Table 4 HR (95% CIs) of the progression of liver fibrosis according to tertiles of plasma chlordecone, DDE, and PCB-153 concentrations
POPs | F0 N (%) | F4 N (%) | Crude HR (95% CI) | Adjusted HR (95% CI)* | Adjusted HR (95% CI)** | |||
|---|---|---|---|---|---|---|---|---|
Chlordecone (µg/L) | ||||||||
≤ 0.07 | 7 (15.6) | 44 (39.6) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | |||
> 0.07-<0.45 | 21 (46.7) | 31 (27.9) | 0.57 (0.33–0.97) | 0.04 | 0.58 (0.34–1.02) | 0.06 | 0.57 (0.33–1.00) | 0.05 |
≥ 0.45 | 17 (37.8) | 36 (32.4) | 0.49 (0.30–0.81) | 0.005 | 0.56 (0.34–0.95) | 0.03 | 0.58 (0.35–0.99) | 0.05 |
p Trend | 0.008 | 0.04 | 0.05 | |||||
DDE (µg/L) | ||||||||
≤ 0.64 | 21 (46.7) | 32 (28.8) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | |||
> 0.64-<1.62 | 13 (28.9) | 39 (35.1) | 1.00 (0.59–1.72) | 0.98 | 1.27 (0.73–2.24) | 0.39 | 1.22 (0.69–2.18) | 0.49 |
≥ 1.62 | 11 (24.4) | 40 (36.0) | 0.76 (0.43–1.35) | 0.35 | 1.05 (0.56–1.95) | 0.88 | 1.05 (0.55–1.99) | 0.89 |
p Trend | 0.10 | 0.66 | 0.83 | |||||
PCB-153 (µg/L) | ||||||||
≤ 0.31 | 19 (42.2) | 36 (32.4) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | |||
> 0.31-<0.71 | 14 (31.1) | 35 (31.5) | 0.57 (0.33–0.97) | 0.04 | 0.78 (0.45–1.35) | 0.38 | 0.73 (0.42–1.29) | 0.28 |
≥ 0.71 | 12 (26.7) | 40 (36.0) | 0.43 (0.25–0.74) | 0.003 | 0.78 (0.44–1.38) | 0.39 | 0.68 (0.35–1.32) | 0.25 |
p Trend | 0.02 | 0.55 | 0.41 | |||||