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Table 2 Associations of metals exposure with diabetic kidney disease in diabetic patients

From: Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients

 

Metals exposure (in blood)

Metals exposure (in urine)

Model 1

Model 2

Model 3

Model 1

Model 2

Model 3

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

Pba

T1

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

T2

1.56 (1.25, 1.94)

1.45 (1.15, 1.82)

1.43 (1.09, 1.86)

1.23 (0.90, 1.70)

1.15 (0.78, 1.67)

1.05 (0.67, 1.63)

T3

2.34 (1.83, 2.97)

1.93 (1.49, 2.51)

1.95 (1.42, 2.67)

1.03 (0.74, 1.43)

0.95 (0.66, 1.36)

0.88 (0.55, 1.42)

P for trend

< 0.001

< 0.001

< 0.001

0.957

0.702

0.657

Per 1 change

1.25 (1.12, 1.40)

1.16 (1.06, 1.28)

1.17 (1.06, 1.29)

0.91 (0.75, 1.11)

0.90 (0.74, 1.09)

0.88 (0.71, 1.11)

Cdb

T1

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

T2

1.48 (1.20, 1.82)

1.24 (0.97, 1.57)

1.32 (1.03, 1.69)

1.21 (0.87, 1.68)

1.03 (0.73, 1.46)

1.07 (0.71, 1.63)

T3

1.70 (1.38, 2.09)

1.47 (1.16, 1.85)

1.68 (1.26, 2.23)

1.40 (0.99, 1.98)

1.23 (0.86, 1.77)

1.44 (0.90, 2.32)

P for trend

< 0.001

0.003

0.002

0.070

0.234

0.147

Per 1 change

1.17 (1.01, 1.34)

1.18 (1.02, 1.37)

1.26 (0.97, 1.65)

1.34 (1.03, 1.74)

1.30 (1.01, 1.68)

1.52 (1.06, 2.02)

  1. Model 1: unadjusted
  2. Model 2: adjusted for age, sex, race/ethnicity, education, PIR, BMI
  3. Model 3: Model 2 + PA, smoking status, alcohol consumption, fish eaten, hypertension. Lead and cadmium were mutually adjusted
  4. Abbreviations: OR, odds ratio; CI, confidence interval; Pb, lead; Cd, Cadmium; PIR, poverty-income ratio; BMI, body mass index; PA, physical activity
  5. aPb, BPb, ug/dL, UPb, ug/L; b Cd, BCd, ug/L, UCd, ug/L
  6. Bold text indicates statistical significance