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Table 4 Adjusted associations between phenols, phthalate metabolites and IQ of boys at 5 years in the EDEN cohort (N = 419 mother-son pairs, complete case analysis

From: In-utero exposure to phenols and phthalates and the intelligence quotient of boys at 5 years

  Verbal IQ   Performance IQ  
β 95% CI Pvalue Corrected Pvaluec β 95% CI Pvalue Corrected Pvaluec
Phenols
 Parabensa −0.060 [− 0.170; 0.050] 0.28 0.76 0.033 [−0.105; 0.171] 0.64 0.76
 2,5 dichlorophenol 0.017 [− 0.072; 0.107] 0.70 0.79 0.027 [−0.084; 0.138] 0.64 0.76
 Benzophenone-3 0.044 [−0.049; 0.138] 0.35 0.76 −0.048 [−0.164; 0.068] 0.42 0.76
 Bisphenol A −0.032 [− 0.126; 0.063] 0.51 0.76 −0.067 [−0.184; 0.050] 0.26 0.76
 Triclosan 0.101 [0.008; 0.194] 0.03 0.76 0.007 [−0.111; 0.125] 0.91 0.91
Phthalates
 MEP −0.039 [−0.140; 0.062] 0.45 0.76 0.012 [−0.113; 0.137] 0.85 0.88
 MBP −0.103 [−0.244; 0.037] 0.15 0.76 −0.096 [−0.271; 0.078] 0.28 0.76
 MIBP 0.046 [−0.060; 0.152] 0.40 0.76 0.035 [−0.096; 0.166] 0.60 0.76
 MCPP 0.109 [−0.024; 0.243] 0.11 0.76 0.058 [−0.107; 0.223] 0.49 0.76
 MBZP 0.028 [−0.078; 0.133] 0.61 0.76 0.112 [−0.018; 0.242] 0.09 0.76
 MCOP −0.062 [−0.170; 0.045] 0.26 0.76 −0.022 [−0.155; 0.111] 0.74 0.81
 MCNP 0.027 [−0.077; 0.131] 0.61 0.76 0.062 [−0.068; 0.191] 0.35 0.76
 DEHPb −0.070 [−0.174; 0.033] 0.18 0.76 −0.062 [−0.191; 0.066] 0.34 0.76
  1. Model fit indices; RMSEA = 0.049(95% CI = 0.043–0.054), CFI = 0.930, TFI = 0.920
  2. Abbreviations: CI confidence interval, MBP mono-n-butyl phthalate, MBZP monobenzyl phthalate, MCNP monocarboxy-isononyl phthalate, MCOP monocarboxy-isooctyl phthalate, MCPP mono(3-carboxypropyl) phthalate, MEP monoethyl phthalate, MIBP mono-isobutyl phthalate
  3. aLatent variable of methyl, ethyl, propyl and butyl parabens
  4. bLatent variable of di(2-ethylhexyl) phthalate metabolites: Mono(2-ethyl-5-carboxypentyl) phthalate, Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-ethyl-5-oxohexyl) phthalate and Mono(2-ethylhexyl) phthalate
  5. cP-values corrected for multiple comparisons using the Benjamini and Hochberg false discovery rate method. β = change in IQ SD associated with 1-SD increase in ln-transformed concentrations