Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Table 4 Mean adjusted associations from WQS logistic regression model with 100 repeated holdouts between per- and polyfluoroalkyl substance (PFAS) mixture and odds of rheumatoid arthritis (RA)

Notes All chemicals were log₂ transformed to reduce skewness in the distribution of the concentrations
Abbreviations WQS, weighted quantile sum; SD, standard deviation; CI, confidence interval; OR, odds ratio
^aThe associations are derived from a stratified WQS logistic regression model allowing for sex-specific weights and including an interaction term WQS*sex. The model was run with 100 repeated holdouts using 40% of the data as training and 60% as validation set. The models were adjusted for age, sex, ethnicity, educational attainment, BMI, poverty income ratio, alcohol consumption, and physical activity
^bThe mean OR over the 100 repeated holdouts is presented with its 95% confidence interval
^cThe number of adjusted ORs from the 100 repeated holdouts that were below 1

ISSN: 1476-069X