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Table 1 Demographics and tumor characteristics according to the geographical area of residency

From: Per- and polyfluoroalkyl substances (PFAS) exposure in melanoma patients: a retrospective study on prognosis and histological features

 

Exposed cohort (n = 194)

Unexposed cohort (n = 488)

p-value

Age, years a

50 (37–62)

49 (38–61)

0.90

Males

96 (49.5)

227 (46.5)

0.54

Primary site:

 Acral

12 (6.2)

28 (5.7)

0.93

 Head/neck

18 (9.3)

40 (8.2)

 Upper limb

43 (22.2)

120 (24.6)

 Trunk

92 (47.4)

235 (48.2)

 Lower limb

29 (14.9)

65 (13.3)

 Breslow thickness, mm ab

0.9 (0.5–2.0)

0.8 (0.4–1.8)

0.23

Ulceration: c

 Absent

144 (76.6)

372 (79.3)

0.51

 Present

44 (23.4)

97 (20.7)

 Presence of Mitoses d

134 (70.5)

284 (58.7)

0.005

pTNM:

 I

116 (59.8)

325 (66.6)

0.22

 II

43 (22.2)

85 (17.4)

 III

35 (18.0)

78 /16.0)

Subtype: e

 ALM

4 (2.0)

14 (3.0)

0.78

 LMM

5 (2.7)

7 (1.5)

 NM

33 (17.6)

85 (18.1)

 SSM

141 (75.0)

347 (73.8)

 Other f

5 (2.7)

17 (3.6)

  1. Data expressed as n (%) or a median (IQR). Data not available in b32, c25, d8 and e24 patients. fOther subtypes included desmoplastic (4 patients), neurotropic (1 patient), nevoid (8 patients), pagetoid (1 patient), polypoid (2 patients) and spitzoid (6 patients). ALM Acral Lentiginous Melanoma, LMM Lentigo Maligna Melanoma, NM Nodular Melanoma, SSM Superficial Spreading Melanoma