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A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Bangladesh
© George et al.; licensee BioMed Central Ltd. 2012
Received: 10 December 2011
Accepted: 31 May 2012
Published: 19 June 2012
To reduce arsenic (As) exposure, we evaluated the effectiveness of training community members to perform water arsenic (WAs) testing and provide As education compared to sending representatives from outside communities to conduct these tasks.
We conducted a cluster based randomized controlled trial of 20 villages in Singair, Bangladesh. Fifty eligible respondents were randomly selected in each village. In 10 villages, a community member provided As education and WAs testing. In a second set of 10 villages an outside representative performed these tasks.
Overall, 53% of respondents using As contaminated wells, relative to the Bangladesh As standard of 50 μg/L, at baseline switched after receiving the intervention. Further, when there was less than 60% arsenic contaminated wells in a village, the classification used by the Bangladeshi and UNICEF, 74% of study households in the community tester villages, and 72% of households in the outside tester villages reported switching to an As safe drinking water source . Switching was more common in the outside-tester (63%) versus community-tester villages (44%). However, after adjusting for the availability of arsenic safe drinking water sources, well switching did not differ significantly by type of As tester (Odds ratio =0.86[95% confidence interval 0.42-1.77). At follow-up, among those using As contaminated wells who switched to safe wells, average urinary As concentrations significantly decreased.
The overall intervention was effective in reducing As exposure provided there were As-safe drinking water sources available. However, there was not a significant difference observed in the ability of the community and outside testers to encourage study households to use As-safe water sources. The findings of this study suggest that As education and WAs testing programs provided by As testers, irrespective of their residence, could be used as an effective, low cost approach to reduce As exposure in many As-affected areas of Bangladesh.
KeywordsArsenic Health educational intervention Bangladesh
Exposure to elevated levels of inorganic arsenic (As) is associated with cancers of the skin, bladder, and lung [1–3], developmental effects [4, 5], cardiovascular disease [6, 7], and skin lesions [8, 9]. Chronic As exposure is also associated with deficits in childhood cognitive and motor function [5, 10, 11]. Recent data suggest associations between chronic As exposure from drinking water and mortality .
Groundwater pumped from approximately half the estimated 10 million tubewells in Bangladesh do not meet the World Health Organization (WHO) guideline for As of 10 μg/L . In 2006, Ahmed et al reported that 57% of the estimated population of 28–35 million initially exposed to As above the Bangladesh standard of 50 μg/L remain exposed. The most commonly used As mitigation option is well switching (67%), followed by the use of deep tubewells (28%) . Mitigation options such as piped water systems, rainwater collection, dugwells, As filters, and pond sand filters are utilized by a very small proportion of the population [13, 14].
Even when provided with As education, households do not always seek As-safe drinking water sources [15–18]. Testing programs typically involve a representative from an outside organization coming into a village to test the well water for As. These staff label the spout of each well red if the As concentration is greater than 50 μg/L (As–contaminated well) and green if the As concentration in the well is less than 50 μg/L (As-safe well). After the results of the As test are provided, the representative typically leaves the village without providing the resources or in-depth knowledge to address health concerns or mitigation options . The lack of resources at the local level, we hypothesize, may be an important factor limiting the impact of As testing programs. Previous interventions have found that the provision of As education and water arsenic (WAs) testing can encourage households with As contaminated wells to switch to alternative drinking water sources [14, 19–21]. However, no studies to date evaluated the effectiveness of having a community member, rather than an outside representative, provide these services.
In 2010, we developed an As education and WAs testing intervention for rural villages in Singair, Bangladesh. Our study objective was to evaluate the effectiveness of having community members, compared to outside representatives, conduct WAs testing and As education. The primary study outcome was switching to an As safe well among those with As contaminated wells at baseline; the secondary outcome was the change in urinary As (UAs) concentration. We hypothesized that the community tester would be more effective since they could provide additional reinforcement by living in the village. Community involvement in As testing may provide a sustainable and less costly option for communities to monitor their As exposure and may represent a model for government or non-governmental agencies to conduct future interventions.
This study was conducted in rural villages in Singair Upazila, located in the Manikganj district of Bangladesh. This study area was selected due to its wide range of WAs concentrations, and the presence of the Christian Commission for Development Bangladesh (CCDB), a non-governmental organization that assisted with the implementation of this intervention.
Eligibility and Enrollment
We first administered a household drinking water survey to the person responsible for primary drinking water collection in 6746 households in 26 villages . Information was collected about: As status of the household’s primary drinking water source (safe, contaminated, untested), well depth, and well installation date.
This study was a cluster based, randomized controlled trial of 1000 households. Randomization was performed at the village level; participants were clustered within each village. Fifty eligible households were randomly selected based on the household drinking water survey. Each respondent was interviewed at baseline and at follow-up 7–9 months later (Figure 1). In ten villages, a trained community member conducted well WAs testing and provided As education. In the remaining 10 villages, an outside representative, defined as someone living in a different union, performed these tasks. The two groups of villages were geographically separated. Using census data from the Bangladesh Bureau of Statistics, villages were matched on literacy rate and land ownership as these are strong indicators of socioeconomic status . We also attempted to match villages on the proportion of As contaminated wells based on our household drinking water survey. Villages were randomly assigned by the study coordinator to each intervention group at baseline using the random number generator in SAS, version 9.2 (SAS Institute Inc., Cary, NC, USA). Study households in each village were randomly selected in the same manner.
The 10 “community-testers” were forum workers for CCDB who organize community activities on health and poverty alleviation. All As testers were required to be at least 18 years of age and literate. The distribution of age, educational level, gender, and religion did not differ significantly between the community and outside testers.
All testers received a one week intensive training on how to measure the As content of wells and effectively disseminate As education. The tester went to each study household at least once to: 1) measure the As concentration of the household’s primary drinking water source using an As field testing kit; 2) conduct a structured 40 minute As education session; and 3) provide assistance to participants with As contaminated wells to locate a nearby As-safe drinking water source. These tasks were performed in each study village over a period of 3 months.
The As education materials were developed based on ther current scientific literature regarding the health implications of As exposure, studies assessing the knowledge of As in the population [16, 17, 24, 25], and our As education pilot study. Education sessions focused on key messages regarding the health implications of chronic As exposure, and methods to reduce exposure. The sessions were designed to be interactive by asking participants questions about the topics being covered. If a participant’s primary drinking water source was found to be As contaminated, assistance to locate a nearby As-safe drinking water source was provided. In such cases, participants were asked from which water source they would like to collect their drinking and cooking water. If this water source was found to be As-safe and the well owner agreed, the As tester encouraged the participant to collect all of their drinking and cooking water from this source.
During the baseline and follow-up surveying periods, interviewers visited each study household to: 1) administer a questionnaire to the person responsible for primary drinking water collection; 2) collect a sample of the primary drinking water source; and 3) collect a urine sample from the study respondent.
Both questionnaires obtained information on water usage, socio-demographics characteristics, and knowledge of As. The participant’s knowledge of As was obtained via a 20 item quiz administered at the baseline survey before the start of the intervention and at the follow-up survey. Participants were queried on how to identify As contaminated wells, safe uses of As contaminated water, and the health implications of chronic As exposure. One point was given for a correct item, and zero points for an incorrect item. Possible quiz scores ranged between zero and 20.
Urinary As concentrations collected at baseline and follow-up were used as a biological index of As exposure. Previous studies have found strong correlations between urinary As and drinking WAs concentrations [20, 26, 27]. Switching from an As–contaminated to a safe well can reduce urinary Asconcentrations to a level that approaches those of individuals who have been consistently relying on safe wells . Urine samples were collected from study respondents in 50 ml acid washed tubes during the baseline and follow-up periods. Urine samples were placed in portable coolers, then frozen at −20 °C at the local laboratory in Dhaka, Bangladesh, and shipped on dry ice to Columbia University. Total urinary As was measured using a Perkin-Elmer AAnalyst 600 graphite furnace system, and adjusted for urinary creatinine (Cr) concentrations according to published methods . Our laboratory is part of a quality control program for total urinary As which is coordinated by the Institut de Santé Publique du Québec (Québec, Canada). During the course of this study, the intraclass correlation coefficient between our laboratory’s values and samples calibrated at the Quebec laboratory was 0.99. The average intra-precision and inter-precision for three control urine samples run daily for this period were 2.6%, and 5.7%, respectively.
WAs field testing was conducted using the Hach EZ As Test Kit (Part No. 2822800) which measures As concentrations in water using a colorimetric scale that ranges from 0–500 μg/L. A 40 minute reaction period was used in these studies rather than the manufacturer recommended 20 minutes because a previous study showed that the increased reaction period reduced inconsistencies in the 50–100 μg/L range [22, 29].
WAs measurements conducted using the Hach EZ As test Kit were verified by laboratory analysis at the Geochemistry Research Laboratory at the Lamont Doherty Earth Observatory (LDEO) at Columbia University. The As concentrations were measured using Inductively-Coupled Plasma-Mass Spectrometry (ICP-MS) with a detection limit of 0.1 μg/L [30, 31].
The primary hypothesis of this study was that training a community member to perform As testing and provide As education is more effective than sending a trained person from outside the village to conduct these same tasks, conditional on equal competence and similar observed characteristics of the tester.
Based on a previous study conducted in Araihazar, Bangladesh, we assumed that the proportion of well switching would be 0.33 in our outside tester villages and 0.66 in our community-tester villages [14, 21]. Furthermore, based on the results of our household drinking water survey we estimated that approximately 50% (500) of the 1000 respondents included into our study population would be using wells that were As contaminated. We specified the type 1 error, the probability of rejecting Ho when it is true, at 5% and the type 2 error, the probability of not rejecting Ho when it is false, at 20%. Thus, we required 18 villages with 35 households each. To account for at least a 10% loss to follow up, we selected a sample size of 20 villages of 50 households each.
The outcome variables in this study were: 1) questionnaire reported well switching; and 2) change in urinary As concentration. We evaluated the determinants of well switching for study respondents with As–contaminated wells at baseline. Safe and As–contaminated were defined according to the Bangladesh WAs standard of 50 μg/L. Chi-square tests and two sample t-tests were used to compare differences between the community-tester and outside-tester villages for categorical and continuous variables, respectively.
Logistic regression was used to estimate the odds of well switching controlling for both individual and village level covariates. Generalized estimating equations (GEE) were used to account for clustering within villages . We estimated the most parsimonious model by eliminating all non statistically significant variables (p >0.05), except for those a priori specified (ie. Type of As Tester) until the lowest quasi likelihood information criterion (QIC) was determined . All analyses were performed using SAS, version 9.2 (SAS Institute Inc., Cary, NC, USA).
The study protocol was approved by the Columbia University Medical Center Institutional Review Board and the Bangladesh Medical Research Council. Informed consent was obtained from all study respondents.
During our baseline survey, 1033 respondents with untested wells, selected from our household drinking water survey, were screened for eligibility. Of these, 4 (0.4%) were unwilling to participate and 29 (2.8%) were ineligible. At follow-up, 30 (3%) respondents had either permanently moved  or died . Urine was collected from 953 (95%) respondents at baseline and 930 (96%) respondents at follow-up. Five hundred and forty three (56%) respondents were found to be using As contaminated wells, and 427 (44%) were found to be using As safe wells.
Baseline and follow-up characteristics by arsenic tester village
Community tester villages (N = 487)
Outside tester villages (N = 483)
Age (yrs) [ Mean ± SD(Range)]
36.3 ± 11.4 (18–102)
37.8 ± 12.8(18–86)
Respondent can read and write (%)
Head of household education (%)
Respondent baseline knowledge of arsenic quiz score mean ± SD(range)
8.5 ± 3.0(0–18)
Radio ownership (%)
Land ownership (%)
No land ownership
Less than 1 Acre
1 to 2 Acres
Well ownership (%)
Proportion of unsafe wells in respondent's village(%)
Minutes to an arsenic safe drinking water source for unsafe well owners (%) (N = 587)
Less than or equal to 5 minutes
Arsenic status of tubewell
Baseline water arsenic [μg/L(Mean ± SD(range))] 1
124 ± 145 (0–500)
117 ± 147 (0–500)
Baseline creatinine-adjusted urinary As [μg/g Cr (Mean ± SD(range))] 1
178 ± 122.0(9–901)
Predictors of well switching among unsafe well users
% Who switched2
OR for switching (95% CI)3
Outside arsenic tester
Community arsenic tester
Proportion of unsafe wells in respondent's village
Less than 60%
Greater or equal to 60%
Minutes to safe drinking water source
Less than or equal to 5 minutes
Greater than 5 minutes
Predictors of well switching among unsafe well users
% Who switched2
OR for switching (95% CI)3
Follow-up knowledge of arsenic quiz score
Number of times met with arsenic tester
4 or more times
Follow-up characteristics by arsenic tester village
Community tester villages (N = 487)
Outside tester villages (N = 483)
Respondent follow-up arsenic knowledge quiz score
14.3 ± 3.2(4–20)
14.0 ± 3.6(4–20)
Number of times met with arsenic tester(%)
4 or more times
Switching status (%)
Did Not Switch
Reason for switching, amoung those unsafe well users who switched(%) (N = 287)
Previous tubewell was unsafe for arsenic
Previous tubewell broken
Too many people using previous tubewell
Dug a new tubewell
Did not like the taste of previous tubewell
Did not like the color of previous tubewell
None of these
Reason for not switching, amoung those unsafe well users who did not switched(%) (N = 256)
Distance of the safe tubewell was too far
Family owns its own tubewell and doesn't wish to impose on others
Arsenic safe well had too many users
Safe well owner near home does not want to share
Alternative well had bad taste
Alternative well had unusual color
None of these
Follow-up creatinine-adjusted urinary As [μg/g Cr (Mean ± SD(range))]
128 ± 150(24–1905)
Number of arsenic test conducted
Participants who lived in villages with > 60% As contaminated wells, classification used by the Bangladeshi and UNICEF, were significantly less likely to switch in comparison to those who lived in villages with < 60% As–contaminated wells (OR = 0.25; 95% CI (0.13-0.48)). In villages with less than 60% As–contaminated wells, 74% of study households in the community tester villages, and 72% of households in the outside tester villages reported switching to an As safe drinking water source. In contrast to only 35% wells switching in villages with greater than 60% As contaminated wells. In addition, participants who required more than 5 minutes to walk to an As-safe drinking water source were significantly less likely to switch in comparison to those who lived within 5 minutes of an As-safe drinking water source (OR = 0.55; 95% CI [0.32-0.96]). Finally, participants who owned their own well were significantly less likely to switch in comparison to those who did not own their own well (OR = 0.41; 95% CI (0.25-0.65)).
Among participants with As contaminated wells who changed their drinking water source, the most common reported reason for switching was that their baseline well was As–contaminated (92%). The most common reported reasons for not switching wells were: 1) long distance to a safe well (57%); 2) family ownership of well (20%); and 3) owner(s) of safe wells near the respondent’s home do not want to share (11%). Eight percent of respondents with safe wells at baseline switched. The most common reported reason for well switching among these respondents were: 1) did not like the taste of their previous well water (23%); 2) dug a new well (17%); and 3) previous well broke (17%). Similar reasons were given by participants in the two intervention groups.
Millions in Bangladesh continue to drink groundwater containing elevated levels of As . Many households lack access to As testing services, preventing them from knowing the As status of their wells and locating As-safe water sources in their villages. Thus, there is an urgent need for effective As education and WAs testing programs in Bangladesh [13–15]. This study is the first randomized trial evaluating the effectiveness of community participation in As mitigation in Bangladesh. We hypothesized that community-testers would be more effective than outside-testers in terms of reducing As exposure because the former would offer additional reinforcement by living within the community. Although our data did not support this hypothesis, the intervention program was very successful in encouraging households to use As-safe drinking water sources. Fifty-three percent of participants with As contaminated wells at baseline switched wells at follow-up, mostly because their baseline well was As contaminated relative to As.
We observed that the reinforcement provided by the availability of an As tester within the village was positively related to well switching. Through their continued presence, the community-tester provided significantly more reinforcement in the village than the outside-tester as evidenced by the number of contacts between the participants and the testers. The knowledge of As quiz scores were significantly higher for respondents at follow-up, compared to baseline, for both intervention groups (Unpublished).
We observed significant reductions in UAs concentrations for As–contaminated well users who reported switching wells at follow-up, indicating that our intervention was successful in reducing a biomarker of As exposure. Previous studies in Taiwan indicate that a reduction of As exposure may reduce associated mortality from renal diseases [33, 34], intracerebral hemorrhage , and ischemic heart disease . A study in Chile found that reduced As intake was associated with decreased numbers of micro-nucleated cells in the bladder .
Sources of dietary As such as cooking rice in contaminated water or using rice with elevated As concentration can contribute to elevated urinary As concentrations [38, 39]. Therefore it is possible that food As has contributed to the ingested dose of As in our study population. However the literature suggests that when water As concentrations exceed 50 μg/L that ingested water As is the dominant exposure route . In our educational program we encouraged households to both drink and cook with As safe water. Only 8% of study respondents using As contaminated wells at baseline who switched to safe wells at follow-up reported using their previous tubewell for cooking.
Our findings are consistent with an intervention for 11,746 participants conducted in Araihazar, Bangladesh. That intervention, administered over a two-year period, involved WAs testing and labeling, village level As education, and the targeted installation of deep tubewells with low WAs. At follow-up, 58% of As contaminated well users and 17% of safe well users had switched to new drinking water sources. A 46% reduction in UAs was observed for those with As–contaminated wells who switched to As-safe drinking water sources . Our current intervention was conducted over a much shorter duration and did not involve the installation of deep tubewells, yet we observed roughly comparable results.
The unavailability of As-safe drinking water sources, i.e. the proportion of As–contaminated wells, in a village was the greatest barrier to well switching. In villages with less than 60% As contaminated wells, 72% of respondents with As–contaminated wells switched, compared to 35% well switching in villages with greater or equal to 60% As–contaminated wells. This is consistent with Hanchett et al., who found that the unavailability of As-safe water sources was a barrier to well switching in six districts of Bangladesh . In our study, the time to walk to As–safe water source was also a significant barrier to well switching. Previous studies have indicated that well switching significantly declines if the nearest safe well is located more than 100 meters away [14, 20, 21]. Well ownership was also a significant barrier to well switching, likely because well owners are more reluctant to shift from a well in which they invested their own money. All of these barriers to well switching were significantly higher in the community versus outside tester villages suggesting a possible reason for the lower well switching observed in these villages.
Our study suggests that WAs testing and As education programs would be most effective in areas where <60% of wells are As-contaminated. In these villages the vast majority of respondents with contaminated wells switched (72%). A recent report of a nationwide survey in Bangladesh indicated that 77% of the population lives in areas with between 0-60% of their wells being As contamination . Therefore our intervention is a viable option for the majority of the population residing in As affected areas of Bangladesh. For the 23% of the population who reside in areas with > 60% As–contaminated wells, this intervention will likely need to be combined with the provision of alternative mitigation options such as the installation of deep tubewells, As filters, or rain water harvesting.
A major limitation of our study was the relatively short three month duration of our intervention period. We hypothesized that community-testers would be more effective than outside-testers because of their additional reinforcement. While we did observe that the community-testers provided significantly more reinforcement than the outside testers, this did not appear to increase their effectiveness in reducing As exposure. We attribute this result in part to the significantly higher proportion of As–contaminated well located in the community-tester villages and in part to the short duration of the study. Nevertheless, the use of the community-testers provides a potentially sustainable approach for As mitigation because of the continued presence of the testers in villages over time to provide additional reinforcement and WAs testing services. Further, community testers will likely be less costly because they do not require transportation costs. We recommend that if this intervention approach is upscaled that it be incorporated in existing community health worker programs conducted by non-governmental organizations or by local government. This would reduce the required operation cost. Working with existing organizations would also allow for greater accountability of those providing the As testing and education and make refresher trainings over time easier to organize.
In conclusion, the overall intervention was effective in reducing As exposure provided there were As-safe drinking water sources available. However, there was not a significant difference observed in the ability of the community and outside testers to encourage study households to use As-safe water sources. The findings of this study suggest that As education and WAs testing programs provided by As testers, irrespective of their residence, could be used as an effective, low cost, easy to deliver intervention approach to reduce As exposure in many As-affected areas of Bangladesh. Furthermore, this approach has the advantage of not involving costly As filters, deep tubewells, or As treatment plants.
This study was supported by funds from the National Institute of Health grant number NIEHS ES P42 10349 and the Earth Institute at Columbia University. In addition, Christine Marie George was the recipient of an EPA Star Fellowship and a Fulbright Fellowship. We would like to thank the Christian Commission for Development Bangladesh (CCDB) and our arsenic testers for their support of our project: Dr. Afroz Mahal and Almas Hossain. We would also like to thank the staff at the Columbia University Arsenic & Health Research in Bangladesh office and our interviewers from Dhaka University, Department of Geology for their tireless support: Khaled Hasan, Zakir Hossain, Sawkat Haiat Sarwar, Dr. Rakibuz Zaman, Dr. Mahfuzar Rahman, Dr Abu Bakar Siddique, Golam Sarwar, Nur-E-Azam Sarwar, Shariful Islam Khan, Lisma Akhter, Shawkat Jahangir, Shahid Ahmed Sorwar, Nahid Farjana, Tahmina Akter, Jesmin Neher, Murad Hossain, Ershad Bin Ahmed, Iftakharul Alam, Jahid Alam, Masud Al Noor, Majibul Hosain, Anisur Rahaman Khan, Jismin Neher, Jakir Hossain Mir, Kalpana Rani Das, and Abul Kalam Azad.
- Marshall G, Ferreccio C, Yuan Y, Bates MN, Steinmaus C, Selvin S: Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water. J Natl Cancer Inst. 2007, 99 (12): 920-8. 10.1093/jnci/djm004.View ArticleGoogle Scholar
- Chen Y, Ahsan H: Cancer burden from arsenic in drinking water in Bangladesh. Am J Public Health. 2004, 94 (5): 741-4. 10.2105/AJPH.94.5.741.View ArticleGoogle Scholar
- Morales KH, Ryan L, Kuo TL, Wu MM, Chen CJ: Risk of internal cancers from arsenic in drinking water. Environ Health Perspect. 2000, 108 (7): 655-61. 10.1289/ehp.00108655.View ArticleGoogle Scholar
- Calderon J, Navarro ME, Jimenez-Capdeville ME, Santos-Diaz MA, Golden A, Rodriguez-Leyva I: Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ Res. 2001, 85 (2): 69-76. 10.1006/enrs.2000.4106.View ArticleGoogle Scholar
- Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Ahsan H, Levy D: Arsenic and manganese exposure and children's intellectual function. Neurotoxicology. 2011, 32 (4): 450-457. 10.1016/j.neuro.2011.03.009.View ArticleGoogle Scholar
- Chen Y, Factor-Litvak P, Howe GR, Graziano JH, Brandt-Rauf P, Parvez F: Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study. Am J Epidemiol. 2007, 165 (5): 541-52.View ArticleGoogle Scholar
- Chen Y, Graziano JH, Parvez F, Liu M, Slavkovich V, Kalra T: Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. BMJ. 2011, 342: d2431-10.1136/bmj.d2431.View ArticleGoogle Scholar
- Haque R, Mazumder DN, Samanta S, Ghosh N, Kalman D, Smith MM: Arsenic in drinking water and skin lesions: dose–response data from West Bengal, India. Epidemiology. 2003, 14 (2): 174-82.Google Scholar
- Ahsan H, Chen Y, Parvez F, Zablotska L, Argos M, Hussain I: Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am J Epidemiol. 2006, 163 (12): 1138-48. 10.1093/aje/kwj154.View ArticleGoogle Scholar
- Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J: Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ Health Perspect. 2007, 115 (2): 285-9.View ArticleGoogle Scholar
- Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen A: Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect. 2004, 112 (13): 1329-33. 10.1289/ehp.6964.View ArticleGoogle Scholar
- Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Parvez F: Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet. 2010, 376 (9737): 252-8. 10.1016/S0140-6736(10)60481-3.View ArticleGoogle Scholar
- Ahmed MF, Ahuja S, Alauddin M, Hug SJ, Lloyd JR, Pfaff A: Epidemiology. Ensuring safe drinking water in Bangladesh. Science. 2006, 314 (5806): 1687-8.Google Scholar
- Opar A, Pfaff A, Seddique AA, Ahmed KM, Graziano JH, van Geen A: Responses of 6500 households to arsenic mitigation in Araihazar, Bangladesh. Health Place. 2007, 13 (1): 164-72. 10.1016/j.healthplace.2005.11.004.View ArticleGoogle Scholar
- Hanchett S, Nahar Q, Van Agthoven A, Geers C, Rezvi MD: Increasing awareness of arsenic in Bangladesh: lessons from a public education programme. Health Policy Plan. 2002, 17 (4): 393-401. 10.1093/heapol/17.4.393.View ArticleGoogle Scholar
- Paul BK: Arsenic contamination awareness among the rural residents in Bangladesh. Soc Sci Med. 2004, 59 (8): 1741-55. 10.1016/j.socscimed.2004.01.037.View ArticleGoogle Scholar
- Aziz SN, Boyle KJ, Rahman M: Knowledge of arsenic in drinking-water: risks and avoidance in Matlab, Bangladesh. J Health Popul Nutr. 2006, 24 (3): 327-35.Google Scholar
- Caldwell B: Tubewells and Arsenic in Bangladesh: Challenging a Public Health Sucess Story. International Journal of Population Geography. 2003, 9: 23-28. 10.1002/ijpg.271.View ArticleGoogle Scholar
- Hadi A: Fighting arsenic at the grassroots: experience of BRAC's community awareness initiative in Bangladesh. Health Policy Plan. 2003, 18 (1): 93-100. 10.1093/heapol/18.1.93.View ArticleGoogle Scholar
- Chen Y, van Geen A, Graziano JH, Pfaff A, Madajewicz M, Parvez F: Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh. Environ Health Perspect. 2007, 115 (6): 917-23. 10.1289/ehp.9833.View ArticleGoogle Scholar
- Schoenfeld A: Area, Village, and Household Response to Arsenic Testing and Labeling of Tubewells in Araihazar, Bangladesh. 2005, New York City: Columbia UniversityGoogle Scholar
- George CM ZY, Graziano JH, Mey JL, van Geen A: 2011, Environmental Health: Evaluation of the Effectiveness of Building Local Capacity to Conduct Arsenic Testing Services in BangladeshGoogle Scholar
- Ahsan H, Chen Y, Parvez F, Argos M, Hussain AI, Momotaj H: Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation. J Expo Sci Environ Epidemiol. 2006, 16 (2): 191-205. 10.1038/sj.jea.7500449.View ArticleGoogle Scholar
- Caldwell BK, Smith WT, Lokuge K, Ranmuthugala G, Dear K, Milton AH: Access to drinking-water and arsenicosis in Bangladesh. J Health Popul Nutr. 2006, 24 (3): 336-45.Google Scholar
- Parvez F, Chen Y, Argos M, Hussain AZ, Momotaj H, Dhar R: Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study. Environ Health Perspect. 2006, 114 (3): 355-9.View ArticleGoogle Scholar
- Ahamed S, Kumar Sengupta M, Mukherjee A, Amir Hossain M, Das B, Nayak B: Arsenic groundwater contamination and its health effects in the state of Uttar Pradesh (UP) in upper and middle Ganga plain, India: a severe danger. Sci Total Environ. 2006, 370 (2–3): 310-22.View ArticleGoogle Scholar
- Farmer JG, Johnson LR: Assessment of occupational exposure to inorganic arsenic based on urinary concentrations and speciation of arsenic. Br J Ind Med. 1990, 47 (5): 342-8.Google Scholar
- Nixon DE, Mussmann GV, Eckdahl SJ, Moyer TP: Total arsenic in urine: palladium-persulfate vs nickel as a matrix modifier for graphite furnace atomic absorption spectrophotometry. Clin Chem. 1991, 37 (9): 1575-9.Google Scholar
- Van Geen A, Cheng Z, Seddique AA, Hoque MA, Gelman A, Graziano JH: Reliability of a commercial kit to test groundwater for arsenic in Bangladesh. Environ Sci Technol. 2005, 39 (1): 299-303. 10.1021/es0491073.View ArticleGoogle Scholar
- Cheng Z, Zheng Y, Mortlock R, Van Geen A: Rapid multi-element analysis of groundwater by high-resolution inductively coupled plasma mass spectrometry. Anal Bioanal Chem. 2004, 379 (3): 512-8. 10.1007/s00216-004-2618-x.View ArticleGoogle Scholar
- Van Geen A, Ahsan H, Horneman AH, Dhar RK, Zheng Y, Hussain I: Promotion of well-switching to mitigate the current arsenic crisis in Bangladesh. Bull World Health Organ. 2002, 80 (9): 732-7.Google Scholar
- Pan W: Akaike's information criterion in generalized estimating equations. Biometrics. 2001, 57 (1): 120-5. 10.1111/j.0006-341X.2001.00120.x.View ArticleGoogle Scholar
- Yang CY, Chiu HF, Wu TN, Chuang HY, Ho SC: Reduction in kidney cancer mortality following installation of a tap water supply system in an arsenic-endemic area of Taiwan. Arch Environ Health. 2004, 59 (9): 484-8. 10.1080/00039890409603430.View ArticleGoogle Scholar
- Chiu HF, Yang CY: Decreasing trend in renal disease mortality after cessation from arsenic exposure in a previous arseniasis-endemic area in southwestern Taiwan. J Toxicol Environ Health A. 2005, 68 (5): 319-27. 10.1080/15287390590900804.View ArticleGoogle Scholar
- Chiu HF, Lin MC, Yang CY: Primary intracerebral hemorrhage mortality reduction after installation of a tap-water supply system in an arseniasis-endemic area in southwestern Taiwan. J Toxicol Environ Health A. 2007, 70 (6): 539-46. 10.1080/15287390600870940.View ArticleGoogle Scholar
- Chang CC, Ho SC, Tsai SS, Yang CY: Ischemic heart disease mortality reduction in an arseniasis-endemic area in southwestern Taiwan after a switch in the tap-water supply system. J Toxicol Environ Health A. 2004, 67 (17): 1353-61. 10.1080/15287390490471451.View ArticleGoogle Scholar
- Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT: Decrease in bladder cell micronucleus prevalence after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomarkers Prev. 1997, 6 (12): 1051-6.Google Scholar
- Cascio C, Raab A: Jenkins RO, Feldmann J, Meharg AA. Haris PI. The impact of a rice based diet on urinary arsenic. J. Environ. Monit. 2011, 13 (2): 257-265.Google Scholar
- Kile ML, Houseman EA, Breton CV, Smith T, Quamruzzaman Q, Rahman M: Dietary arsenic exposure in Bangladesh. Environmental Health Perspectives. 2007, 115 (6): 889-10.1289/ehp.9462.View ArticleGoogle Scholar
- Situation Analysis of Arsenic Mitigation. 2010, Japan International Cooperation Agency June: Department of Public Health Engineering BangladeshGoogle Scholar
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