Health Canada. Fifth Report on Human Biomonitoring of Environmental Chemicals in Canada [Internet]. 2019. Available from: https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/environmental-contaminants/fifth-report-human-biomonitoring.html. Cited 17 Mar 2021.
Google Scholar
Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, et al. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag [Internet]. Wiley-Blackwell. 2011;7:513–41 Available from: (http://www.ncbi.nlm.nih.gov/pubmed/21793199). Cited 11 Jan 2019.
CAS
Google Scholar
Trudel D, Horowitz L, Wormuth M, Scheringer M, Cousins IT, Hungerbühler K. Estimating Consumer Exposure to PFOS and PFOA. Risk Anal [Internet]. 2008;28:251–69. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/18419647). Cited 11 Jan 2019.
Article
Google Scholar
Kannan K, Corsolini S, Falandysz J, Fillmann G, Kumar KS, Loganathan BG, et al. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environ Sci Technol [Internet]. American Chemical Society. 2004;38:4489–95. Available from: https://doi.org/10.1021/es0493446. Cited 10 May 2019.
Article
CAS
Google Scholar
Kato K, Wong L-Y, Jia LT, Kuklenyik Z, Calafat AM. Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999–2008. Environ Sci Technol [Internet]. 2011;45:8037–45. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/21469664). Cited 10 May 2019.
Article
CAS
Google Scholar
Glynn A, Berger U, Bignert A, Ullah S, Aune M, Lignell S, et al. Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden: Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996–2010. Environ Sci Technol [Internet]. 2012;46:9071–9. Available from: https://doi.org/10.1021/es301168c American Chemical Society. Cited 10 May 2019
Article
CAS
Google Scholar
Haines DA, Saravanabhavan G, Werry K, Khoury C. An overview of human biomonitoring of environmental chemicals in the Canadian Health Measures Survey: 2007–2019. Int J Hyg Environ Health [Internet]. 2017;220:13–28. Available from: (http://www.sciencedirect.com/science/article/pii/S1438463916300888).
Article
CAS
Google Scholar
Kärrman A, Mueller JF, van Bavel B, Harden F. Toms L-ML, Lindström G, Levels of 12 perfluorinated chemicals in pooled australian serum, collected 2002–2003, in relation to age, gender, and region. Environ Sci Technol [Internet]. 2006;40:3742–8. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/16830536). Cited 10 May 2019.
Article
CAS
Google Scholar
Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL, et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. National Institute of Environmental Health Science. Environ Health Perspect [Internet]. 2007;115:1298–305. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/17805419). Cited 2 Jan 2019.
Article
CAS
Google Scholar
Haines DA, Khoury C, Saravanabhavan G, Werry K, Walker M, Malowany M. Human biomonitoring reference values derived for persistent organic pollutants in blood plasma from the Canadian Health Measures Survey 2007–2011 Urban & Fischer. Int J Hyg Environ Health [Internet]. 2017;220:744–56. Available from: (https://www.sciencedirect.com/science/article/pii/S143846391630476X). Cited 4 Jan 2019.
Article
CAS
Google Scholar
Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Nang C, et al. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research [Internet]. Wiley Blackwell. Environ Toxicol Chem. 2021;40:606–30. Available from: (https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4890). Cited 17 Jun 2021.
Article
CAS
Google Scholar
Costello E, Rock S, Stratakis N, Eckel SP, Walker DI, Valvi D, et al. Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis. Environ Health Perspect [Internet]. 2022;130:46001. Available from: (https://ehp.niehs.nih.gov/doi/10.1289/EHP10092). Cited 3 May 2022.
Article
CAS
Google Scholar
Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, et al. Mechanisms of Environmental Contributions to Fatty Liver Disease. NIH Public Access. Curr Environ Heal reports [Internet]. 2019;6:80 Available from: /pmc/articles/PMC6698418/. Cited 17 Dec 2021.
Article
CAS
Google Scholar
Wolf CJ, Takacs ML, Schmid JE, Lau C, Abbott BD. Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol Sci [Internet]. 2008;106:162–71. Available from: (https://pubmed.ncbi.nlm.nih.gov/18713766/). Cited 29 June 2021.
Article
CAS
Google Scholar
Pratt DS, Kaplan MM. Evaluation of Abnormal Liver-Enzyme Results in Asymptomatic Patients. Massachusetts Medical Society. N Engl J Med [Internet]. 2000;342:1266–71. Available from: (https://www.nejm.org/doi/10.1056/NEJM200004273421707). Cited 17 June 2021.
Article
CAS
Google Scholar
Targher G, Byrne CD. Circulating Markers of Liver Function and Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol [Internet]. Lippincott Williams and Wilkins. 2015;35:2290–6. Available from: (http://atvb.ahajournals.org/site/misc/). Cited 16 June 2021.
CAS
Google Scholar
Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA. Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: Analysis of the British Women’s Heart and Health study and meta-analysis Lippincott Williams & Wilkins. Arterioscler Thromb Vasc Biol [Internet]. 2007;27:2729–35. Available from: (http://ahajournals.org). Cited 16 June 2021.
Article
CAS
Google Scholar
Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA. Alanine aminotransferase, γ-glutamyltransferase, and incident diabetes. Diabetes Care [Internet]. Diabetes Care. 2009;32:741–50. Available from: (https://pubmed.ncbi.nlm.nih.gov/19131466/). Cited 16 June 2021.
Article
CAS
Google Scholar
Liu C, Gu Y, Wang H, Fang N. Gamma-Glutamyltransferase Level and Risk of Hypertension: A Systematic Review and Meta-Analysis. Public Library of Science. PLoS One [Internet]. 2012;7:e48878 Available from: /pmc/articles/PMC3492247/. Cited 16 June 2021.
Article
CAS
Google Scholar
Liu C, Zhou W, Fang N. Gamma-glutamyltransferase levels and risk of metabolic syndrome: A meta-analysis of prospective cohort studies. Int J Clin Pract [Internet]. 2012;66:692–8. Available from: (https://pubmed.ncbi.nlm.nih.gov/22698421/). Cited 16 June 2021.
Article
CAS
Google Scholar
Kunutsor SK, Apekey TA, Seddoh D, Walley J. Liver enzymes and risk of all-cause mortality in general populations: A systematic review and meta-analysis. Oxford University Press. Int J Epidemiol. 2014;43:187–201. Available from: (https://academic.oup.com/ije/article/43/1/187/731274). Cited 16 June 2021.
Article
Google Scholar
Gallo V, Leonardi G, Genser B, Lopez-Espinosa MJ, Frisbee SJ, Karlsson L, et al. Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure. Public Health Services, US Dept of Health and Human Services. Environ Health Perspect. 2012;120:655–60.
Article
CAS
Google Scholar
Darrow LA, Groth AC, Winquist A, Shin HM, Bartell SM, Steenland K. Modeled perfluorooctanoic acid (PFOA) exposure and liver function in a Mid-Ohio Valley community. Public Health Services, US Dept of Health and Human Services. Environ Health Perspect. 2016;124:1227–33.
Article
CAS
Google Scholar
Nian M, Li QQ, Bloom M, Qian Z (Min), Syberg KM, Vaughn MG, et al. Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China. Academic Press Inc. Environ Res [Internet]. 2019;172:81–8. Available from: (https://pubmed.ncbi.nlm.nih.gov/30776734/). Cited 18 June 2021.
Article
CAS
Google Scholar
Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, et al. Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults. Nature Publishing Group. Am J Gastroenterol [Internet]. 2010;105:1354–63. Available from: https://doi.org/10.1038/ajg.2009.707.
Article
CAS
Google Scholar
Attanasio R. Sex differences in the association between perfluoroalkyl acids and liver function in US adolescents: Analyses of NHANES 2013-2016. Elsevier Ltd. Environ Pollut. 2019;254:113061.
Article
CAS
Google Scholar
Jain RB, Ducatman A. Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances with Liver Function Biomarkers: NHANES 2011 to 2014 Data on US Adults Aged ≥20 Years. J Occup Environ Med. 2019;61:293–302.
Article
CAS
Google Scholar
Gleason JA, Post GB, Fagliano JA. Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007–2010. Environ Res Academic Press Inc. Environ Res. 2015;136:8–14.
Article
CAS
Google Scholar
Cakmak S, Lukina A, Karthikeyan S, Atlas E, Dales R. The association between blood PFAS concentrations and clinical biochemical measures of organ function in participants of the Canadian Health Measures Survey (CHMS). Sci Total Environ. 2022;827:153900.
Article
CAS
Google Scholar
Stratakis N, Conti DV, Jin R, Margetaki K, Valvi D, Siskos AP, et al. Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children John Wiley & Sons, Ltd. Hepatology [Internet]. 2020;72:1758–70. Available from: (https://onlinelibrary.wiley.com/doi/full/10.1002/hep.31483). Cited 30 June 2022.
Article
CAS
Google Scholar
Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity Netw Open. JAMA Netw Open [Internet]. 2018;1:e181493. Available from: (https://pubmed.ncbi.nlm.nih.gov/30646133/). Cited 16 Nov 2021.
Article
Google Scholar
Cardenas A, Hivert MF, Gold DR, Hauser R, Kleinman KP, Lin PID, et al. Associations of perfluoroalkyl and polyfluoroalkyl substances with incident diabetes and microvascular disease. American Diabetes Association Inc. Diabetes Care [Internet]. 2019;42:1824–32 Available from: /pmc/articles/PMC6702604/. Cited 17 Nov 2021.
Article
CAS
Google Scholar
Lin PID, Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, et al. Per- and polyfluoroalkyl substances and blood lipid levels in pre-diabetic adults-longitudinal analysis of the diabetes prevention program outcomes study. Environ Int [Internet]. 2019;129:343–53. Available from: (https://pubmed.ncbi.nlm.nih.gov/31150976/). Cited 17 Nov 2021.
Article
CAS
Google Scholar
Tremblay M, Wolfson M, Gorber SC. Canadian Health Measures Survey: rationale, background and overview. Health Rep. 2007;18(Suppl):7–20.
Google Scholar
Giroux S. Canadian Health Measures Survey: sampling strategy overview. Heal reports [Internet]. 2007;18:31–6. Available from: (https://pubmed.ncbi.nlm.nih.gov/18210868/). Cited 29 June 2021.
Google Scholar
Day B, Langlois R, Tremblay M, Knoppers B-M. Canadian Health Measures Survey: Ethical, legal and social issues. Heal Rep [Internet]. 2007;18(suppl):37–51. Available from: (https://www150.statcan.gc.ca/n1/pub/82-003-s/2007000/article/10364-eng.pdf). Cited 5 Jan 2022.
Google Scholar
Statistics Canada. Canadian Health Measures Survey (CHMS) Data User Guide: Cycle 5. Available upon request: STATCAN.infostats-infostats.STATCAN@canada.ca. 2020.
Health Canada. Second Report on Human Biomonitoring of Environmental Chemicals in Canada. [Internet]. Ottawa, ON; 2013. Available from: https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/ewh-semt/alt_formats/pdf/pubs/contaminants/chms-ecms-cycle2/chms-ecms-cycle2-eng.pdf Cited 3 May 2019
Health Canada. Report on Human Biomonitoring of Environmental Chemicals in Canada. [Internet]. 2010. Available from: https://www.canada.ca/en/health-canada/services/environmental-workplace-health/reports-publications/environmental-contaminants/8-results-chemical-group-report-human-biomonitoring-environmental-chemicals-canada-health-canada-2010.html#n8_5. Cited 15 Jan 2019.
Google Scholar
Adeli K, Higgins V, Nieuwesteeg M, Raizman JE, Chen Y, Wong SL, et al. Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey. Oxford Academic. Clin Chem [Internet]. 2015;61:1049–62. Available from: (https://academic.oup.com/clinchem/article/61/8/1049/5611534). Cited 17 Nov 2021.
Article
CAS
Google Scholar
Statistics Canada. Table 13–10–0373–01 Overweight and obesity based on measured body mass index, by age group and sex. 2021.
Google Scholar
Colley RC, Gorber SC, Tremblay MS. Quality control and data reduction procedures for accelerometry-derived measures of physical activity. Heal Reports [Internet]. 2010;21:63–9. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/20426228).
Google Scholar
Colley RC, Tremblay MS. Moderate and vigorous physical activity intensity cut-points for the Actical accelerometer. J Sports Sci [Internet]. 2011;29:783–9. Available from: (http://www.tandfonline.com/doi/abs/10.1080/02640414.2011.557744).
Article
Google Scholar
Janssen I, Katzmarzyk PT, Ross R. Waist circumference and not body mass index explains obesity-related health risk. Am J Clin Nutr [Internet]. 2004;79:379–84. Available from: (https://pubmed.ncbi.nlm.nih.gov/14985210/). Cited 6 Jul 2022.
Article
CAS
Google Scholar
Statistics Canada. Instructions for Combining Multiple Cycles of Canadian Health Measures Survey (CHMS) Data. Available upon request: STATCAN.infostats-infostats.STATCAN@canada.ca. 2017.
Desquilbet L, Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. John Wiley & Sons, Ltd. Stat Med [Internet]. 2010;29:1037–57. Available from: (http://doi.wiley.com/10.1002/sim.3841). Cited 7 Aug 2019.
Google Scholar
Ross R, Chaput J-P, Giangregorio LM, Janssen I, Saunders TJ, Kho ME, et al. Canadian 24-Hour Movement Guidelines for Adults aged 18–64 years and Adults aged 65 years or older: an integration of physical activity, sedentary behaviour, and sleep1. https://doi.org/101139/apnm-2020-0467 [Internet]. NRC Research Press 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7. Appl Physiol Nutr Metab. 2020;45:S57-102. Available from: (https://cdnsciencepub.com/doi/abs/10.1139/apnm-2020-0467). Cited 22 Sep 2021.
Article
Google Scholar
Keil AP, Buckley JP, O’Brien KM, Ferguson KK, Zhao S, White AJ. A quantile-based g-computation approach to addressing the effects of exposure mixtures. Env Heal Perspect. 2019;128:1–10.
Google Scholar
Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. Am J Gastroenterol [Internet]. 2017;112:18–35. Available from: (https://journals.lww.com/ajg/Fulltext/2017/01000/ACG_Clinical_Guideline__Evaluation_of_Abnormal.13.aspx). Cited 30 June 2022.
Article
CAS
Google Scholar
Hall P, Cash J. What is the Real Function of the Liver ‘Function’ Tests? Ulster Medical Society. Ulster Med J [Internet]. 2012;81:30 /pmc/articles/PMC3609680/.
Google Scholar
Sen P, Qadri S, Luukkonen PK, Ragnarsdottir O, McGlinchey A, Jäntti S, et al. Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. J Hepatol [Internet]. 2022;76(2):283–93. Elsevier B.V.; 2021;0. Available from: http://www.journal-of-hepatology.eu/article/S0168827821021048/fulltext. Cited 17 Dec 2021
Oh RC, Hustead TR, Ali SM, Pantsari MW. Mildly Elevated Liver Transaminase Levels: Causes and Evaluation. Am Fam Physician. 2017;96:709–15.
Google Scholar
Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, et al. Environmental Perfluoroalkyl Acid Exposures Are Associated with Liver Disease characterized by Apoptosis and Altered Serum Adipocytokines NIH Public Access. Environ Pollut [Internet]. 2019;247:1055 Available from: /pmc/articles/PMC6404528/. Cited 17 Dec 2021.
Article
CAS
Google Scholar
Borghese MM, Tremblay MS, LeBlanc AG, Leduc G, Boyer C, Chaput JP. Comparison of ActiGraph GT3X+ and Actical accelerometer data in 9–11-year-old Canadian children. J Sports Sci [Internet]. 2017;35:517–24. Available from: (http://www.ncbi.nlm.nih.gov/pubmed/27103499).
CAS
Google Scholar
Le Magueresse-Battistoni B. Endocrine disrupting chemicals and metabolic disorders in the liver: What if we also looked at the female side? [Internet]. Chemosphere. Elsevier Ltd; 2021;268:129212. Available from: https://pubmed.ncbi.nlm.nih.gov/33359838/. cited 2021 Jan 6
Mamsen LS, Björvang RD, Mucs D, Vinnars M-T, Papadogiannakis N, Lindh CH, et al. Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies Pergamon. Environ Int [Internet]. 2019;124:482–92. Available from: (https://www.sciencedirect.com/science/article/pii/S0160412018326102?via%3Dihub). Cited 24 Jun 2019.
Article
CAS
Google Scholar
Lakind JS, Verner MA, Rogers RD, Goeden H, Naiman DQ, Marchitti SA, et al. Current Breast Milk PFAS Levels in the United States and Canada: After All This Time, Why Don’t We Know More? Environ Health Perspect [Internet]. Environmental Health Perspectives. 2022;130(2). Available from: https://ehp.niehs.nih.gov/doi/full/10.1289/EHP10359. Cited 30 Jun 2022
Ding N, Harlow SD, Batterman S, Mukherjee B, Park SK. Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women’s Health Across the Nation. Elsevier Ltd. Environ Int. 2020;135:105381.
Article
CAS
Google Scholar
Wong F, MacLeod M, Mueller JF, Cousins IT. Enhanced elimination of perfluorooctane sulfonic acid by menstruating women: Evidence from population-based pharmacokinetic modeling. Environ Sci Technol [Internet]. American Chemical Society. 2014;48:8807–14. Available from: (https://pubs.acs.org/sharingguidelines). Cited 29 Mar 2021.
CAS
Google Scholar
Fabbrini E, Sullivan S, Klein S. Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic and Clinical Implications NIH Public Access. Hepatology [Internet]. 2010;51:679 Available from: /pmc/articles/PMC3575093/. Cited 5 Jan 2022.
Article
CAS
Google Scholar
Ali N, Sumon AH, Fariha KA, Asaduzzaman M, Kathak RR, Molla NH, et al. Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population Nature Publishing Group. Sci Rep [Internet]. 2021;11:6640 Available from: /pmc/articles/PMC7988042/. Cited 30 Jun 2022.
Article
CAS
Google Scholar
Khan AR, Awan FR, Najam SS, Islam M, Siddique T, Zain M. Elevated serum level of human alkaline phosphatase in obesity - PubMed. J Pak Med Assoc [Internet]. 2015;65:1182–5. Available from: (https://pubmed.ncbi.nlm.nih.gov/26564289/). Cited 30 Jun 2022.
Google Scholar
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for perfluoroalkyls [Internet]. Atlanta, Georgia; 2021. Available from: https://stacks.cdc.gov/view/cdc/59198