Table 3 Estimated strength of evidence regarding the effect of endocrine disruptors on health
From: The methodology of quantitative risk assessment studies
Exposure | Outcome | Strength of human evidence | Strength of toxicological evidence | Probability of causation, % |
|---|---|---|---|---|
PBDEs | IQ loss and intellectual disability | Moderate-to-high | Strong | 70–100 |
Organophosphate pesticides | IQ loss and intellectual disability | Moderate-to-high | Strong | 70–100 |
DDE | Childhood obesity | Moderate | Moderate | 40–69 |
DDE | Adult diabetes | Low | Moderate | 20–39 |
Di-2-ethylhexylphthtalate | Adult obesity | Low | Strong | 40–69 |
Di-2-ethylhexylphthtalate | Adult diabetes | Low | Strong | 40–69 |
Bisphenol A | Childhood obesity | Very low-to-low | Strong | 20–69 |
PBDEs | Testicular cancer | Very low-to-low | Weak | 0–19 |
PBDEs | Cryptorchidism | Low | Strong | 40–69 |
Benzyl and butyl-phthalates | Male infertility, resulting in increased assisted reproductive technology | Low | Strong | 40–69 |
Phthalates | Low testosterone, resulting in increased early mortality | Low | Strong | 40–69 |