.32 (0.27, 0.37) | 0.17 (0.10, 0.24) | 0.13 (0.08, 0.18) |
- Adjusted for age (continuous), sex (male/female), alcohol consumption (never, previous, current, missing), smoking status (never, previous, current, missing), body mass index (< 25 kg/m2, 25 to 29.9 kg/m2, ≥ 30 kg/m2, missing), education level (College or University degree, A/AS-level, O-level/GCSE, CSE, NVQ/HND/HNC, other qualifications, none), UK Biobank assessment center, physical activity (continuous, MET-min/week), diabetes at baseline (yes/no), cardiovascular disease at baseline (yes/no), genotyping batch, and the first 4 genetic principal components
- RERI relative excess risk due to interaction, AP attributable proportion due to interaction, CI confidence interval, PRS polygenic risk score, CAD coronary artery disease, PM2.5, fine particulate matter with diameter ≤ 2.5 μm, PM10 particulate matter with diameter ≤ 10 μm, NOx nitrogen oxides, NO2 nitrogen dioxide
- aDefined by polygenic risk score: low (lowest tertiles), intermediate (second tertiles) and high (highest tertiles)
- bDefined by median of air pollutants including PM2.5, PM10, NO2, and NOx concentration
- cTo estimate RERI and AP, the lower air pollution category and the lowest genetic risk (low PRS) groups were the reference categories
