Table 4 Multivariable logistic regression analysis of factors associated with severe COVID-19

CGMH linkou branch

1.414 (0.865–2.309)

0.167

Age (with each year increase)

1.088 (1.072–1.103)

 < 0.001

Male

2.587 (1.838–3.641)

 < 0.001

Body mass index

0.947 (0.914–0.980)

0.002

Smoking (current)

1.426 (0.805–2.523)

0.223

Smoking (former)

0.653 (0.396–1.077)

0.095

 ≥ One comorbidity

7.359 (4.668–11.601)

 < 0.001

WBC

1.219 (1.158–1.283)

 < 0.001

Neutrophil

1.064 (1.049–1.078)

 < 0.001

Lymphocyte

0.857 (0.836–0.878)

 < 0.001

0.860 (0.787–0.940)

0.001

0.888 (0.838–0.942)

 < 0.001

Neutrophil/lymphocyte ratio

1.272 (1.208–1.338)

 < 0.001

Hemoglobin

0.695 (0.639–0.757)

 < 0.001

Platelets

0.994 (0.992–0.996)

 < 0.001

0.984 (0.973–0.995)

0.005

0.986 (0.977–0.995)

0.004

Serum creatinine

2.835 (2.033–3.955)

 < 0.001

Ferritin

1.003 (1.002–1.004)

1.003

LDH

1.017 (1.013–1.020)

 < 0.001

1.010(1.001–1.020)

0.035

1.014 (1.004–1.024)

0.005

CRP

1.107 (1.080–1.134

 < 0.001

1.045 (1.013–1.077)

0.005

1.060 (1.031–1.090)

 < 0.001

IL-6

1.184 (1.126–1.246)

 < 0.001

Blood cadmium

3.220 (2.075–4.996)

 < 0.001

Blood nickel

1.575 (0.588–4.222)

0.367

Urine cadmium/creatinine

3.780 (2.950–4.844)

 < 0.001

1.643 (1.060–2.547)

0.026

Urine nickel

1.091 (1.023–1.164)

0.008

Urine cadmium/creatinine > 2.05 μg/g

5.349 (1.118–25.580)

0.036