Table 2 Association between each maternal serum AP concentration (ng/mL; tertile) and child’s intelligence quotient (n = 221)

Total

 NP (cont)

-1.78 (-3.95,0.39)

-1.80 (-4.25,0.64)

-2.13 (-4.85,0.59)

0.03 (-3.14,3.21)

-1.08 (-4.40,2.25)

-2.38(-4.59,-0.16)^*

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-1.27 (-4.86,2.32)

1.52 (-2.51,5.55)

2.00 (-2.48,6.48)

4.14 (-0.05,8.32)^#

-0.52 (-5.00,3.96)

0.14 (-3.54,3.82)

  Tertile 3

-0.67 (-4.31,2.98)

-0.58 (-4.67,3.51)

-0.36 (-4.91,4.19)

-1.07 (-5.53,3.4)

-1.14 (-5.92,3.64)

-1.12 (-4.85,2.61)

  P for trend

0.748

0.727

0.817

0.709

0.638

0.533

 4-N-NP(cont)

0.91 (-5.85,7.66)

-2.93 (-10.52,4.65)

2.14 (-6.32,10.59)

4.67 (-4.26,13.60)

4.05 (-5.34,13.43)

0.87 (-6.05,7.80)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-2.34 (-5.89,1.20)

-1.91 (-5.91,2.09)

-1.93 (-6.39,2.53)

0.03 (-4.24,4.31)

0.83 (-3.74,5.40)

-2.87 (-6.49,0.75)

  Tertile 3

0.70 (-2.49,3.89)

-0.29 (-3.89,3.31)

0.12 (-3.89,4.13)

4.95 (1.14,8.77)^*

2.65 (-1.43,6.73)

1.02 (-2.24,4.27)

  P for trend

0.708

0.850

0.980

0.014

0.204

0.588

 4-T-OP (cont)

-0.12 (-1.59,1.34)

1.10 (-0.54,2.74)

-0.37 (-2.21,1.46)

-0.13 (-1.93,1.67)

-0.26 (-2.15,1.62)

-0.12 (-1.63,1.38)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-0.83 (-4.35,2.68)

-2.38 (-6.30,1.53)

-5.24(-9.58,-0.89)^*

-1.06 (-5.41,3.29)

3.45 (-1.09,7.99)

-1.22 (-4.82,2.38)

  Tertile 3

1.23 (-2.35,4.81)

2.04 (-1.94,6.03)

-0.97 (-5.40,3.45)

0.21 (-4.36,4.78)

2.06 (-2.70,6.83)

1.09 (-2.57,4.76)

  P for trend

0.479

0.285

0.732

0.933

0.388

0.531

 4-N-OP(cont)

2.06 (-3.78,7.89)

4.61 (-1.92,11.14)

-1.05 (-8.36,6.26)

4.49 (-2.03,11.00)

1.39 (-5.49,8.26)

3.33 (-2.63,9.30)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-0.14 (-3.57,3.28)

0.64 (-3.22,4.50)

-0.81 (-5.11,3.48)

2.44 (-1.86,6.73)

2.61 (-1.90,7.13)

-0.79 (-4.30,2.72)

  Tertile 3

0.93 (-2.38,4.23)

0.45 (-3.27,4.17)

-1.32 (-5.46,2.82)

2.76 (-1.34,6.86)

-0.44 (-4.75,3.87)

0.28 (-3.11,3.67)

  P for trend

0.587

0.805

0.528

0.172

0.911

0.882

Boys

 NP (cont)

-1.64 (-4.84,1.56)

-0.95 (-4.31,2.41)

-1.57 (-5.39,2.26)

-1.40 (-5.65,2.85)

-1.19 (-5.33,2.96)

-1.81 (-5.08,1.47)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-0.36 (-5.68,4.97)

2.48 (-3.06,8.03)

1.39 (-4.96,7.73)

5.54 (-0.47,11.54)^#

0.82 (-5.24,6.89)

0.17 (-5.28,5.62)

  Tertile 3

-0.08 (-5.58,5.42)

-0.33 (-6.05,5.40)

-0.62 (-7.18,5.93)

-3.38 (-9.91,3.15)

-3.47 (-10.07,3.13)

-1.20 (-6.82,4.43)

  P for trend

0.990

0.800

0.789

0.452

0.338

0.641

 4-N-NP(cont)

3.41 (-5.77,12.60)

-5.00 (-14.59,4.60)

-1.39 (-12.38,9.59)

2.56 (-11.25,16.38)

11.50(-1.72,24.72)^#

0.53 (-8.89,9.96)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-3.21 (-8.68,2.27)

-4.04 (-9.81,1.73)

-4.41 (-11.00,2.17)

-4.60 (-11.19,1.98)

-1.09 (-7.59,5.41)

-4.59 (-10.16,0.98)

  Tertile 3

1.86 (-2.53,6.25)

-1.95 (-6.58,2.68)

-0.65 (-5.93,4.63)

3.32 (-2.01,8.66)

3.95 (-1.32,9.22)

1.67 (-2.80,6.13)

  P for trend

0.386

0.421

0.831

0.271

0.154

0.440

 4-T-OP (cont)

0.49 (-1.63,2.61)

1.53 (-0.67,3.74)

-0.20 (-2.73,2.33)

-0.19 (-2.97,2.58)

-0.65 (-3.36,2.05)

0.29 (-1.88,2.46)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-0.16 (-5.25,4.93)

-1.54 (-6.87,3.80)

-5.07 (-11.12,0.98)

-2.37 (-9.04,4.30)

3.35 (-3.08,9.79)

0.22 (-4.95,5.40)

  Tertile 3

2.96 (-2.20,8.11)

1.85 (-3.56,7.25)

-1.69 (-7.82,4.44)

-1.05 (-8.24,6.14)

-0.54 (-7.48,6.41)

-0.54 (-5.33,4.24)

  P for trend

0.249

0.484

0.615

0.783

0.855

0.602

 4-N-OP(cont)

2.28 (-6.79,11.36)

2.78 (-6.72,12.29)

-2.36 (-13.2,8.47)

-0.18(-10.58,10.23)

7.64 (-2.35,17.62)

4.38 (-4.89,13.65)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

1.77 (-3.27,6.81)

1.20 (-4.07,6.48)

-1.00 (-6.99,4.98)

-1.20 (-7.66,5.26)

2.72 (-3.54,8.98)

-0.84 (-6.08,4.40)

  Tertile 3

0.42 (-4.25,5.09)

-1.13 (-6.01,3.75)

-3.71 (-9.24,1.83)

0.32 (-5.60,6.25)

-0.55 (-6.29,5.19)

1.35 (-3.95,6.66)

  P for trend

0.862

0.643

0.185

0.937

0.904

0.821

Girls

 NP (cont)

-1.79 (-4.98,1.41)

-1.75 (-5.63,2.13)

-2.96 (-6.49,0.56)

3.57 (-1.65,8.79)

-1.43 (-7.51,4.65)

-2.62 (-5.79,0.56)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-2.36 (-7.62,2.91)

2.40 (-3.99,8.79)

1.86 (-4.00,7.72)

4.97 (-1.28,11.23)

-2.63 (-9.95,4.69)

0.69 (-4.61,5.99)

  Tertile 3

-1.39 (-6.76,3.98)

1.19 (-5.33,7.71)

-1.27 (-7.23,4.70)

1.32 (-5.44,8.08)

-0.96 (-8.87,6.96)

-0.86 (-6.26,4.55)

  P for trend

0.612

0.720

0.664

0.692

0.805

0.749

 4-N-NP(cont)

-4.28 (-15.69,7.14)

1.36(-12.53,15.24)

13.48(1.09,25.87)^*

7.18 (-5.67,20.04)

-0.03 (-14.96,14.91)

1.51 (-9.98,13.00)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-1.44 (-6.40,3.52)

-0.99 (-6.99,5.01)

1.57 (-3.92,7.05)

4.57 (-1.38,10.53)

3.06 (-4.05,10.16)

-1.14 (-6.12,3.84)

  Tertile 3

-1.16 (-6.20,3.88)

1.74 (-4.36,7.84)

2.59 (-3.04,8.21)

6.66 (0.96,12.36)^*

1.87 (-4.93,8.68)

-0.17 (-5.23,4.90)

  P for trend

0.613

0.622

0.350

0.020

0.557

0.905

 4-T-OP (cont)

-0.80 (-2.96,1.37)

1.09 (-1.53,3.72)

-0.75 (-3.15,1.66)

0.31 (-2.28,2.89)

0.12 (-2.85,3.10)

-0.6 (-2.77,1.58)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-1.41 (-6.49,3.68)

-3.27 (-9.26,2.73)

-4.40 (-10.08,1.28)

-0.08 (-6.25,6.09)

2.67 (-4.40,9.74)

-1.46 (-6.56,3.64)

  Tertile 3

-1.33 (-6.81,4.14)

3.71 (-2.73,10.16)

-1.35 (-7.34,4.64)

2.24 (-4.36,8.84)

3.75 (-3.82,11.32)

0.38 (-5.10,5.87)

  P for trend

0.627

0.267

0.657

0.520

0.311

0.892

 4-N-OP(cont)

3.30 (-4.97,11.57)

9.39(-0.46,19.25)^#

1.08 (-8.13,10.29)

10.30(1.18,19.43)^*

-3.14 (-14.01,7.73)

4.08 (-4.20,12.37)

  Tertile 1

Ref

Ref

Ref

Ref

Ref

Ref

  Tertile 2

-2.04 (-7.07,2.98)

0.53 (-5.60,6.66)

-0.97 (-6.61,4.67)

6.78 (0.57,12.98)^*

2.35 (-5.11,9.81)

-1.68 (-6.74,3.38)

  Tertile 3

2.16 (-2.89,7.20)

3.68 (-2.47,9.83)

2.01 (-3.65,7.67)

6.33 (0.17,12.49)^*

-0.06 (-7.46,7.35)

2.09 (-2.99,7.16)

  P for trend

0.457

0.248

0.513

0.033

0.956

0.467