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Table 4 Adjusted associations between phenols, phthalate metabolites and IQ of boys at 5 years in the EDEN cohort (N = 419 mother-son pairs, complete case analysis

From: In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years

 

Verbal IQ

 

Performance IQ

 

β

95% CI

Pvalue

Corrected

Pvaluec

β

95% CI

Pvalue

Corrected

Pvaluec

Phenols

 Parabensa

−0.060

[− 0.170; 0.050]

0.28

0.76

0.033

[−0.105; 0.171]

0.64

0.76

 2,5 dichlorophenol

0.017

[− 0.072; 0.107]

0.70

0.79

0.027

[−0.084; 0.138]

0.64

0.76

 Benzophenone-3

0.044

[−0.049; 0.138]

0.35

0.76

−0.048

[−0.164; 0.068]

0.42

0.76

 Bisphenol A

−0.032

[− 0.126; 0.063]

0.51

0.76

−0.067

[−0.184; 0.050]

0.26

0.76

 Triclosan

0.101

[0.008; 0.194]

0.03

0.76

0.007

[−0.111; 0.125]

0.91

0.91

Phthalates

 MEP

−0.039

[−0.140; 0.062]

0.45

0.76

0.012

[−0.113; 0.137]

0.85

0.88

 MBP

−0.103

[−0.244; 0.037]

0.15

0.76

−0.096

[−0.271; 0.078]

0.28

0.76

 MIBP

0.046

[−0.060; 0.152]

0.40

0.76

0.035

[−0.096; 0.166]

0.60

0.76

 MCPP

0.109

[−0.024; 0.243]

0.11

0.76

0.058

[−0.107; 0.223]

0.49

0.76

 MBZP

0.028

[−0.078; 0.133]

0.61

0.76

0.112

[−0.018; 0.242]

0.09

0.76

 MCOP

−0.062

[−0.170; 0.045]

0.26

0.76

−0.022

[−0.155; 0.111]

0.74

0.81

 MCNP

0.027

[−0.077; 0.131]

0.61

0.76

0.062

[−0.068; 0.191]

0.35

0.76

 DEHPb

−0.070

[−0.174; 0.033]

0.18

0.76

−0.062

[−0.191; 0.066]

0.34

0.76

  1. Model fit indices; RMSEA = 0.049(95% CI = 0.043–0.054), CFI = 0.930, TFI = 0.920
  2. Abbreviations: CI confidence interval, MBP mono-n-butyl phthalate, MBZP monobenzyl phthalate, MCNP monocarboxy-isononyl phthalate, MCOP monocarboxy-isooctyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEP monoethyl phthalate, MIBP mono-isobutyl phthalate
  3. aLatent variable of methyl, ethyl, propyl and butyl parabens
  4. bLatent variable of di(2-ethylhexyl) phthalate metabolites: Mono(2-ethyl-5-carboxypentyl) phthalate, Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-ethyl-5-oxohexyl) phthalate and Mono(2-ethylhexyl) phthalate
  5. cP-values corrected for multiple comparisons using the Benjamini and Hochberg false discovery rate method. β = change in IQ SD associated with 1-SD increase in ln-transformed concentrations
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Environmental Health

ISSN: 1476-069X