Table 2 Characteristics of included studies using tests other than micronucleus and comet assay
Identifier | Nanoparticles | Animal model | Target organ | Admin. | Study design | Dose administered | Time to sacrifice | Method | Genotoxic effect reported | Summary of results |
|---|---|---|---|---|---|---|---|---|---|---|
El Mahdy [42] | mean 8.7 nm (chemical reduction – PVP stablization) | Albino rats | Liver | IP | Repeated dose | 1, 2 and 4 mg/kg bw daily for28 days | At end of study | Microscopic examination of cells in metaphase | y | Increased chromosomal aberrations, significant at 2 and 4 mg/kg bw |
Katsnelson [43] | mean 49 nm (laser ablation - naked) | Rats | Liver, bone marrow, spleen, kidney, peripheral blood & skeletal muscle | IP | Repeated dose | 10 mg/kg 3 times a week for up to 20 injections | ? | RAPD-test | y | Significantly increased evidence of DNA fragmentation in liver, bone marrow, spleen, kidney and peripheral blood cells |