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Table 4 Associations between lipid-corrected serum concentrations of organochlorine pesticides and risk of classical papillary thyroid cancer, stratified by sex

From: Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study

OCP levels (ng/g lipid)

Males: 325 case/control pairs

Females: 275 case/control pairs

p-interaction

N cases

N controls

OR

95% CI

N cases

N controls

OR

95% CI

p,p’-DDE

 <LOD-78.56

66

73

1.00

Ref.

71

79

1.00

Ref.

 

 78.57-129.69

82

80

1.01

(0.62–1.67)

60

70

1.01

(0.59–1.73)

 

 129.70-233.49

97

90

1.03

(0.63–1.71)

75

58

1.52

(0.88–2.63)

 

 233.50-2,049.00

80

82

0.84

(0.47–1.49)

69

68

1.27

(0.67–2.39)

 

 p-trend

   

0.55

   

0.59

0.76

p,p’-DDT

 <LOD

178

192

1.00

Ref.

158

174

1.00

Ref.

 

 ≥LOD-6.30

47

47

0.96

(0.60–1.53)

22

29

0.91

(0.49–1.71)

 

 6.31–10.35

51

43

1.05

(0.61–1.80)

53

37

1.70

(0.97–2.98)

 

 10.36–126.80

47

40

1.18

(0.68–2.05)

37

30

1.50

(0.80–2.84)

 

 p-trend

   

0.61

   

0.51

0.78

HCB

 <LOD

148

158

1.00

Ref.

135

157

1.00

Ref.

 

 ≥LOD-6.36

66

64

1.01

(0.64–1.60)

39

31

1.57

(0.92–2.68)

 

 6.37–8.64

47

43

1.05

(0.63–1.74)

33

42

1.01

(0.56–1.83)

 

 8.65–150.70

59

49

1.22

(0.72–2.08)

60

37

2.23

(1.23–4.06)

 

 p-trend

   

0.56

   

0.02

0.30

Oxychlordane

 <LOD

130

158

1.00

Ref.

139

152

1.00

Ref.

 

 ≥LOD-7.95

63

60

1.21

(0.76–1.91)

40

37

1.22

(0.71–2.10)

 

 7.96–12.65

67

51

1.43

(0.88–2.32)

48

46

1.24

(0.70–2.18)

 

 12.66–104.80

64

55

1.21

(0.71–2.04)

47

37

1.47

(0.81–2.68)

 

 p-trend

   

0.28

   

0.27

0.86

trans-Nonachlor

 <LOD

81

105

1.00

Ref.

102

104

1.00

Ref.

 

 ≥LOD-8.92

61

76

0.92

(0.58–1.47)

54

56

0.99

(0.61–1.63)

 

 8.93–15.84

85

66

1.66

(1.02–2.70)

56

65

0.92

(0.56–1.57)

 

 15.85–304.30

98

78

1.56

(0.93–2.60)

61

50

1.22

(0.70–2.29)

 

 p-trend

   

0.07

   

0.56

0.26

β-HCCH

 <LOD

246

250

1.00

Ref.

202

227

1.00

Ref.

 

 ≥LOD (2.77–153.80)

74

68

0.88

(0.57–1.35)

68

47

1.76

(1.07–2.89)

0.10

Mirex

 <LOD

266

265

1.00

Ref.

239

237

1.00

Ref.

 

 ≥LOD (2.88–348.20)

57

57

1.03

(0.65–1.63)

31

33

0.90

(0.50–1.62)

0.73

  1. All models adjusted for BMI (< 25 kg/m2, 25–29.9 kg/m2, ≥ 30 kg/m2, missing) and military branch (Army, Air Force, Navy, Marines/Coast Guard)
  2. Bolding denotes statistical significance
  3. Abbreviations: CI Confidence interval, DDE Dichlorodiphenyldichloroethylene, DDT Dichlorodiphenyltrichloroethane, HCB Hexachlorobenzene, HCCH Hexachlorocyclohexane, LOD Limit of detection, OR Odds ratio