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Opportunities and challenges of nanotechnology in the green economy

  • Ivo Iavicoli1Email author,
  • Veruscka Leso1,
  • Walter Ricciardi1,
  • Laura L Hodson2 and
  • Mark D Hoover3
Environmental Health201413:78

https://doi.org/10.1186/1476-069X-13-78

Received: 17 June 2014

Accepted: 29 September 2014

Published: 7 October 2014

Abstract

In a world of finite resources and ecosystem capacity, the prevailing model of economic growth, founded on ever-increasing consumption of resources and emission pollutants, cannot be sustained any longer. In this context, the “green economy” concept has offered the opportunity to change the way that society manages the interaction of the environmental and economic domains. To enable society to build and sustain a green economy, the associated concept of “green nanotechnology” aims to exploit nano-innovations in materials science and engineering to generate products and processes that are energy efficient as well as economically and environmentally sustainable. These applications are expected to impact a large range of economic sectors, such as energy production and storage, clean up-technologies, as well as construction and related infrastructure industries. These solutions may offer the opportunities to reduce pressure on raw materials trading on renewable energy, to improve power delivery systems to be more reliable, efficient and safe as well as to use unconventional water sources or nano-enabled construction products therefore providing better ecosystem and livelihood conditions.

However, the benefits of incorporating nanomaterials in green products and processes may bring challenges with them for environmental, health and safety risks, ethical and social issues, as well as uncertainty concerning market and consumer acceptance. Therefore, our aim is to examine the relationships among guiding principles for a green economy and opportunities for introducing nano-applications in this field as well as to critically analyze their practical challenges, especially related to the impact that they may have on the health and safety of workers involved in this innovative sector. These are principally due to the not fully known nanomaterial hazardous properties, as well as to the difficulties in characterizing exposure and defining emerging risks for the workforce. Interestingly, this review proposes action strategies for the assessment, management and communication of risks aimed to precautionary adopt preventive measures including formation and training of employees, collective and personal protective equipment, health surveillance programs to protect the health and safety of nano-workers. It finally underlines the importance that occupational health considerations will have on achieving an effectively sustainable development of nanotechnology.

Keywords

Green economyNanotechnologySustainable developmentOccupational healthSafetyEnvironmental riskEcologyEngineered nanomaterialsMaterial science

Background

The “green economy” concept has been driven into the mainstream of policy debate by global economic crisis, expected increase in global demand for energy by more than one third between 2010 to 2035, rising commodity prices as well as the urgent need for addressing global challenges in domains such as energy, environment and health [13].

The term “green economy”, chiefly relating to the principles of sustainable development, was first coined in a pioneering 1989 report for the Government of the United Kingdom by a group of leading environmental economists [1]. The most widely used and reliable definition of “green economy” comes from the United Nations Environment Programme which states that “a green economy is one that results in improved human well-being and social equity, while significantly reducing environmental risks and ecological scarcities. It is low carbon, resource efficient, and socially inclusive” [4].

The green economy can also be viewed as a set of principles, aims and actions, which generally include: (i) equity and fairness, both within and between generations, (ii) consistency with the principles of sustainable development, (iii) a precautionary approach to social and environmental impact, (iv) an appreciation of natural and social capital, through, for example, the internalisation of external costs, green accounting, whole-life costing and improved governance, (v) sustainable and efficient resource use, consumption and production, and (vi) a need to fit with existing macroeconomic goals, through the creation of green jobs, poverty eradication, increased competitiveness and growth in key sectors [37].

The green economy concept can indeed play a very useful role in changing the way that society manages the interaction of the environmental and economic domains. In this context, nanotechnology, which is the manipulation of matter in the dimension of 1 to 100 nm, offers the opportunity to produce new structures, materials and devices with unique physico-chemical properties (i.e. small size, large surface area to mass ratio) to be employed in energy efficient as well as economically and environmentally sustainable green innovations [812].

Although expected to exert a great impact on a large range of industrial and economic sectors, the sustainability of green nano-solutions is currently not completely clear, and it should be carefully faced. In fact, the benefits of incorporating nanomaterials (NMs) in processes and products that contribute to outcomes of sustainability, might bring with them environmental, health and safety risks, ethical and social issues, market and consumer acceptance uncertainty as well as a strong competition with traditional technologies [13].

The present review examines opportunities and practical challenges that nano-applications pose in addressing the guiding principles for a green economy. Examples are provided of the potential for nano-applications to address social and environmental challenges, particularly in energy production and storage thus reducing pressure on raw materials, clean-up technologies as well as in fostering sustainable manufactured products. Moreover, the review aims to critically assess the impact that green nanotechnology may have on the health and safety of workers involved in this innovative sector and proposes action strategies for the management of emerging occupational risks.

The potential nanotechnology impact on green innovations

Green nanotechnology is expected to play a fundamental role in bringing a key functionality across the whole value chain of a product, both through the beneficial properties of NMs included as a small percentage in a final device, as well as through nano-enabled processes and applications without final products containing any NMs [13, 14]. However, most of the potential green nano-solutions are still in the lab/start-up phase and very few products have reached the market to date. Further studies are necessary to assess the applicability, efficiency and sustainability of nanotechnologies under more realistic conditions, as well as to validate NM enabled systems in comparison to existing technologies. The following paragraphs will describe the potential fields of application for green nanotechnology innovations.

Nanomaterials for energy conversion

One of the most interesting and most flexible renewable energy technologies is the direct conversion of sunlight into electric power: the photovoltaic effect [8, 15]. Carbon NMs, including C60 fullerenes [16, 17], carbon nanotubes (CNTs) [18, 19] and graphene [20, 21] have been studied as extremely efficient electron acceptors in polymer and quantum dot solar cells [8]. Relatively new, dye sensitized solar cells are of great promise. In these devices, a nanocrystalline mesoporous titanium dioxide (TiO2) film, with a monolayer of the charge transfer dye attached to its surface, is pasted on a transparent conductive substrate [22, 23]. The large NM surface area for dye chemisorption and the short charge migration length underlie their power conversion efficiency [24, 25].

In addition to solar cells, nanotechnology has made big impact on fuel cells, devices able to convert chemical energy directly into electricity [24]. Nano-porous metals with high surface area, low specific densities and rich surface chemistry, can be highly efficient electro-catalysts for the critical electrode oxidation/reduction reactions in fuel cells [26, 27]. Platinum nanoparticles (Pt-NPs) have been regarded as the best cell catalyst, although the Pt-based electrode suffers from time-dependent drift and carbon monoxide deactivation [28]. In this regard, nano-sized multi (bi-tri)-metallic Pt alloys have been the object of further exploration because of their higher electro-catalytic activities and greater resistance [29, 30]. Interestingly, CNTs and graphene, initially used in fuel cells as attractive materials for catalyst supports with the aim to lower precious-metal loading, enhance catalyst activity and durability, are currently studied also as metal-free catalysts in fuel cells [3133]. Their advantages rely on high surface area, mesoporosity, good electrical conductivity, stronger mechanical strength, light weight and superb corrosion-resistance [27].

Another important future energy option is the hydrogen gas as an endless source of clean fuel for many applications [34]. Semiconductor NMs, e.g. TiO2 and cadmium sulfide nanostructures, have been studied as efficient catalysts for water conversion into oxygen and hydrogen [3537]. Moreover, nano-structured carbons, metal-organic frameworks and polymers [3841] as well as metal hydrides and related complex hydrides [42, 43] are examples of investigated NMs for hydrogen storage and transportation for high hydrogen capacity and minimal deterioration during hydrogenation.

Nanomaterials for energy storage

Nanotechnology may have a profound influence on electrical storage technologies, i.e. batteries and electrochemical supercapacitors [44]. Redox-based supercapacitors with nano-structured electrode materials have shown the potential to combine the high energy density of conventional batteries with the high power capabilities of electrostatic capacitors at the lab scale. Mixed metal oxides, e.g. ruthenium oxide (RuO2), manganese oxide (MnO2), magnetite (Fe3O4) [4547], CNTs [8, 48], graphene [49, 50] and carbon-metal oxide composites [51] have been investigated as electrode NMs aimed at a high specific capacity and rate capability [52, 53].

Concerning rechargeable lithium batteries, the energy densities and the performances of these devices largely depend on the physical and chemical properties of the electrode material [54]. In this regard, the reduced dimensions and high surface area of NMs increase the rate of electron transport and the electrode-electrolyte contact, respectively, while the nano-structure itself provides facile strain relaxation and resistance to fracture [24]. For anode applications, CNTs [8, 55, 56], a series of graphene-based nanostructures [21, 57, 58] and silicon nanowires [59] have been studied as promising host-high capacity materials and conductive additives. While emerging interests has been focused on metal oxide NMs, e.g. SnO2; TiO2 or LiFePO4-NMs, for anode or cathode applications [6063].

Nanomaterials for water clean-up technologies

Nanotechnology-enabled water and wastewater treatment promises not only to overcome major challenges faced by existing treatment technologies, but also to provide new treatment capabilities that could allow economic utilization of unconventional water sources to expand the water supply [64]. Interesting applications may include the incorporation of functional NMs, such as metal-oxide NPs (aluminium oxide, TiO2 and zeolite) [6567], anti-microbial NMs (silver-NPs (Ag-NPs) and CNTs) [68] and photocatalytic NMs (bimetallic-NPs, TiO2) [69, 70] into membranes in order to improve their permeability, fouling resistance, biofilm control, mechanical and thermal stability, as well as to provide pollutant degradation and self-cleaning ability [71]. Moreover, CNTs, fullerene and metal-based nano-adsorbents may offer significant improvement in the adsorption capacity of organic molecules, metal ions and heavy metals [7275]. Interestingly, due to the NM-unique electrochemical, optical, and magnetic properties, active research is going on developing nano-enabled pathogen sensors, both cells or biomolecules [76, 77].

Nanomaterials for construction industry

Manufactured NMs and nanocomposites offer great opportunities in the construction and related infrastructure industries [78]. Strength, durability, and lightness of various materials [79, 80], as well as heat-insulating, self-cleaning, fire-retardant, anti-fogging and sensing structural health properties may be improved or provided de novo by NMs [81, 82]. Thus, CNTs, SiO2, TiO2, Fe2O3, and magnetic nickel-NPs can remarkably improve mechanical durability, compressive and flexural strength of cement products [8386]. Highly water repellent coatings incorporating silica, alumina-NPs and hydrophobic polymers are proper to be used for wood [87]. The use of TiO2-NPs in glasses leads to the so-called self-cleaning technology due to their photo-catalytic and anti-fouling properties [81, 88]. Fire protective glass is obtained using silica (nano)layers, which may also function as antireflection coatings for exterior light in order to contribute to energy and air conditioning conservation [78, 89]. Ag-NPs can be embedded in paint to inactivate pathogenic microbes and provide antimicrobial properties to surfaces (e.g. hospital walls) [90].

Other nano-enhanced green applications

Several other sustainable nanotechnology applications have been investigated [91]. Nanoporous zeolites may be used as a slowly releasing carrier of fertilizers or as a permanent water reservoir due to their property to hold water molecules that may help plants to withstand dry spell [92]. Innovative NM properties may be useful in developing new-packaging to obtain films with good exfoliation, barrier, fireproofing and mechanical properties [93]. This application may permit to increase the shelf life of the food and its safety for consumers, especially in regions where cooling is not easily available. Nano-sensors can improve the quality and reduce the cost of continuous environmental monitoring [91, 94].

Occupational health and safety considerations

The unique properties of nano-scale materials have made them attractive for a number of innovative, sustainable, green applications. A summary of the example relationships among the guiding principles for a green economy, opportunities and practical challenges for nano-applications in a green economy is presented in Table 1.
Table 1

Example relationships among guiding principles for a green economy and the opportunities and challenges for nano-applications

Guiding principles for a green economy (based on the proposals of ref.[127])

(P1)

Is a means for achieving sustainable development;

(P2)

Creates decent work and green jobs;

(P3)

Improves governance and the rule of law – by being inclusive; democratic; participatory; accountable; transparent and stable;

(P4)

Is equitable, fair and just – between and within countries and between generations;

(P5)

Reduces poverty, and increases well-being, livelihoods, social protection, and access to essential services;

(P6)

Protects biodiversity and ecosystems;

(P7)

Is resource and energy efficient;

(P8)

Respects planetary boundaries or ecological limits or scarcity;

(P9)

Uses integrated decision making;

(P10)

Internalizes externalities;

(P11)

Measures beyond gross domestic product indicators and metrics

Example opportunities for nano-applications in a green economy (and the related principles)

Energy conversion and storage

-Smart energy nanotechnology can improve power delivery systems to be more efficient, reliable and safe (P1, P2, P5).

-Nano-devices may trade on renewable energy produced through naturally replenished resources, i.e. sunlight and wind. This may reduce fossils as energy resources and the impact for the greenhouse gas emissions balance (P3, P4, P5, P6, P7, P9).

-Energy efficient nanotechnology requires less energy to perform the same function - getting more use out of the already created energy (P7, P8, P10).

Water clean-up technologies

-Design nano-enabled infrastructure necessary to manage water and keep it clean is inextricably linked to prospects for economic development and better livelihood conditions (P1, P2).

-Access to clean water and adequate sanitation is a basic human right and is critical to the alleviation of poverty (P3, P4, P5).

-Investment in infrastructures and considerable greening of water policies are necessary to reduce the cost to face water shortages (P8, P9, P10, P11).

Construction industry

-Nanotechnology aims to increase the efficiency buildings use resources - energy, water, and materials - while reducing building impacts on environment and human health through better siting, design, construction, and removal (P1, P2, P6, P7, P8, P10, P11).

-NMs applied to the surfaces of structural elements of the buildings can contribute to environmental cleaning by photo-catalytic reactions (P1, P2, P6, P7, P8).

Other applications

-Nano-enabled applications may provide a slow release and dosage of fertilizers and an efficient water reservoir for plants. This may contribute to a greater agricultural productivity, especially in countries with prolonged dry spells (P1, P2, P4, P5).

-Nano-packaging - with improved barrier and mechanical properties - may allow a longer safe storage of food, especially in regions where cooling is not easily available (P2, P4, P5, P8).

-Nano-sensors may improve the quality and reduce the cost of continuous environmental monitoring. Nano-remediation of environmental pollution may exceed conventional methods in efficiency and speed (P1, P2, P6, P7).

Practical challenges for nano-applications in a green economy

Technical

-Efficient synthetic pathways must be developed to obtain NMs “safe by design” (e.g. through green chemistry; optimized reaction chemistry; minimized energy consumption and costs; employment of benign feed stocks and reagents; avoidance of hazardous substances and pollutants);

-Analytical methods must be developed to obtain a reliable nanomaterial characterization and tools to detect, monitor and track NMs in the environment and biological media.

Biological

-Biological impact must be determined for NM primary and acquired physico-chemical properties (size, surface area, chemical composition, protein corona as a nano-bio interaction) on ecosystems, as well as in in vitro and in vivo models;

-The “life-cycle” impact must be assessed for NMs on the environment and biological systems: NMs emitted from production processes, or released from nano-enabled devices during their assembly, use, recycling or disposal.

Health and safety

-NM key health effects must be defined: e.g. pulmonary toxicity, genotoxicity and carcinogenicity.

-Information must be developed on the potential toxicity of NMs available for employers and workers involved in NM research and developmental areas, as well as in nano-enabled device manufacture, assembly, application and disposal, avoiding dispersion of essential information.

-A highly skilled workforce must be built and sustained, that is well trained to face emerging risks as well as known physico-chemical risks in new situations and also trained to avoid accidents.

Public and occupational policies

-Participation of scientific, governmental, industry and workforce representatives must be pursued for the processes of opinion forming, education and decision making in shaping green nanotechnology.

-Nano-green jobs must redirect current path of environmental decline and create economic opportunity, strengthening local urban and rural communities.

-The green economy policies must balance nanotechnology environmental, societal, occupational and health promotion benefits, with commercialization costs and risks.

-Companies involved in green-nanotechnology innovations must plan a precautionary risk management approach by identifying actual risks, planning/implementing control measures and risk communication.

In this context according to the proposed principles for green economy, it is important that society, scientific community and industry take advantage of opportunities of nanotechnology while overcoming its practical challenges. However, not all revolutionary changes are sustainable per se and a cautious assessment of the benefits addressing economic, social and environmental implications, as well as the occupational health and safety impact is essential [95, 96]. This latter aspect, in particular, should be carefully addressed, in consideration of the expected widespread use of nanotechnology and the consequent increasing likelihood of NM exposure in both living and occupational environments. Moreover, difficulties in nano-manufacturing and handling; uncertainty concerning stability of nano-innovations under aggressive or long-term operation (i.e. in the case of supercapacitors with nano-structured electrode materials or nano-enabled construction products); the lack of information regarding the release and fate of NMs in the environment (i.e. NMs released from water and wastewater treatment devices) as well as the limited knowledge concerning the NM toxicological profile, even further support the need for a careful consideration of the health and safety risks derived from NM exposure.Importantly, as shown in Figure 1, a number of potentially hazardous exposure conditions can be expected for workers involved in nanotechnology activities. In fact, NMs may have significant, still unknown, hazards that can pose risks for a wide range of workers: researchers, laboratory technicians, cleaners, production workers, transportation, storage and retail workers, employees in disposal and waste facilities and potentially, emergency responders who deal with spills and disasters of NMs who may be differently exposed to these potential, innovative xenobiotics.
Figure 1

An analysis of potentially hazardous exposure conditions for workers involved in nanotechnology activities. Legend: Note how the recycling of nano-enabled products over time may result in changes in the composition of workplace exposures.

In this scenario, responsible green-nanotechnology development requires careful consideration of the possible lifecycle impact of NMs on the health of workers [97]. The earliest exposures to NMs may occur for those workers conducting discovery research in laboratories involved in designing, synthesizing and testing the usefulness of NMs in a variety of applications as well as in determining their toxicological and environmental impacts [98]. Workers in start-up and manufacturing companies involved in pilot processes can be exposed during several phases such as handling nano-powders, pouring or mixing nano-liquid solutions, recovering products from reactors or filters, conducting maintenance of equipment or rooms, cleaning spills or waste NMs or during processing, packaging and transporting of dry powder [99, 100]. The variability in composition, morphology and purity of NMs due to the developing methods of production, their dynamic behavior once dispersed in the workplace (e.g. agglomeration, aggregation, interaction with other airborne particles) and the large number of parameters required for their complete characterization, make NM exposure assessment a challenging issue [78, 91]. Furthermore, it may be extremely important to assess the exposure to “fresh” NMs, directly emitted from production processes, or “aged” NMs released during handling of packaged NMs, when assembling or maintaining nano-enhabled devices or released through wear and tear of nano-products [101104]. Ambient aging conditions, may cause NMs to undergo physical, chemical, and/or biological transformations that may change their properties and consequently their biological reactivity [78]. All these aspects impact the technical difficulties to routinely monitor, measure and characterize NMs in workplace settings principally related to the lack of easy to use instruments as well as to the difficulty in defining dose metric parameters, other than traditional mass, which may better reflect the NM biologically effective dose in the nano-toxicological field [102, 105, 106].

Workers should also be aware of their potential exposure to NMs or products containing them during the disposal stage [100]. Laboratories, industries, and disposal of products containing NMs may produce new forms of waste that could challenge current waste management, product re-use and recycling efforts. When addressing the issue of occupational NM exposure in these contexts, a variety of factors should be carefully considered. The intrinsic potential of different devices to release NMs, the possible disposal pathways for specific nano-waste, (e.g. waste-water, landfill, incineration or recycling), the bioavailability and persistence of NMs, and subsequent effect in and across the disposal media such as air, soil and water all need specific attention [100].

Nano-enhanced technologies may lead to “emerging occupational and safety risks” principally related to the exposure to candidate NMs whose toxicological behaviors and mechanisms of biological reactivity are still under research. In this regard, scientific concerns raised in consideration of the preliminary results demonstrating the pro-oxidant and pro-inflammatory action of several types of engineered NMs in vitro[107109] and also their ability to induce alterations in organs such as lung, cardiovascular and central nervous system following acute to chronic periods of treatment in vivo[110112]. Recent evidence of the occupational carcinogenic potential of inhaled TiO2-NPs [113], we previously mentioned as components of innovative solar cells or of self cleaning construction products, the uncertainty concerning whether some types of CNTs, which may find widespread employment in a series of energy conversion and storage devices, may be carcinogenic [114], as well as the possibility of not recognizing long latency hazards of innovative materials heighten these concerns. Therefore, new demanding green nanotechnologies will need a highly skilled workforce, well trained in specific skills necessary to perform these jobs, as well as in recognizing risks and taking occupational safety and health measures to reduce risks induced by new processes and products. This ambitious aim will require large scientific efforts to overcome the current lack of knowledge concerning NM hazardous properties as well as governmental engagement and empowerment of workers aimed to “assure/make sure” workforce education and regulation in order to reach suitable employee expertise, good workplace practices and adequate health protection. Importantly, a comprehensive approach to prevention and protection strategies in green nanotechnologies should take into account also the relevance that a careful assessment and management of “known” physico-chemical risks, intrinsically related to the manufacture, installation, maintenance and disposal of nano-enabled products, may have for the health and safety of workers.

Green nanotechnology: risk assessment, management and communication

The newness of nano-applications in green fields, together with concerns regarding the potential impact of NMs on the health and safety of workers, urgently require scientific, technological and governmental efforts to actively manage risks for the workforce. This means to identify actual risks derived from NM exposure in workplace (risk assessment), to plan/implement control measures (risk management) and to communicate the plan. Overall, these steps, whose critical aspects will be discussed in the following sections, aim to prevent workers to be harmed and society deprived of the timely realization of all the benefits of the nanotechnology.

Risk assessment

Risk assessment of NMs notably includes the same steps used for the risk assessment of other types of chemicals [102]. These are: hazard identification; hazard characterization with an emphasis on defining critical target organs and dose-response relationships; assessment of exposure for different scenarios and a synthesizing step risk characterization [115].

Unfortunately, the NM risk assessment process still suffers from a lack of toxicological data on a wide variety of NMs. Therefore, future research should be aimed to systematically improve the understanding of metrics, such as size, surface area, functionalization or particle number concentration, that may be responsible for NM toxicity. The toxico-kinetic and toxico-dynamic behaviour of NMs in biological systems, including the influences exerted by the protein corona formation, as the result of a dynamic nano-bio interaction, should be deeply investigated. Moreover, the definition of key health effects such as pulmonary toxicity, genotoxicity or carcinogenicity in conditions of long-term, low-dose exposure resembling realistic scenarios, require attention [116]. Exposure assessment remains a fundamental condition for the characterization of occupational NM risks [106, 114, 115]. Thus, efforts should be made to overcome practical barriers related to the newness of green-NM exposure scenarios, the inconsistencies over how to identify and classify NMs, and the questions about metrics for health related-sampling and practical instrumentation [117]. Moreover, biological monitoring studies, are also important to define possible biomarkers of NM exposure and effect to be prospectively tested and validated in workplace settings and used for an adequate evaluation of occupational risks [118].

Risk management

The ultimate goal of risk assessment is to provide quantitative predictions of given risks enabling their evidence-based management [102]. However, vast uncertainty about hazards, exposures, and risks in the emerging green nanotechnology field, make it imperative to adopt a dynamic-precautionary management approach before all of the evidence is completed. This means that risk management strategies and guidance will be changing and continuously evaluated, improved, and verified as risk information becomes more substantial [97].

To effectively manage potential green nanotechnology related risks, a risk management plan including a hierarchy of controls should be emphasized [119]. The first step in developing such a plan is to determine which workers may have potential exposures, measuring these exposures and identifying how the exposure may vary depending on the job task (as illustrated in Figure 1). Potential worker exposures should be managed using the hierarchy of controls starting with elimination of the hazard, adopting a green chemistry through the substitution with a non-hazardous or less hazardous alternative (such as modifying the molecule if possible), and introduction of engineering controls such as enclosed systems, local exhaust ventilation, engineering hood or pressure differentials [120]. These steps should be followed by administrative controls, including training programs through which companies communicate to workers information sufficient to understand the nature and routes of potential NM workplace exposure, possible risks, adequate job procedures, preventive and protective measures and policies adopted. In this context, it may be important to overcome the frequently insufficient or inadequate information present on safety data sheets [121]. The use of personal protective equipment (PPE), such as respiratory and eye protection, lab coats and gloves, should be addressed as the final step for exposure control because the use of PPE puts the responsibility on the employee instead of the employer [119]. Among these primary preventive measures, greater efforts should also be targeted to pursue the ambitious attempt to adopt sustainable practices, throughout the lifecycle and value chain of NMs, which may allow to design production processes able to reduce exposure and to obtain less toxic NMs, ”safe by design” [120]. Good business practice includes planning for controlling possible exposure scenarios during the design process as this is frequently less expensive than retrofitting existing process equipment. Aligning safety goals with business goals can improve the profitability of the business by protecting the employee skill, experience and knowledge; reducing production delays; and reducing any costs associated with employee injuries.

Occupational health surveillance can be a useful component of a NM risk management plan, which includes elements of hazard and medical surveillance [114, 117]. Monitoring of health outcomes or biological changes including medical surveillance of the effects at group and individual levels is part of an occupational health surveillance program [122, 123]. Medical surveillance may include: (i) an initial medical examination and collection of medical and occupational histories; (ii) periodic medical examinations at regularly scheduled intervals, including specific medical screening tests when warranted; (iii) more frequent and detailed medical examinations as indicated on the basis of findings from these examinations; (iv) post-incident examinations and medical screening following uncontrolled or non-routine increases in exposures such as spills; (v) worker training to recognize and report symptoms of exposure to a given hazard, (vi) a written report of medical findings; and (vii) employer actions in response to identification of potential hazards and risks to health [124].

Epidemiological research may be useful to enhance the impact of occupational health surveillance through the periodic analysis of aggregated data in order to identify patterns of worker health that may be linked to work activities and practices [114, 121, 125]. Exposure registries may be useful in setting the stage for this kind of research. Registries are important to enumerate and identify exposed individuals, to provide them with adequate information and guidance as well as with primary or secondary prevention measures concerning potential NM exposure risks [117].

Risk communication

Risk communication, is essential for the healthy innovation and sustainable development of green nanotechnology in view of a general public transparency [126]. In this context, risk communication should become effective in terms of making available complex technical and health information in language accessible and understandable to the occupational and general population. Importantly, researchers, regulatory scientists, representatives of the workforce, industry and governmental authorities should be actively engaged in facing a dialogical pro-active communication of the potential nanotechnology risks with the aim to form adequate perceptions and attitudes. This appears extremely important to assure the spread, also promoted by mass media, of appropriate information regarding benefits and challenges of nanotechnology, protecting public and personnel opinion from both unrealistic hopes and excessive awareness in this regard.

Conclusions

Green nanotechnology aims to exploit the attractive physico-chemical properties of NMs in a number of green-innovative applications that are energy efficient as well as economically and environmentally sustainable, expected to exert an exciting impact on a large range of economic sectors. These solutions may offer the opportunities to reduce pressure on raw materials trading on renewable energy, to improve power delivery systems to be more reliable, efficient and safe as well as to use unconventional water sources or nano-enabled construction products therefore providing better ecosystem and livelihood conditions [127]. However the opportunities offered by NMs in green economy solutions, should be balanced with a number of practical challenges, critical environmental and social issues, as well as with human health and safety concerns. In particular, NMs may have significant, still unknown, hazardous properties related to their unique physico-chemical properties, that can pose risks for a wide range of employees potentially exposed through the overall lifecycle of NMs. Therefore, scientific research, technological, governmental and workforce efforts should be focused to deeply define the hazardous impact of NMs with the aim to reach an adequate risk assessment. This would provide helpful information and guidance to adopt appropriate preventive and protective measures in a comprehensive risk management program both for the general and occupationally exposed populations.

Overall, green nanotechnology should not only provide green solutions, but should also “become green” in terms of the attention paid to occupational safety and health. In this context, a full democratic discussion between expertise should be pursued to carefully balance the benefits of green nanotechnology and the potential costs for the society, particularly in terms of environmental, public and occupational health. This careful consideration will maximize environmental and societal benefits, health gains and cost savings and will increase the likelihood of further investment and sustainable development of this promising technological field.

Abbreviations

Ag-NPs: 

Silver nanoparticles

CNTs: 

Carbon nanotubes

NMs: 

Nanomaterials

NPs: 

Nanoparticles

PPE: 

Personal protective equipment

Pt-NPs: 

Platinum nanoparticles

TiO2

Titanium dioxide.

Declarations

Acknowledgements

The authors thank Paul A. Schulte for early discussion on this work, critical revisions of the manuscript, precious comments and assistance.

Disclaimer

The findings and conclusions in this report are those of authors and do not necessarily represent the views of their respective organizations.

Authors’ Affiliations

(1)
Institute of Public Health, Catholic University of the Sacred Heart, Rome, Italy
(2)
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, USA
(3)
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, USA

References

  1. Pearce DW, Markandya A, Barbier ER: Blueprint for a Green Economy. 1989, London: Earthscan Publications LtdGoogle Scholar
  2. International Energy Agency: World Energy Outlook 2012. Paris: International Energy Agency, Available at http://www.iea.org/publications/freepublications/publication/English.pdf
  3. European Environment Agency: Towards a Green Economy in Europe- EU Environmental Policy Targets and Objectives 2010-2050. EEA Report No 8/2013.http://www.eea.europa.eu/publications/towards-a-green-economy-in-europe,
  4. United Nations Environment Programme: Green Economy Report. Towards a Green Economy: Pathways to Sustainable Development and Poverty Eradication. 2011,http://www.unep.org/greeneconomy/greeneconomyreport/tabid/29846/default.aspx,Google Scholar
  5. Economic Commission for Latin America and the Caribbean: A Green Economy: Introduction To The Debate And Implications for Latin America and Caribbean. 2010,http://www.cepal.org/dmaah/noticias/noticias/4/41684/DraftDiscussionPaper.pdf,Google Scholar
  6. European Environment Agency: The European Environment – State And Outlook 2010: Synthesis. State of The Environment Report No 1/2010.http://www.eea.europa.eu/soer/synthesis/,
  7. Organisation for Economic Co-operation and Development: Interim Report of the Green Growth Strategy: Implementing Our Commitment For A Sustainable Future. 2010,http://www.oecd.org/greengrowth/45312720.pdf,Google Scholar
  8. Dai L, Chang DW, Baek JB, Lu W: Carbon nanomaterials for advanced energy conversion and storage. Small. 2012, 8: 1130-1166. 10.1002/smll.201101594.Google Scholar
  9. Handy RD, Shaw BJ: Toxic effects of nanoparticles and nanomaterials: implications for public health, risk assessment and the public perception of nanotechnology. Health Risk Soc. 2007, 9: 125-144. 10.1080/13698570701306807.Google Scholar
  10. Ling MP, Chio CP, Chou WC, Chen WY, Hsieh NH, Lin YJ, Liao CM: Assessing the potential exposure risk and control for airborne titanium dioxide and carbon black nanoparticles in the workplace. Environ Sci Pollut Res Int. 2011, 8: 877-889.Google Scholar
  11. Li N, Nel AE: Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research. J Occup Environ Med. 2011, 53 (suppl 6): S74-S79.Google Scholar
  12. Organisation for Economic Co-operation and Development: OECD/NNI International Symposium on Assessing the Economic Impact of Nanotechnology Background Paper 3: The Economic Contributions of Nanotechnology to Green and Sustainable Growth. 2012, In http://www.oecd.org/sti/nano/49932107.pdf Google Scholar
  13. Organisation for Economic Co-operation and Development: Nanotechnology for Green Innovation. 2013,http://search.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=DSTI/STP/NANO(2013)3/FINAL&docLanguage=En,Google Scholar
  14. Rickerby DG, Morrison M: Nanotechnology and the environment: a European perspective. Sci Technol Adv Mat. 2007, 8: 19-24. 10.1016/j.stam.2006.10.002.Google Scholar
  15. Lewis NS: Toward cost-effective solar energy use. Science. 2007, 315: 798-801. 10.1126/science.1137014.Google Scholar
  16. Sariciftci NS, Smilowitz L, Heeger AJ, Wudl F: Photoinduced electron transfer from a conducting polymer to buckminsterfullerene. Science. 1992, 258: 1474-1476. 10.1126/science.258.5087.1474.Google Scholar
  17. He Y, Li Y: Fullerene derivative acceptors for high performance polymer solar cells. Phys Chem Chem Phys. 2011, 13: 1970-1983. 10.1039/c0cp01178a.Google Scholar
  18. Hecht DS, Hu L, Irvin G: Emerging transparent electrodes based on thin films of carbon nanotubes, graphene, and metallic nanostructures. Adv Mater. 2011, 23: 1482-1513. 10.1002/adma.201003188.Google Scholar
  19. Somani PR, Somani SP, Flahaut E, Umeno M: Improving the photovoltaic response of a poly(3-octylthiophene)/n-Si heterojunction by incorporating double-walled carbon nanotubes. Nanotechnology. 2007, 18: 185708-10.1088/0957-4484/18/18/185708.Google Scholar
  20. Novoselov KS, Geim AK, Morozov SV, Jiang D, Zhang Y, Dubonos SV, Grigorieva IV, Firsov AA: Electric field effect in atomically thin carbon films. Science. 2004, 306: 666-669. 10.1126/science.1102896.Google Scholar
  21. Luo B, Liu S, Zhi L: Chemical approaches toward graphene-based nanomaterials and their applications in energy-related areas. Small. 2012, 8: 630-646. 10.1002/smll.201101396.Google Scholar
  22. Hagfeldt A, Boschloo G, Sun L, Kloo L, Pettersson H: Dye-sensitized solar cells. Chem Rev. 2010, 110: 6595-6663. 10.1021/cr900356p.Google Scholar
  23. Hagfeldt A: Brief overview of dye-sensitized solar cells. Ambio. 2012, 41 (Suppl 2): 151-155.Google Scholar
  24. Chen X, Li C, Grätzel M, Kostecki R, Mao SS: Nanomaterials for renewable energy production and storage. Chem Soc Rev. 2012, 41: 7909-7937. 10.1039/c2cs35230c.Google Scholar
  25. Zukalová M, Zukal A, Kavan L, Nazeeruddin MK, Liska P, Grätzel M: Organized mesoporous TiO2 films exhibiting greatly enhanced performance in dye-sensitized solar cells. Nano Lett. 2005, 5: 1789-1792. 10.1021/nl051401l.Google Scholar
  26. Zhang J, Li CM: Nanoporous metals: fabrication strategies and advanced electrochemical applications in catalysis, sensing and energy systems. Chem Soc Rev. 2012, 41: 7016-7031. 10.1039/c2cs35210a.Google Scholar
  27. Qiao Y, Li CM: Nanostructured catalysts in fuel cells. J Mater Chem. 2011, 21: 4027-4036. 10.1039/c0jm02871a.Google Scholar
  28. Zhong CJ, Luo J, Fang B, Wanjala BN, Njoki PN, Loukrakpam R, Yin J: Nanostructured catalysts in fuel cells. Nanotechnology. 2010, 21: 062001-10.1088/0957-4484/21/6/062001.Google Scholar
  29. Wang JX, Inada H, Wu L, Zhu Y, Choi Y, Liu P, Zhou WP, Adzic RR: Oxygen reduction on well-defined core-shell nanocatalysts: particle size, facet, and Pt shell thickness effects. J Am Chem Soc. 2009, 131: 17298-17302. 10.1021/ja9067645.Google Scholar
  30. Mazumder V, Chi M, More KL, Sun S: Core/shell Pd/FePt nanoparticles as an active and durable catalyst for the oxygen reduction reaction. J Am Chem Soc. 2010, 132: 7848-7849. 10.1021/ja1024436.Google Scholar
  31. Antolini E: Carbon supports for low-temperature fuel cell catalysts. Appl Catal B-Environ. 2009, 88: 1-24. 10.1016/j.apcatb.2008.09.030.Google Scholar
  32. Yu DS, Nagelli E, Du F, Dai LM: Metal-free carbon nanomaterials become more active than metal catalysts and last longer. J Phis Chem Lett. 2010, 1: 2165-2173. 10.1021/jz100533t.Google Scholar
  33. Qu X, Alvarez PJ, Li Q: Applications of nanotechnology in water and wastewater treatment. Water Res. 2013, 47: 3931-3946. 10.1016/j.watres.2012.09.058.Google Scholar
  34. Chen X, Shen S, Guo L, Mao SS: Semiconductor-based photocatalytic hydrogen generation. Chem Rev. 2010, 110: 6503-6570. 10.1021/cr1001645.Google Scholar
  35. Chen X, Liu L, Yu PY, Mao SS: Increasing solar absorption for photocatalysis with black hydrogenated titanium dioxide nanocrystals. Science. 2011, 331: 746-750. 10.1126/science.1200448.Google Scholar
  36. Wu H, Zhang Z: High photoelectrochemical water splitting performance on nitrogen doped double-wall TiO2 nanotube array electrodes. Int J Hydrogen Energy. 2011, 36: 13481-13487. 10.1016/j.ijhydene.2011.08.014.Google Scholar
  37. Li Y, Hu Y, Peng S, Lu G, Li S: Synthesis of CdS nanorods by an ethylenediamine assisted hydrothermal method for photocatalytic hydrogen evolution. J Phys Chem C. 2009, 113: 9352-9358.Google Scholar
  38. Zuttel A, Sudan P, Mauron P, Kiyobayashi T, Emmenegger C, Schlapbach L: Hydrogen storage in carbon nanostructures. Int J Hydrogen Energy. 2002, 27: 203-212.Google Scholar
  39. Hirscher M, Becher M: Hydrogen storage in carbon nanotubes. J Nanosci Nanotechnol. 2003, 3: 3-17. 10.1166/jnn.2003.172.Google Scholar
  40. Rosi NL, Eckert J, Eddaoudi M, Vodak DT, Kim J, O’Keeffe M, Yaghi OM: Hydrogen storage in microporous metal-organic frameworks. Science. 2003, 300: 1127-1129. 10.1126/science.1083440.Google Scholar
  41. Germain J, Fréchet JM, Svec F: Nanoporous polymers for hydrogen storage. Small. 2009, 5: 1098-1111. 10.1002/smll.200801762.Google Scholar
  42. Orimo S, Nakamori Y, Eliseo JR, Züttel A, Jensen CM: Complex hydrides for hydrogen storage. Chem Rev. 2007, 107: 4111-4132. 10.1021/cr0501846.Google Scholar
  43. Jeon KJ, Moon HR, Ruminski AM, Jiang B, Kisielowski C, Bardhan R, Urban JJ: Air-stable magnesium nanocomposites provide rapid and high-capacity hydrogen storage without using heavy-metal catalysts. Nat Mater. 2011, 10: 286-290. 10.1038/nmat2978.Google Scholar
  44. Zhao X, Sánchez BM, Dobson PJ, Grant PS: The role of nanomaterials in redox-based supercapacitors for next generation energy storage devices. Nanoscale. 2011, 3: 839-855. 10.1039/c0nr00594k.Google Scholar
  45. Ke YF, Tsai DS, Huang YS: Electrochemical capacitors of RuO2 nanophase grown on LiNbO3(100) and sapphire(0001) substrates. J Mater Chem. 2005, 15: 2122-2127. 10.1039/b502754c.Google Scholar
  46. Hu CC, Chang KH, Lin MC, Wu YT: Design and tailoring of the nanotubular arrayed architecture of hydrous RuO2 for next generation supercapacitors. Nano Lett. 2006, 6: 2690-2695. 10.1021/nl061576a.Google Scholar
  47. Yu C, Zhang L, Shi J, Zhao J, Gao J, Yan D: A simple template-free strategy to synthesize nanoporous manganese and nickel oxides with narrow pore size distribution, and their electrochemical properties. Adv Funct Mater. 2008, 18: 1544-1554. 10.1002/adfm.200701052.Google Scholar
  48. Kaempgen M, Chan CK, Ma J, Cui Y, Gruner G: Printable thin film supercapacitors using single-walled carbon nanotubes. Nano Lett. 2009, 9: 1872-1876. 10.1021/nl8038579.Google Scholar
  49. Kim TY, Lee HW, Stoller M, Dreyer DR, Bielawski CW, Ruoff RS, Suh KS: High-performance supercapacitors based on poly(ionic liquid)-modified grapheme electrodes. ACS Nano. 2011, 5: 436-442. 10.1021/nn101968p.Google Scholar
  50. Huang Y, Liang J, Chen Y: An overview of the applications of graphene-based materials in supercapacitors. Small. 2012, 8: 1805-1834. 10.1002/smll.201102635.Google Scholar
  51. Zhi M, Xiang C, Li J, Li M, Wu N: Nanostructured carbon-metal oxide composite electrodes for supercapacitors: a review. Nanoscale. 2013, 5: 72-88. 10.1039/c2nr32040a.Google Scholar
  52. Liu CG, Liu M, Li F, Cheng HM: Frequency response characteristic of single-walled carbon nanotubes as supercapacitor electrode material. Appl Phys Lett. 2008, 92: 143108-10.1063/1.2907501.Google Scholar
  53. Liu J, Cao G, Yang Z, Wang D, Dubois D, Zhou X, Graff GL, Pederson LR, Zhang JG: Oriented nanostructures for energy conversion and storage. Chem Sus Chem. 2008, 1: 676-697. 10.1002/cssc.200800087.Google Scholar
  54. Liu C, Li F, Ma LP, Cheng HM: Advanced materials for energy storage. Adv Mater. 2010, 22: E28-62. 10.1002/adma.200903328.Google Scholar
  55. Frackowiak E, Beguin F: Electrochemical storage of energy in carbon nanotubes and nanostructured carbons. Carbon. 2002, 40: 1775-1787. 10.1016/S0008-6223(02)00045-3.Google Scholar
  56. Centi G, Perathoner S: Carbon nanotubes for sustainable energy applications. Chem Sus Chem. 2011, 4: 913-925. 10.1002/cssc.201100084.Google Scholar
  57. Lian P, Zhu X, Liang S, Li Z, Yang W, Wang H: Large reversible capacity of high quality graphene sheets as an anode material for lithium-ion batteries. Electrochim Acta. 2010, 55: 3909-3914. 10.1016/j.electacta.2010.02.025.Google Scholar
  58. Guo P, Song H, Chen X: Electrochemical performance of graphene nanosheets as anode material for lithium-ion batteries. Electrochem Commun. 2009, 11: 1320-1324. 10.1016/j.elecom.2009.04.036.Google Scholar
  59. Chan CK, Peng H, Liu G, McIlwrath K, Zhang XF, Huggins RA, Cui Y: High-performance lithium battery anodes using silicon nanowires. Nat Nanotechnol. 2008, 3: 31-35. 10.1038/nnano.2007.411.Google Scholar
  60. Hu YS, Kienle L, Guo YG, Maier J: High lithium electroactivity of nanometer-sized rutile TiO2. Adv Mater. 2006, 18: 1421-1426. 10.1002/adma.200502723.Google Scholar
  61. Saji VS, Kim YS, Kim TH, Cho J, Song HK: One-dimensional (1D) nanostructured and nanocomposited LiFePO4: its perspective advantages for cathode materials of lithium ion batteries. Phys Chem Chem Phys. 2011, 13: 19226-19237. 10.1039/c1cp22818h.Google Scholar
  62. Wang Z, Zhou L, Lou XW: Metal oxide hollow nanostructures for lithium-ion batteries. Adv Mater. 2012, 24: 1903-1911. 10.1002/adma.201200469.Google Scholar
  63. Chen JS, Lou XW: SnO2-based nanomaterials: synthesis and application in lithium-ion batteries. Small. 2013, 9: 1877-1893. 10.1002/smll.201202601.Google Scholar
  64. Qu XL, Brame J, Li Q, Alvarez JJP: Nanotechnology for a safe and sustainable water supply: enabling integrated water treatment and reuse. Accounts Chem Res. 2013, 46: 834-843. 10.1021/ar300029v.Google Scholar
  65. Maximous N, Nakhla G, Wong K, Wan W: Optimization of Al(2)O(3)/PES membranes for wastewater filtration. Sep Purif Technol. 2010, 73: 294-301. 10.1016/j.seppur.2010.04.016.Google Scholar
  66. Pendergast MTM, Nygaard JM, Ghosh AK, Hoek EMV: Using nanocomposite materials technology to understand and control reverse osmosis membrane compaction. Desalination. 2010, 261: 255-263. 10.1016/j.desal.2010.06.008.Google Scholar
  67. Bae TH, Tak TM: Effect of TiO2 nanoparticles on fouling mitigation of ultrafiltration membranes for activated sludge filtration. J Membrane Sci. 2005, 249: 1-8. 10.1016/j.memsci.2004.09.008.Google Scholar
  68. Hossain F, Perales-Perez OJ, Hwang S, Román F: Antimicrobial nanomaterials as water disinfectant: Applications, limitations and future perspectives. Sci Total Environ. 2013, 466-467C: 1047-1059.Google Scholar
  69. Chin SS, Chiang K, Fane AG: The stability of polymeric membranes in a TiO2 photocatalysis process. J Membrane Sci. 2006, 275: 202-211. 10.1016/j.memsci.2005.09.033.Google Scholar
  70. Wu LF, Ritchie SMC: Enhanced dechlorination of trichloroethylene by membrane-supported Pd-coated iron nanoparticles. Environ Prog. 2008, 27: 218-224. 10.1002/ep.10277.Google Scholar
  71. Qu L, Liu Y, Baek JB, Dai L: Nitrogen-doped graphene as efficient metal-free electrocatalyst for oxygen reduction in fuel cells. ACS Nano. 2010, 4: 1321-1326. 10.1021/nn901850u.Google Scholar
  72. Sharma YC, Srivastava V, Singh VK, Kaul SN, Weng CH: Nano-adsorbents for the removal of metallic pollutants from water and wastewater. Environ Technol. 2009, 30: 583-609. 10.1080/09593330902838080.Google Scholar
  73. Ali I: New generation adsorbents for water treatment. Chem Rev. 2012, 112: 5073-5091. 10.1021/cr300133d.Google Scholar
  74. Gupta VK, Saleh TA: Sorption of pollutants by porous carbon, carbon nanotubes and fullerene- an overview. Environ Sci Pollut Res Int. 2013, 20: 2828-2843. 10.1007/s11356-013-1524-1.Google Scholar
  75. Hua M, Zhang S, Pan B, Zhang W, Lv L, Zhang Q: Heavy metal removal from water/wastewater by nanosized metal oxides: a review. J Hazard Mater. 2012, 211–212: 317-331.Google Scholar
  76. Vikesland PJ, Wigginton KR: Nanomaterial enabled biosensors for pathogen monitoring: a review. Env Sci Technol. 2010, 44: 3656-3669. 10.1021/es903704z.Google Scholar
  77. Theron J, Eugene Cloete T, de Kwaadsteniet M: Current molecular and emerging nanobiotechnology approaches for the detection of microbial pathogens. Crit Rev Microbiol. 2010, 36: 318-339. 10.3109/1040841X.2010.489892.Google Scholar
  78. Lee J, Mahendra S, Alvarez PJ: Nanomaterials in the construction industry: a review of their applications and environmental health and safety considerations. ACS Nano. 2010, 4: 3580-3590. 10.1021/nn100866w.Google Scholar
  79. Mann S: Nanotechnology and Construction. Nanoforum Report. 2006,http://nanotech.law.asu.edu/Documents/2009/10/Nanotech%20and%20Construction%20Nanoforum%20report_259_9089.pdf,Google Scholar
  80. Sobolev K, Gutierrez MF: How nanotechnology can change the concrete world. Am Ceram Soc Bull. 2005, 84: 16-20.Google Scholar
  81. Irie H, Sunada K, Hashimoto K: Recent developments in TiO2 photocatalysis: novel applications to interior ecology, materials and energy saving systems. Electrochemistry. 2004, 72: 807-812.Google Scholar
  82. Zhang W, Suhr J, Koratkar N: Carbon nanotube/polycarbonate composites as multifunctional strain sensors. J Nanosci Nanotechnol. 2006, 6: 960-964. 10.1166/jnn.2006.171.Google Scholar
  83. Li GY: Properties of high-volume fly ash concret incorporating nano-SiO2. Cem Concr Res. 2004, 34: 1043-1049. 10.1016/j.cemconres.2003.11.013.Google Scholar
  84. Guskos N, Zolnierkiewicz G, Typek J, Blyszko J, Kiernozycki W, Narkiewicz U: Ferromagnetic resonance and compressive strength study of cement mortars containing carbon encapsulated nickel and iron nanoparticles. Rev Adv Mater Sci. 2010, 23: 113-117.Google Scholar
  85. Wang B, Han Y, Zhang T: Morphological properties of surface-treated carbon nanotubes in cement-based composites. J Nanosci Nanotechnol. 2012, 12: 8415-8419. 10.1166/jnn.2012.6635.Google Scholar
  86. Khataee R, Heydari V, Moradkhannejhad L, Safarpour M, Joo SW: Self-cleaning and mechanical properties of modified white cement with nanostructured TiO2. J Nanosci Nanotechnol. 2013, 13: 5109-5114. 10.1166/jnn.2013.7586.Google Scholar
  87. Olar R: Nanomaterials and nanotechnologies for civil engineering. Bul Ist Polit Iasit. 2011, 57: 4-Google Scholar
  88. Zhu W, Bartos PJM, Porro A: Application of nanotechnology in construction. summary of a state of the art report. Mater Struct. 2004, 37: 649-658.Google Scholar
  89. Rana AK, Rana SB, Kumari A, Kiran V: Significance of nanotechnology in construction engineering. Int J Recent Trends Eng. 2009, 1: 46-48.Google Scholar
  90. Kumar A, Vemula PK, Ajayan PM, John G: Silver- nanoparticle-embedded antimicrobial paints based on vegetable oil. Nat Mater. 2008, 7: 236-241. 10.1038/nmat2099.Google Scholar
  91. Fleischer T, Grunwald A: Making nanotechnology developments sustainable. A role for technology assessment?. J Clean Prod. 2008, 16: 889-898. 10.1016/j.jclepro.2007.04.018.Google Scholar
  92. Remesh K, Biswas AS, Somasundaram J, Rao AS: Nanoporous zeolites in framing: current status and issues ahead. Curr Sci. 2010, 99: 760-764.Google Scholar
  93. de Abreu DA P, Paseiro Losada P, Angulo I, Cruz JM: Development of new polyolefin films with nanoclays for application in food packaging. Eur Polymer J. 2007, 43: 2229-2243. 10.1016/j.eurpolymj.2007.01.021.Google Scholar
  94. Andreescu S, Njagi J, Ispas C, Ravalli MT: JEM Spotlight: Applications of advanced nanomaterials for environmental monitoring. J Environ Monit. 2009, 11: 27-40. 10.1039/b811063h.Google Scholar
  95. Bauer C, Buchgeister J, Hischier R, Poganietz WR, Schebek L, Warsen J: Towards a framework for life cycle thinking in the assessment of nanotechnology. J Clean Prod. 2008, 16: 910-926. 10.1016/j.jclepro.2007.04.022.Google Scholar
  96. Hutchison JE: Greener nanoscience: a proactive approach to advancing applications and reducing implications of nanotechnology. ACS Nano. 2008, 2: 395-402. 10.1021/nn800131j.Google Scholar
  97. Schulte PA, Geraci CL, Hodson LL, Zumwalde RD, Kuempel ED, Murashov V, Martinez KF, Heidel DS: Overview of Risk Management for Engineered Nanomaterials. J Phys Conf Ser. 2013, 429: 012062-Google Scholar
  98. National Institute for Occupational Safety and Health: General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories. Publication No. 2012-147. Cincinnati, Ohio, USA: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH),http://www.cdc.gov/niosh/docs/2012-147/pdfs/2012-147.pdf,
  99. Schulte PA, Geraci C, Zumwalde R, Hoover M, Kuempel E: Occupational risk management of engineered nanoparticles. J Occup Environ Hyg. 2008, 5: 239-249. 10.1080/15459620801907840.Google Scholar
  100. Ponce Del Castillo AM: Nanomaterials And Workplace Health & Safety. What Are The Issues For Workers?. European Trade Union Institute,http://www.etui.org/Publications2/Guides/Nanomaterials-and-workplace-health-safety.-What-are-the-issues-for-workers,
  101. Seipenbusch M, Binder A, Kasper G: Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg. 2008, 52: 707-716. 10.1093/annhyg/men067.Google Scholar
  102. Savolainen K, Alenius H, Norppa H, Pylkkänen L, Tuomi T, Kasper G: Risk assessment of engineered nanomaterials and nanotechnologies - a review. Toxicology. 2010, 269: 92-104. 10.1016/j.tox.2010.01.013.Google Scholar
  103. Hsu LY, Chein HM: Evaluation of nanoparticle emission for TiO2 nanopowder coating materials. J Nanopart Res. 2007, 9: 157-163.Google Scholar
  104. Aschberger K, Micheletti C, Sokull-Klüttgen B, Christensen FM: Analysis of currently available data for characterising the risk of engineered nanomaterials to the environment and human health–lessons learned from four case studies. Environ Int. 2011, 37: 1143-1156. 10.1016/j.envint.2011.02.005.Google Scholar
  105. Iavicoli I, Leso V, Fontana L, Cottica D, Bergamaschi A: Characterization of inhalable, thoracic, and respirable fractions and ultrafine particle exposure during grinding, brazing, and welding activities in a mechanical engineering factory. J Occup Environ Med. 2013, 55: 430-445. 10.1097/JOM.0b013e31827cbabe.Google Scholar
  106. National Institute for Occupational Safety and Health: Approaches to Safe Nanotechnology. Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. Publication No. 2009-125. Cincinnati, Ohio, USA: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH),http://www.cdc.gov/niosh/docs/2009-125/pdfs/2009-125.pdf,
  107. Andujar P, Lanone S, Brochard P, Boczkowski J: Respiratory effects of manufactured nanoparticles. Rev Mal Respir. 2011, 28: e66-75. 10.1016/j.rmr.2011.09.008.Google Scholar
  108. Iavicoli I, Leso V, Fontana L, Bergamaschi A: Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. Eur Rev Med Pharmacol Sci. 2011, 15: 481-508.Google Scholar
  109. Horie M, Kato H, Fujita K, Endoh S, Iwahashi H: In vitro evaluation of cellular response induced by manufactured nanoparticles. Chem Res Toxicol. 2012, 25: 605-619. 10.1021/tx200470e.Google Scholar
  110. Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL: A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol. 2006, 36: 189-217. 10.1080/10408440600570233.Google Scholar
  111. Iavicoli I, Leso V, Bergamaschi A: Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies. J Nanomater. 2012, 2012: 964381-Google Scholar
  112. Sharma HS, Sharma A: Neurotoxicity of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets. 2012, 11: 65-80. 10.2174/187152712799960817.Google Scholar
  113. National Institute for Occupational Safety and Health: Occupational Exposure to Titanium Dioxide. Publication No. 2011-160. Cincinnati, Ohio, USA: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH),http://www.cdc.gov/niosh/docs/2011-160/pdfs/2011-160.pdf,
  114. National Institute for Occupational Safety and Health: Occupational Exposure to Carbon Nanotubes and Nanofibers. Publication No. 2013-145. Cincinnati, Ohio, USA: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH),http://www.cdc.gov/niosh/docs/2013-145/pdfs/2013-145.pdf,
  115. Savolainen K, Pylkkänen L, Norppa H, Falck G, Lindberg H, Tuomi T, Vippola M, Alenius H, Hämeri K, Koivisto J, Brouwer D, Mark D, Bard D, Berges M, Jankowska E, Posniak M, Farmer P, Singh R, Krombach F, Bihari P, Kasper G, Seipenbusch M: Nanotechnologies, engineered nanomaterials and occupational health and safety – A review. Safety Sci. 2010, 48: 957-963. 10.1016/j.ssci.2010.03.006.Google Scholar
  116. Kuempel ED, Geraci CL, Schulte PA: Risk assessment and risk management of nanomaterials in the workplace: translating research to practice. Ann Occup Hyg. 2012, 56: 491-505.Google Scholar
  117. Schulte PA, Trout DB: Nanomaterials and worker health: medical surveillance, exposure registries, and epidemiologic research. J Occup Environ Med. 2011, 53 (6 Suppl): S3-7.Google Scholar
  118. Iavicoli I, Leso V, Manno M, Schulte PA: Biomarkers of nanomaterial exposure and effect: current status. J Nanopart Res. 2014, 16: 2302-Google Scholar
  119. Engeman CD, Baumgartner L, Carr BM, Fish AM, Meyerhofer JD, Satterfield TA, Holden PA, Harthorn BH: The hierarchy of environmental health and safety practices in the U.S. nanotechnology workplace. J Occup Environ Hyg. 2013, 10: 487-495. 10.1080/15459624.2013.818231.Google Scholar
  120. Schulte PA, McKernan LT, Heidel DS, Okun AH, Dotson GS, Lentz TJ, Geraci CL, Heckel PE, Branche CM: Occupational safety and health, green chemistry, and sustainability: a review of areas of convergence. Environ Health:. 2013, 12: 31-10.1186/1476-069X-12-31.Google Scholar
  121. Eastlake A, Hodson L, Geraci CL, Crawford C: A critical evaluation of material safety data sheets (MSDS) for engineered nanomaterials. J Chem Health and Safety. 2012, 53: S108-S112.Google Scholar
  122. Schulte PA, Trout D, Zumwalde RD, Kuempel E, Geraci CL, Castranova V, Mundt DJ, Mundt KA, Halperin WE: Options for occupational health surveillance of workers potentially exposed to engineered nanoparticles: state of the science. J Occup Environ Med. 2008, 50: 517-526. 10.1097/JOM.0b013e31816515f7.Google Scholar
  123. Nasterlack M, Zober A, Oberlinner C: Considerations on occupational medical surveillance in employees handling nanoparticles. Int Arch Occup Environ Health. 2008, 81: 721-726. 10.1007/s00420-007-0245-5.Google Scholar
  124. Trout DB, Schulte PA: Medical surveillance, exposure registries, and epidemiologic research for workers exposed to nanomaterials. Toxicology. 2010, 269: 128-135. 10.1016/j.tox.2009.12.006.Google Scholar
  125. Schulte PA, Schubauer-Berigan MK, Mayweather C, Geraci CL, Zumwalde R, McKernan JL: Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. J Occup Environ Med. 2009, 51: 323-335. 10.1097/JOM.0b013e3181990c2c.Google Scholar
  126. Bostrom A, Löfstedt RE: Nanotechnology risk communication past and prologue. Risk Anal. 2010, 30: 1645-1662. 10.1111/j.1539-6924.2010.01521.x.Google Scholar
  127. United Nations Division for Sustainable development, UNDESA: A Guidebook to the Green Economy. Issue 2: Exploring Green Economy Principles. 2012, In [http://sustainabledevelopment.un.org/content/documents/743GE%20Guidebook%202%20-%20Principles_final.pdf]Google Scholar

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