Polanczyk G, De Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164:942–8.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
Visser SN, Danielson ML, Bitsko RH, Holbrook JR, Kogan MD, Ghandour RM, et al. Trends in the parent-report of health care provider-diagnosed and medication Attention Deficit/Hyperactivity Disorder: United States, 2003–2011. J Am Acad Child Adolesc Psychiatry. 2013. [In Press]. [http://www.cdc.gov/ncbddd/adhd/prevalence.html].
Banjeree TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Pediatrica. 2007;96:1269–74.
Grizenko N, Fortier ME, Zadorozny C, Thakur G, Schmitz N, Duval R, et al. Maternal stress during pregnancy, ADHD symptomatology in children and genotype: Gene environment interaction. J Can Acad Child Adolesc Psychiatry. 2010;21:9–15.
Waldman ID, Gizer IR. The genetics of attention deficit hyperactivity disorder. Clin Psychol Rev. 2006;26:396–432.
Ericson JE, Crinella FM, Clarke-Stewart KA, Allhusen VD, Chan T, Robertson RT. Prenatal manganese levels linked to behavioural disinhibition. Neurotoxicol Teratol. 2007;29:181–7.
Walkowiak J, Wiener A, Fastabend A, Heinzow B, Krämer U, Schmidt E, et al. Environmental exposure to polychlorinated biphenyls and quality of the home environment: Effects on psychodevelopment in early childhood. Lancet. 2001;358:1602–7.
Winneke G. Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls. J Neurol Sci. 2011;308:9–15.
Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: Review of the current evidence. Am J Psychiatry. 2003;160:1028–40.
Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, et al. Cognitive deficit in 7-yr-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997;19:417–28.
Young HA, Geier DA, Geier MR. Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the Vaccine Safety Datalink. J Neurol Sci. 2008;271:110–8.
Roy A, Kordas K, Lopez P, Rosado JL, Cebrain ME, Vargas GG, et al. Association between arsenic exposure and behaviour among first graders from Torreon Mexico. Environ Res. 2011;111:670–6.
Tsai SY, Chou HY, The HW, Chen CM, Chen CJ. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology. 2003;24:747–53.
Nigg JT, Lewis K, Edinger T, Falk M. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012;51:86–97.
Kuehn BM. Increased risk of ADHD associated with early exposure to pesticides, PCBs. JAMA. 2010;304:27–8.
Nigg JT, Knottnerus MG, Martel MM, Nicholas M, Cavanagh K, Karmaus W, et al. Low blood lead levels associated with clinically diagnosed attention deficit/hyperactivity disorder and mediated by weak cognitive control. J Biol Psychiatry. 2008;63:325–31.
Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental neurotoxicity. Lancet Neurol. 2014;13:330–8.
National research council. Fluoride in drinking water: a scientific review of EPA standards. Committee on fluoride in drinking water, board on environmental studies and toxicology, division on earth and life sciences. Washington, D.C.: The National Academies Press; 2006.
Centers for Disease Control and Prevention. Water fluoridation statistics. 2012. Retrieved March 12, 2015 from [http://www.cdc.gov/fluoridation/statistics/2012stats.htm].
Department of Health and Human Services (U.S. DHHS). Fluoridation Census. Department of Health and Human Services, USA. 1993.
Centers for Disease Control and Prevention. Community Water Fluoridation Frequently Asked Questions. 2013. Retrieved November 3, 2013 from [http://www.cdc.gov/fluoridation/faqs/].
Department of Health and Human Services. (U.S. DHHS). Review of Fluoride: Benefits and Risks. Report of the Ad Hoc Committee on Fluoride, Committee to Coordinate Environmental Health and Related Programs. USA: Department of Health and Human Services; 1991 [http://www.dentalwatch.org/fl/phs_1991.pdf].
ED B -A, Barker L, Dye BA. Prevalence and Severity of Dental Fluorosis in the United States, 1999–2004, NCHS Data Brief No. 53. Figure 3. 2010.
Department of Health and Human Services (U.S. DHHS). Proposed HHS Recommendation for Fluoride Concentration in Drinking Water for Prevention of Dental Carries: A notice from the Health and Human Services Department. Fed Regist. 2011. [https://www.federalregister.gov/articles/2011/01/13/2011-637/proposed-hhs-recommendation-for-fluoride-concentration-in-drinking-water-for-prevention-of-dental].
Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ. Neurotoxicity of sodium fluoride in rats. Neurotoxicol Teratol. 1995;17:169–77.
Sawan RM, Leite GA, Saraiva MC, Barbosa Jr F, Tanus-Santos JE, Gerlach RF. Fluoride increases lead concentrations in whole blood and in calcified tissues from lead-exposed rats. Toxicology. 2010;271:21–6.
Liu YJ, Gao Q, Wu CX, Guan ZZ. Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory. Toxicol Lett. 2010;192:324–9.
Zhu Y, Zheng Y, Ma Y, Zhang J. Effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats. J Xinjiang Med Univ. 2012.
Baily CDC, De Biasi M, Fletcher PJ, Lambe EK. The nicotinic acetylcholine receptor α5 subunit plays a key role in attention circuitry and accuracy. J Neurosci. 2010;30:9241–52.
Chen J, Shan KR, Wang YN, Nordberg A, Guan ZZ. Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride. Toxicology. 2003;183:235–42.
Heilbronn E. Action of fluoride on cholinesterase I. On the mechanism of inhibition. Acta Chemcia Scandinavica. 1965;19:1333.
Zhai JX, Guo ZY, Hu CL, Wang QN, Zhu QX. Studies on fluoride concentration and cholinesterase activity in rat hippocampus. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003;21:102–4.
Levin ED, Bushnell PJ, Rezvani AH. Attention modulating effects of cognitive enhancers. Pharmacol Biochem Behav. 2011;99:146–54.
Long YG, Wang Y, Chen J, Jiang S, Nordberg A. Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain. Neurotoxicol Teratol. 2002;24:751–7.
Lee J, Laurin N, Crosbie J, Ickowicz A, Pathare T, Malone M, et al. Association study of the nicotinic acetylcholine receptor α4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Genes Brain Behav. 2008;7:53–60.
Todd RD, Lobos EA, Sun LW, Neuman RJ. Mutational Analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention/hyperactivity disorder. Evidence for association of an intronic polymorphism with attention problems. Mol Psychiatry. 2003;8:103–8.
Grottick AJ, Higgins GA. Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res. 2000;117:197–208.
Levin ED, Conners CK, Silva D, Canu W, March J. Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder. Exp Clin Psychopharmacol. 2001;9:83–90.
Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, Levin ED. Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:269–75.
Rezvani AH, Cauley M, Sexton H, Xiao Y, Brown ML, Paige MA, et al. Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague–Dawley rats. Psychopharmacology (Berl). 2011;215:621–30.
Dong Z, Wan C, Zhang X, Liu J. Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area. J Guiyang Med Coll. 1993;18:241–5.
Yu Y, Yang W, Dong Z, Wan C, Zhang J, Liu J, et al. Neurotransmitter and receptor changes in the brains of fetuses from areas of endemic fluorosis. Translated research report. Fluoride. 2008;41:134–8.
Forestier F, Daffos F, Said R, Brunet CM, Guillaumo PN. The passage of fluoride across the placenta. An intra-uterine study. J Obstet Gynecol Reprod Biol. 1990;19:171–5.
Malhotra A, Tewari A, Chawla HS, Gauba K, Dhall K. Placental transfer of fluoride in pregnant women consuming optimum fluoride in drinking water. J Indian Soc Pedod Prev Dent. 1993;11:1–3.
Li J, Yao L, Shao Q-L. Effects of high-fluoride on neonatal neurobehavioural development. Chin J Endemiol. 2004;23:464–5.
Calderón J, Machado B, Navarro M, Carrizales L, Ortiz MD, Diaz-Barriga F. Influence of fluoride exposure on reaction time and visuospatial organization in children [Abstract]. Epidemiology. 2000;11:s153.
Rocha-Amador D, Navarro M, Trejo-Acevedo A, Carrizales L, Perez-Maldonado F, Díaz-Barriga F, et al. Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children. Neurotoxicology. 2009;30:1149–54.
Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 2012;120:1362–8.
Hong F, Cao Y, Yang D, Wang H. A study of fluorine effects on children’s intelligence development under different environments. Chin Prim Health Care. 2001;15:56–7.
Li XS, Zhi JL, Gao RO. Effect of fluoride exposure on intelligence in children. Fluoride. 1995;28:189–92.
Poureslami HR, Horri A, Atash R. High fluoride exposure in drinking water: effect on children’s IQ, one new report. Int J Pediatric Dent. 2011;21 Suppl 1:47.
Seraj B, Shahrabi M, Falahzade M, Falahzade FP, Akhondi N. Effect of high fluoride concentration in drinking water on children’s intelligence. J Dental Med. 2006;19:80–6.
Wang SH, Wang LF, Hu PY, Guo SW, Law SH. Effects of high iodine and high fluorine on children’s intelligence and thyroid function. Chin J Endemiol. 2001;20:288–90.
Xu YL, Lu CS, Zhang XN. Effect of fluoride on children’s intelligence. Endem Dis Bull. 1994;2:83–4.
Yao LM, Deng Y, Yang SY, Zhou JL, Wang SL, Cui JW. Comparison of children’s health and intelligence between the fluorosis areas with and without altering water sources. Lit Inf Prev Med. 1997;3:42–3.
Lin F, Ai HT, Zhao HX, Lin J, Jhiang JY, Maimaiti A. The relationship of a low-iodine and high-fluoride environment to subclinical cretinism in Xinjiang. Endem Dis Bull. 1991;6:62–7.
Ding Y, Yanhuigao Sun H, Han H, Wang W, Ji X, Liu X, et al. The relation between low levels of urine fluoride on children’s intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. J Hazard Mater. 2011;186:1942–6.
The National Survey of Children’s Health. [http://www.cdc.gov/ncbddd/adhd/prevalence.html].
U.S. Census Bureau, Population Division. State Population Estimates: Annual Time Series, July 1, 1990 to July 1, 1999. 1999. Retrieved November 3, 2013 from [http://www.census.gov/popest/data/historical/index.html].
U.S. Census Bureau, Population Division. Table 1: Annual Estimates of the Resident Population for the United States, Regions, States, and Puerto Rico: April 1, 2000 to July 1, 2008. 2008. Retrieved November 3, 2013 from [http://www.census.gov/popest/data/historical/index.html].
U.S. Department of Commerce. Census Regions and Divisions of the United States. U.S. Census Bureau. 2013. [http://www.census.gov/geo/maps-data/maps/pdfs/reference/us_regdiv.pdf].
Burt BA. Fluoridation and social equality. J Public Health Dent. 2002;62:195–200.
Burt BA. Concepts of risk in dental public health. Community Dent Oral Epidemiol. 2005;33:240–7.
U.S. Census Bureau. Table H-8: Median Household Income by State: 1984 to 2012. 2013 [https://www.census.gov/hhes/www/income/data/historical/household/].
Maas RP, Patch SC, Christian AM, Coplan MJ. Effects of fluoridation and disinfection agent combinations on lead leaching from leaded-brass parts. Neurotoxicology. 2007;28:1023–31.
Coplan MJ, Patch SC, Masters RD, Bachman MS. Confirmation of and explanations for elevated blood lead and other disorders in children exposed to water disinfection and fluoridation chemicals. Neurotoxicology. 2007;28:1032–42.
Macek M, Matte TD, Sinks T, Malvitz DM. Blood lead concentrations in children and method of water fluoridation in the United States, 1988–1994. Environ Health Perspect. 2006;114:130–4.
Masters RD, Coplan M. Water treatment with Silicofluorides and Lead Toxicity. Int J Environ Stud. 1999;56:435–49.
Masters RD, Coplan MJ, Hone BT, Dykes JE. Association of silicofluoride treated water with elevated blood lead. Neurotoxicology. 2000;21:1091–9.
Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and ADHD in U.S. Children. Environ Health Perspect. 2006;114:1904–9.
Froehlich TE, Lanphear BP, Auinger P, Hornung R, Epstein JN, Braun J, et al. Association of tobacco and lead exposures with ADHD. Pediatrics. 2009;124:1053–63.
Galletti P, Joyet G. Effect of fluorine on thyroidal iodine metabolism in hyperthyroidism. J Clin Endocrinol. 1958;18:1102–10.
Klein RZ, Sargent JD, Larsen PR, Waisbren SE, Haddow JE, Mitchell ML. Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen. 2001;8:18–20.
Merck & Co., Inc. The Merck index: an encyclopedia of chemicals and drugs, 8th Edition, Rahway, New Jersey, U.S.A. 1968. [http://www.fluoridealert.org/wp-content/uploads/merck-1968.pdf].
Smith JW, Evans AT, Costall B, Smythe JW. Thyroid hormones, brain function and cognition: a brief review. Neurosci Biobehav Rev. 2002;26:45–60.
Vermiglio F, Lo Presti VP, Moleti M, Sidoti M, Tortorella G, Scaffidi G, et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab. 2004;89:6054–60.
De Cock M, Maas Y, Van de Bor M. Does perinatal exposure to endocrine disruptors induce autism spectrum and attention-deficit hyperactivity disorders? Review. Acta Paediatr. 2012;101:811–8.