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Carbon monoxide and risk of outpatient visits due to cause-specific diseases: a time-series study in Yichang, China

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Abstract

Background

Previous studies showed inconsistent results on risk of increased outpatient visits for cause-specific diseases associated with ambient carbon monoxide (CO).

Methods

Daily data for CO exposure and outpatient visits for all-causes and five specific diseases in Yichang, China from 1st January 2016 to 31st December 2017 were collected. Generalised additive models with different lag structures were used to examine the short-term effects of ambient CO on outpatient visits. Potential effect modifications by age, sex and season were examined.

Results

A total of 5,408,021 outpatient visits were recorded. We found positive and statistically significant associations between CO and outpatient visits for multiple outcomes and all the estimated risks increased with longer moving average lags. An increase of 1 mg/m3 of CO at lag06 (a moving average of lag0 to lag6), was associated with 24.67% (95%CI: 14.48, 34.85%), 21.79% (95%CI: 12.24, 31.35%), 39.30% (95%CI: 25.67, 52.92%), 25.83% (95%CI: 13.91, 37.74%) and 19.04% (95%CI: 8.39, 29.68%) increase in daily outpatient visits for all-cause, respiratory, cardiovascular, genitourinary and gastrointestinal diseases respectively. The associations for all disease categories except for genitourinary diseases were statistically significant and stronger in warm seasons than cool seasons.

Conclusion

Our analyses provide evidences that the CO increased the total and cause-specific outpatient visits and strengthen the rationale for further reduction of CO pollution levels in Yichang. Ambient CO exerted adverse effect on respiratory, cardiovascular, genitourinary, gastrointestinal and neuropsychiatric diseases especially in the warm seasons.

Introduction

Carbon monoxide (CO) is an air pollutant primarily from traffic or industry in most urban communities. The human exposure studies have well documented acute CO poisoning at high concentrations [1]. As for environmentally relevant CO, recent epidemiological studies have found that ambient CO has significant adverse effects on public health worldwide [2,3,4]. The population-based studies from 126 United States urban counties showed the positive effects of ambient CO on cardiovascular disease (CVD) hospital admissions [3]. An European study conducted in 6 Italian cities showed significant and positive associations between CO and emergency room visits for acute respiratory diseases (RED) [4]. However, some recent experimental and clinical studies suggested that low levels of exogenous CO may have therapeutic effects under certain circumstances [5, 6], and population-based studies in China generated similar findings that environmentally relevant CO exposure reduced risk of hospital admissions for respiratory tract infections, stroke and chronic obstructive pulmonary diseases [7,8,9]. In a study of 10 United States cities, it was also indicated that 1-ppm increase of CO was associated with a 0.7% decrease in daily mortality [10].

Furthermore, because ambient CO primarily results from traffic or industry in urban communities, risks associated with CO may be confounded or modified by other traffic-related air pollutants, such as nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3) and fine particles (particulate matter with aerodynamic diameter ≤ 10 μm [PM10] or  ≤ 2.5 μm [PM2.5]). The experimental and clinical studies can provide useful scientific evidence but typically involve exposure to CO alone [3]. The lack of co-pollutant models has contributed to the inability to disentangle the effects attributed to ambient CO from those of the larger complex air pollution mix.

Many studies have reported the association between ambient CO and cardiorespiratory diseases [11,12,13]. However, other common diseases such as neuropsychiatric (NPD), genitourinary (GUD) and gastrointestinal diseases (GID) were rarely examined. In recent years, some studies showed the associations between ambient CO and other diseases besides cardiorespiratory systems [4, 14], which may be important to consider when the policies regarding CO standards and guidelines are evaluated. Therefore, all of these together point towards a need for a comprehensive understanding of the health effects for various body systems induced by ambient CO exposure, especially at low concentrations of CO.

As the largest low- and middle-income countries, China is experiencing one of the worst air pollution problems in the world. However, in Yichang, a city located in Hubei province in central China with 4.2 million people, outdoor CO levels are low (daily average of 1.07 mg/m3) and well below the World Health Organization (WHO) guideline of 10 mg/m3. Little research has been done on the potential health effects in humans from current ambient exposure to generally low CO levels, especially in China. Research has been focused on air pollution associated mortality in China and there has been limited research on the association between air pollution and morbidity, such as outpatient visits for specific diseases mainly due to limited access to high-quality hospital data. Yichang, however, is one of only a handful of cities in China where data from all hospitals are collected in a systematic manner to a single database and therefore an ideal city for researching the effects of air pollution on outpatient visits in China.

In the current study, a time-series analysis was performed to evaluate the short effects of exposure to ambient CO on outpatient visits for total causes and RED, CVD, NPD, GUD and GID. We addressed key scientific questions about associations of CO at low levels with cause-specific outpatient categories, possible confounding by co-pollutants in the urban air pollution mixture and effects modifications for age, sex and season.

Materials and methods

Data collection

Hospital outpatient data

Health data was collected from all health organizations in Yichang, from district to city level health facilities, and stored on a cloud server which is run by Yichang Center for Disease Control and Prevention (CDC). Daily cause-specific outpatient data for eight of the largest hospitals in the city of Yichang (accounting for 96% of all outpatient visits in the city) were obtained from the Big Data Centre, covering the period from 1st January 2016 to 31st December 2017. Anonymised outpatient visits records were extracted according to age, gender, the date of visit and International Classification of Diseases, Tenth Revision (ICD-10). All of the outpatient visits were further classified by the ICD-10, for total causes: A00-Z99, CVD: I00-I99, RED: J00-J99, GUD: N00-N99, GID: K00-K93, NPD: F00-G99. For further analyses, we also divided the total causes outpatient visits to different age groups (0 ≤ age < 6, 6 ≤ age < 65 and age ≥ 65), gender groups (male and female). The whole year was divided into two seasons, warm season (April to September) and cold season (January to March and October to December), according to the seasonal characteristics of Yichang. Ethics approval and consent from individuals were not required, as only aggregated non-identifiable data were used in this study.

Air pollution and weather factors data

Data on concentration of CO, were obtained from Yichang Municipal Bureau of Environmental Protection from 1st January 2016 to 31st December 2017. The bureau was responsible for the monitor stations which provided hourly air pollution data to the Big Data Centre of Yichang CDC. The data for pollutants was an average of the daily readings from each of the 14 air quality monitoring stations. We also included measurements of PM2.5, PM10, SO2, NO2, and O3 for adjustment in multi-pollutant models. Missing data were identified for air pollutant variables for 2 days out of the two-year period. As 2 days only accounts for 0.27% of the total number of days in the study period, dates with missing values were excluded from the analysis. In addition, we got the meteorological variables contained daily (24-h) average temperature and relative humidity (RH) from the Big Data Centre in Yichang to allow for adjustment of weather factors on outpatient visits.

Statistical analysis

Outpatient visits were linked with air pollutant concentrations by date. Generalized additive models (GAM) were used to investigate the associations between daily concentrations of CO and daily counts of outpatient visits for total causes, CVD, RED, GUD, GID and NPD. Quasi-Poisson regression was used in the model because outpatient visits tended to display an over-dispersed poisson distribution. Specifically, we used 5–10 degrees of freedom (df) per year for time trend. When the df was 7, the absolute magnitude of the partial autocorrelation function was lowest, so the basic model was regarded as adequate [15] and a cubic spline function with 7 df per year was applied to calendar time to account for unmeasured long-term and seasonal trends. Cubic spline functions were also applied to current-day temperature (6 df) and humidity (3 df), to allow for adjustment of potential meteorological confounding factors [16]. Day of the week and season were also included in the basic model to adjust for the day effect on outpatient visits within a week and season effect within a year. Public holidays were introduced as a dummy variable to adjust for the holiday effects.

After we constructed the basic models, we introduced the CO variable to create a single-pollutant model to estimate the association with total causes outpatient visits, and then separately for different diseases categories. We revealed the lag effects with various lag structures—from the days of outpatient visit (lag 0) up to seven lag days (lag 7). In addition, the models included the moving averages as averages of the exposure lags to avoid underestimating the effect of pollutants measured by single-day lag models [17]. For example, the 2-day moving average (lag 01) was concentration computed as the means of lag 0 and lag 1 days.

Previous literatures [18, 19] has suggested there were effect modifications for age, gender and season when investigating the effects of air pollution on hospital visits. Therefore, additional analyses were conducted to explore the potential modifications by age, gender and season subgroups. We evaluated the statistical significance for the differences in different age groups, gender and season [14]. To examine the stability of CO on outpatient visits, multi-pollutant analyses were performed to adjust for the other pollutants included NO2, O3, SO2, PM2.5 and PM10, using the same parameter settings as in the main model. Finally, exposure-response (E-R) curves using the same models at lag 06 additionally using a spline function to model the exposure variable, were created to assess CO concentrations against cause-specific outpatient visits.

Effect estimates were described as percent changes and 95% CIs in daily outpatient visits for total causes and different diseases per 1 mg/m3 increase in CO. The statistical tests were two-sided, and P-values< 0.05 were considered statistically significant. All analyses were performed using the SAS (version 9.4; SAS Institute Inc.) and MGCV package in the R software (R 3.5.0).

Results

Table 1 summarizes descriptive statistics of this study on outpatient data, air pollutants and weather factors in Yichang from 1st January 2016 to 31st December 2017. A total of 5,408,021 cases of outpatient visits occurred over the two-year study period (731 days), with a daily mean of 7418 cases. Females and the patients between 6 and 64 years of age accounted for 58.7 and 70.4%, respectively. Outpatient visits were slightly higher in cool seasons (50.5%) than in warm seasons (49.5%). Daily concentrations of CO were low during the study period, with a daily average of 1.07 mg/m3 and a maximum of 2.63 mg/m3 in Yichang (The WHO air quality guideline for CO is 10 mg/m3). The mean of daily temperature and relative humidity were 17 °C and 77%, respectively. Table 2 shows the daily concentration of CO was moderately and positively correlated with PM10, PM2.5, NO2 and SO2 (Pearson correlation coefficient r = 0.42–0.72), and negatively correlated with O3 and temperature. The daily average of relative humidity were not correlated with CO (r < 0.1).

Table 1 Summary statistics of outpatient visits, air pollutants and meteorological factors in Yichang, China
Table 2 Pearson correlation coefficients for meteorology factors and air pollutants

Figure 1 presents the percent changes and 95% CIs of outpatient visits for total causes, RED, CVD, GUD, GID and NPD associated with 1 mg/m3 increments in CO at different single lags and moving average lag days. The analyzed outpatient categories for total, RED, CVD, GUD and GID, with the exception of NPD, were statistically significant and positively associated with the most of the lag periods concentrations of ambient CO, while NPD showed the only statistically significant association at lag 5. The associations were not statistically significant for all outcomes at lag 7. For moving averages lag days from lag 01 to lag 06, the associations for all of the outpatient categories except NPD were statistically significant and positive, and all the estimated risks increased as the average of longer lags were considered. The percent increases were strongest at lag 06 days for all outpatient categories, and a 1-mg/m3 increase in concentration of CO was associated with increments of 24.67% (14.48, 34.85%), 21.79% (12.24, 31.35%), 39.30% (25.67, 52.92%), 25.83% (13.91, 37.74%), 19.04% (8.39, 29.68%) in daily outpatient visits for total causes, RED, CVD, GUD and GID, respectively.

Fig. 1
figure1

Percent changes of cause-specific outpatient visits associated with 1 mg/m3 increments in CO. Abbreviation: RED respiratory diseases, CVD cardiovascular diseases, GUD genitourinary diseases, GID gastrointestinal diseases, NPD neuropsychiatric diseases. Note: The X-axis is the lag days from lag0 to lag7 (a), and the moving average lag days from lag 01 to lag 06 (b); The Y-axis is the percent increases of daily outpatient visits; the points indicate central estimates; Bars, 95% confidence intervals

Table 3 summarizes the results for possible effect of modification by age, gender, and season at lag 06 days. For age and gender subgroups, the percent increases of outpatient visits due to total causes, RED, CVD, GUD and GID were statistically significant and positive, except CVD and GID who aged 0 to 5 years. The percent increases between CO and outpatient visits varied by gender and age subgroups, but were similar with the overall patients in different outpatient categories. The associations appeared to be more notable for the old patients (age ≥ 65) except for GUD outpatient visits induced by CO, although their between-age difference was statistically insignificant. The association between ambient CO concentration and number of NPD outpatient visits was only statistically significant for the old patients (age ≥ 65). We found CO were related to increased risk of total-causes and CVD outpatient visits in both warm and cool seasons while the associations became insignificant for other outpatient categories in the cool season. The associations for all of the outpatient categories except GUD were statistically significant and stronger in the warm seasons than in cool seasons and the difference was statistically significant for outpatient visits due to total causes, CVD and NPD.

Table 3 Associations of daily outpatient visits by age, sex and season with ambient CO

Figure 2 shows the results for outpatient categories of multiple outcomes with a 1-mg/m3 increase in CO at lag 06 in multi-pollutants models. The associations of CO and outpatient visits for total causes, RED, CVD, GUD, GID and NPD were still stable and statistically significant after the adjustments of the five air pollutants (PM2.5, PM10, SO2, NO2 and O3), and were strengthened, especially with particulate matter adjustments. For example, the percent increases for total-causes outpatient visits at lag 06 days were 24.67% (14.48, 34.85%) in single-model contained CO, and the observation was correlated with a 36.85% (23.26, 50.45%) and 29.24% (17.20,41.27%) visits rise in two-pollutant models adjusted for PM2.5 and PM10, respectively. The effects by other pollutants in the multi-pollutant models are displayed in Additional file 1: Table S1.

Fig. 2
figure2

Percent increases of outpatient visits associated with 1-mg/m3 increase in CO in multi-pollutant models. Abbreviation: RED respiratory diseases, CVD cardiovascular diseases, GUD genitourinary diseases, GID gastrointestinal diseases, NPD neuropsychiatric diseases. Note: All the models were constructed for pollutant at lag06. Model1: Single-pollutant model for CO at lag06; model2: six-pollutants model including PM2.5, PM10, NO2, SO2, O3 and CO; model3: two-pollutant model adjusted for PM2.5; model4: two-pollutant model adjusted for PM10; two-pollutant model adjusted for NO2; two-pollutant model adjusted for SO2; two-pollutant model adjusted for O3. The points indicate central estimates; Bars, 95% confidence intervals

Figure 3 shows the exposure-response (E-R) associations between CO concentrations at lag 06 days and outpatient visits for total causes, RED, CVD, GUD, GID and NPD. The E–R relationships for CO with CVD and GUD outpatient visits were almost linear, showing no thresholds for their associations. For the curve of CO with RED outpatient visits, we observed a relatively flat slope at concentrations below 1 mg/m3, and then a drastic increase at concentrations 1 mg/m3 to 1.5 mg/m3. The E–R curve of CO with total and GID outpatient visits showed a moderately positive association. The curve of CO with NPD outpatient visits showed a relatively flat slope at concentration 0.5 mg/m3 to about 2 mg/m3.

Fig. 3
figure3

The exposure-response relationship curves between CO concentrations at lag06 and daily cause-specific outpatient visits. Abbreviation: RED respiratory diseases, CVD cardiovascular diseases, GUD genitourinary diseases, GID gastrointestinal diseases, NPD neuropsychiatric diseases. Note: The X-axis is the concentrations of air pollutants on the lag06 days (lag06 was concentration computed as the means of the same and previous 6 days); The Y-axis is the log relative risk; The solid line represents the predicted log relative risk, and the dotted lines represent the 95% CI

Discussion

This study examined the acute effect of ambient CO on outpatient visits for total causes, RED, CVD, GUD, GID and NPD in Yichang, China. We found positive associations between CO and outpatient visits for multiple outcomes (total causes, RED, CVD, GUD, GID and NPD outpatient visits) on different lag days. The effect on outpatient visits was immediate and can persist for up to seven days, and all the estimated risks increased as the moving average of longer lag days were considered. To the best of our knowledge, this is the first multi-outcome study for ambient CO in low- and middle-income countries, to examine the relationship between CO and outpatient visits for total causes, RED, CVD, GUD, GID and NPD.

Our findings about the adverse effects of CO for outpatient visits of different diseases were generally in consistent with previous studies [20,21,22,23,24]. Most articles indicated that ambient CO was related to increased hospital visits or admissions for RED and CVD. A study in Spokane, Washington showed that ambient CO exhibited a positive association with RED emergency room visits and showed larger effects at longer lag days for CO [21]. A 1 ppm increase in the 3-day lag of CO was associated with a 1.03-fold increase in respiratory emergency room visits [21] which is very close to our results for RED (1.07-fold increase per ppm increase in CO at lag3). A meta-analysis showed the association between CO and emergency room visits/hospital admissions for asthma in the overall analyses (42 studies) were positive, and the pooled relative risks were 1.07-fold increase per 1 mg/m3 increase in CO [24] which is a little smaller than our results for all RED (1.10-fold increase per 1 mg/m3 increase in CO). Szyszkowicz [25] used a generalized linear mixed model found a significant association between 0.2 ppm ambient CO and emergency department visits for ischemic heart disease (5.4% [95% CI, 2.3, 8.5%]) which is bigger than our results for all CVD (2.5% [95% CI, 0.8, 4.2%] for 0.2 ppm CO). A multi-city time-series analysis in Canada [22] showed that day average concentrations of CO exhibited the positive associations with visits for myocardial infarction/angina for (2.1% [95% CI, 0.0, 4.2%]) increase in per 0.7 ppm CO and 3.8% (95% CI, 0.7, 6.9%) increase in visits for heart failure, which is smaller than our results for CVD (8.7% [95% CI, 2.7, 14.7%] for 0.7 ppm CO). As for NPD, in six cities of Canada, the percentage increase in daily hospital visits for depression was 6.9%(95% CI, 3.8, 10.1%) for CO per 0.8 ppm for same day exposure [20], almost twice our results for NPD (3.1% [95% CI, − 2.3, 8.6%] for 0.8 ppm CO). The study at 6 Italian cities showed that CO was most strongly associated with acute respiratory diseases hospital visits in 7 day average and the association between CO and gastroenteric disorders hospitalizations were also statistically significant among young children [4]. The effect size of the association for gastroenteric disorders was a 3.8% increase (95% CI, 1.0, 6.8%) per 1.1 μg/m3 increase in CO, which is substantially larger than our estimates. In addition, no studies examined associations between ambient CO and visits for GUD diseases and only a few studies examined pooled estimates for total outpatient visits associated with ambient CO.

However, the effects of CO on hospital visits or admissions varies considerably, especially at low levels of exposure, and conflicting results were documented. In Hong Kong, a study found a negative association between CO and risk of respiratory tract infection hospitalizations [7] and the results of some studies were negative associations between ambient CO and stroke emergency hospitalization and chronic obstructive pulmonary diseases hospitalization [8, 26]. The differences between our results and previous findings may be due to different study designs, different locations, various climate, air pollution mixture and study population. Possibly because of the higher levels of air pollution, a stronger temporal association was observed of the ambient CO concentrations on the current day for heart failure and myocardial infarction/angina hospitalizations and hospital visits [12, 13, 22]. However, the ambient CO concentrations in Yichang are mainly at a low level (the maximum daily average is 2.6 mg/m3), and may need more than one day to have increased health outcomes. The cumulative effect display similar temporal patterns in the multi-cities study, that the estimated risks for CO were consistently larger for the moving averages with longer lags and the strongest association for CO was at lag 06 [4]. The structure of the local health service might affect the interpretation of the observed lag effects as it may take a few days or longer to arrange an outpatient appointment rather than the time it took for CO to exert its health effects. We believe the time duration required for outpatient clinic attendances is not likely to cause any biases in this study because Yichang is a typical middle sized Chinese city where the residents normally don’t need to make arrangements for the outpatient visits and the observed lag estimates can reflect the acute effects of CO.

We found that the associations of ambient CO with all of the outpatient visits categories were stronger in warm seasons than in cool seasons which is consistent with previous research [20, 22, 23]. The stronger associations in warm seasons may be attributable to higher personal exposure to ambient air pollutants in relation to more outdoor activities and natural ventilation [27]. Besides, high temperature and strong light in warm seasons lead to enhanced photochemical reactions, resulting in stronger effects [27]. While some researchers believe that infectious diseases also show some seasonal changes, most studies do not consider this factor may lead to certain deviations [28]. Other studies suggest the biological mechanisms that elevated temperatures in warm seasons cause the thermoregulatory system to activate three major mechanisms to dissipate excess body heat (cardiovascular, respiratory activity, and sweat gland perspiration), and that activation directly or indirectly promotes more pollution enter into the body.

With adjustment for other pollutants, the association remained stable and strengthened, particularly with PM2.5 and PM10 adjustment. Given the correlations among various pollutants, it is difficult to disentangle the effects of ambient CO. However, the collinearity between CO and other ambient pollutants can be addressed for the r < 0.7 in our study (except PM10, r = 0.77) [29]. The shape of the E-R plot plays a role in public health assessment. In the present study, we did not observe threshold concentrations for ambient CO level with CVD and GUD outpatient visits while the risk for RED outpatient visits increased drastically at concentrations of 1 mg/m3 which is much lower than WHO standard. The E-R relationship between CO and outpatient visits is important for understanding the causal mechanisms of the relationship and for management of local health systems. Prior research has shown substantial heterogeneity between regions and cities [30], and it is essential to have localised E-R relationships for proper prevention.

In recent years, some researchers have begun to study the associations between ambient CO and other diseases besides respiratory and cardiovascular systems [4, 14]. In our study, we found the associations between CO and outpatient visits for NPD, GID and GUD were statistically significant and positive. For NPD, there is accumulating evidence that outdoor air pollution may have a significant impact on health and disease can adversely affect the brain and nervous system in human and animal studies [31,32,33]. CO, as a known neurotoxin and a potential public health threat, can cross the placenta to gain access to the fetal circulation and the developing brain [34]. Oxidative stress has been recognized as one of the main pathways by which air pollutants cause damage to cardiovascular and respiratory systems [35]. Likewise, it may also be hypothesized that air pollution may impair the nervous system through oxidative stress pathways. As for GID, although the exact mechanisms are unclear, the associations between CO and increased GID outpatient visits are somewhat biologically plausible. For example, gastroenteritis is an inflammation of the gastrointestinal tract that could be caused by infection or by adverse reaction to ingested or inhaled material so it is possible that CO are involved in the mechanism [4]. As the best of our knowledge, this is the first study to report this association of CO and GUD outpatient visits and the mechanisms underlying these effects are not well known. In light of the limited evidence in the association of CO with various diseases, verification of these associations in further studies would be necessary.

This study has several strengths. First, although previous studies have shown that increased ambient CO is associated with excess hospital visits on specific diseases, few studies were devoted to pooled estimates of ambient CO health effects using overall outpatient visits. We studied the outpatient visits for total-causes to get comprehensive estimate of health effects for CO pollution which is necessary to implement better disease control policy. Second, this study allowed us to investigate the effects of CO level on outpatient visits for RED, CVD, GUD, GID and NPD in the same setting and the same period. To the best of our knowledge, this is the first multi-outcome study for ambient CO and this could help better understand adverse effects of ambient CO to different body system. Thus, the data in our study may be important to consider when the standards and guidelines are evaluated and revised in the future. Third, many other recent studies have been based on fewer than 10,000 visits, and have examined single conditions or were restricted to specific seasons or age groups. The large sample size of 5.4 million outpatient visits in our study gives us more statistical power than many of those in other studies conducted in China. Fourth, it should be noted that risk estimates of many studies were mostly based on hospital admission data rather than on the timing of symptom onset, possibly leading to underestimation of effects [36]. Therefore, the data on outpatient visits may better reflect the acute effects of health and reduce the confounding bias. Besides, there may be many confounding factors when the patient’s condition is critical and complex in the emergency rooms and the diagnosis is prone to error, so an analysis of the outpatient visits is better to reflect health effects of ambient CO exposure. Finally, by using a time-series approach, as opposed to a case-crossover approach, this study was more effective for controlling meteorological variables, which was particularly important in this study because an entirely new location was under study [37].

Our study was subject to several limitations. First, the use of citywide average air pollution levels calculated from various monitoring stations rather than personal exposure measures will result in exposure misclassification because of the spatial distribution of ambient CO in urban areas, tending to underestimate the risk [38]. Extensive research has not been conducted on the relationship between personal exposure to CO and ambient measurements. Second, the potential misclassification caused by coding or diagnostic errors should be considered when interpreting the findings. It is not likely to be a problem in this study because all the data coming from different outpatient departments underwent stringent quality check and coding verification before they were included in the big data platform. Third, we could not obtain data on more specific subtypes for RED, CVD, GUD, GID and NPD, leading to the failure in a comprehensive analysis on air pollution and specific diseases, like cerebrovascular disease, which showed mixed results in previous studies [3, 8]. Fourth, our analysis focused on only one Chinese city, thus, the generalizability of our results is limited. Nonetheless, Yichang is one of only a few cities in China where data from all hospitals are collected in a systematic manner to one database, can ensure the comprehensive, accurate and real-time data of hospitals.

Conclusions

In conclusion, the present study provides evidence that CO increased total and cause-specific outpatient visits, can increase the risk of RED, CVD, GSD, GID and NPD, especially in the warm seasons. These findings reinforce the importance of ambient CO controls and disease prevention in less polluted areas, and warn the public about the atmospheric CO factors that could impact public health.

Abbreviations

95% CI:

95% confidence interval

CDC:

Center for Disease Control and Prevention

CO:

Carbon monoxide

CVD:

Cardiovascular diseases

df:

Degrees of freedom

E-R:

Exposure-response

GAM:

Generalized additive model

GID:

Gastrointestinal diseases

GUD:

Genitourinary diseases

ICD:

International Classification of Diseases

max:

maximal

min:

minimal

NO2 :

Nitrogen dioxide

NPD:

Neuropsychiatric diseases

O3 :

Ozone

PM10 :

Particles < 10 μm

PM2.5 :

Particles < 2.5 μm

RED:

Respiratory diseases

RH:

Relative humidity

SD:

Standard deviation

SO2 :

Sulfur dioxide

WHO:

World Health Organization

References

  1. 1.

    Varon J, Marik PE, Fromm RJ, Gueler A. Carbon monoxide poisoning: a review for clinicians. J EMERG MED. 1999;17(1):87–93.

  2. 2.

    Liu C, Yin P, Chen R, Meng X, Wang L, Niu Y, et al. Ambient carbon monoxide and cardiovascular mortality: a nationwide time-series analysis in 272 cities in China. Lancet Planet Health. 2018;2(1):e12–8.

  3. 3.

    Bell ML, Peng RD, Dominici F, Samet JM. Emergency hospital admissions for cardiovascular diseases and ambient levels of carbon monoxide: results for 126 United States urban counties, 1999-2005. CIRCULATION. 2009;120(11):949–55.

  4. 4.

    Orazzo F, Nespoli L, Ito K, Tassinari D, Giardina D, Funis M, et al. Air pollution, aeroallergens, and emergency room visits for acute respiratory diseases and gastroenteric disorders among young children in six Italian cities. Environ Health Perspect. 2009;117(11):1780–5.

  5. 5.

    Ryter SW, Kim HP, Nakahira K, Zuckerbraun BS, Morse D, Choi AM. Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system. Antioxid Redox Signal. 2007;9(12):2157–73.

  6. 6.

    Ryter SW, Morse D, Choi AM. Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. Am J Respir Cell Mol Biol. 2007;36(2):175–82.

  7. 7.

    Tian L, Qiu H, Pun VC, Lin H, Ge E, Chan JC, et al. Ambient carbon monoxide associated with reduced risk of hospital admissions for respiratory tract infections. Am J Respir Crit Care Med. 2013;188(10):1240–5.

  8. 8.

    Tian L, Qiu H, Pun VC, Ho KF, Chan CS, Yu IT. Carbon monoxide and stroke: a time series study of ambient air pollution and emergency hospitalizations. Int J Cardiol. 2015;201:4–09.

  9. 9.

    Cai J, Chen R, Wang W, Xu X, Ha S, Kan H. Does ambient CO have protective effect for COPD patient? Environ Res. 2015;136:21–6.

  10. 10.

    Schwartz J, Coull BA. Control for confounding in the presence of measurement error in hierarchical models. BIOSTATISTICS. 2003;4(4):539–53.

  11. 11.

    Franck U, Leitte AM, Suppan P. Multifactorial airborne exposures and respiratory hospital admissions--the example of Santiago de Chile. Sci Total Environ. 2015;502:114–21.

  12. 12.

    Wellenius GA, Bateson TF, Mittleman MA, Schwartz J. Particulate air pollution and the rate of hospitalization for congestive heart failure among medicare beneficiaries in Pittsburgh, Pennsylvania. Am J Epidemiol. 2005;161(11):1030–6.

  13. 13.

    Liu H, Tian Y, Song J, Cao Y, Xiang X, Huang C, et al. Effect of ambient air pollution on hospitalization for heart failure in 26 of China's largest cities. Am J Cardiol. 2018;121(5):628–33.

  14. 14.

    Chen C, Liu C, Chen R, Wang W, Li W, Kan H, et al. Ambient air pollution and daily hospital admissions for mental disorders in Shanghai, China. Sci Total Environ. 2018;613-614:324–30.

  15. 15.

    Chen R, Chu C, Tan J, Cao J, Song W, Xu X, et al. Ambient air pollution and hospital admission in Shanghai, China. J Hazard Mater. 2010;181(1–3):234–40.

  16. 16.

    Cai J, Zhao A, Zhao J, Chen R, Wang W, Ha S, et al. Acute effects of air pollution on asthma hospitalization in Shanghai, China. Environ Pollut. 2014;191:139–44.

  17. 17.

    Bell ML, Davis DL, Fletcher T. A retrospective assessment of mortality from the London smog episode of 1952: the role of influenza and pollution. Environ Health Perspect. 2004;112(1):6–08.

  18. 18.

    Bai L, Su X, Zhao D, Zhang Y, Cheng Q, Zhang H, et al. Exposure to traffic-related air pollution and acute bronchitis in children: season and age as modifiers. J Epidemiol Community Health. 2018;72(5):426–33.

  19. 19.

    Yang CY. Air pollution and hospital admissions for congestive heart failure in a subtropical city: Taipei, Taiwan. J Toxicol Environ Health A. 2008;71(16):1085–90.

  20. 20.

    Szyszkowicz M, Rowe BH, Colman I. Air pollution and daily emergency department visits for depression. Int J Occup Med Environ Health. 2009;22(4):355–62.

  21. 21.

    Slaughter JC, Kim E, Sheppard L, Sullivan JH, Larson TV, Claiborn C. Association between particulate matter and emergency room visits, hospital admissions and mortality in Spokane, Washington. J Expo Anal Environ Epidemiol. 2005;15(2):153–9.

  22. 22.

    Stieb DM, Szyszkowicz M, Rowe BH, Leech JA. Air pollution and emergency department visits for cardiac and respiratory conditions: a multi-city time-series analysis. Environ Health. 2009;8:25.

  23. 23.

    Tramuto F, Cusimano R, Cerame G, Vultaggio M, Calamusa G, Maida CM, et al. Urban air pollution and emergency room admissions for respiratory symptoms: a case-crossover study in Palermo, Italy. Environ Health. 2011;10:31.

  24. 24.

    Zheng XY, Ding H, Jiang LN, Chen SW, Zheng JP, Qiu M, et al. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One. 2015;10(9):e138146.

  25. 25.

    Szyszkowicz M. Air pollution and emergency department visits for ischemic heart disease in Montreal, Canada. Int J Occup Med Environ Health. 2007;20(2):167–73.

  26. 26.

    Tian L, Ho KF, Wang T, Qiu H, Pun VC, Chan CS, et al. Ambient carbon monoxide and the risk of hospitalization due to chronic obstructive pulmonary disease. Am J Epidemiol. 2014;180(12):1159–67.

  27. 27.

    Chen R, Peng RD, Meng X, Zhou Z, Chen B, Kan H. Seasonal variation in the acute effect of particulate air pollution on mortality in the China air pollution and health effects study (CAPES). Sci Total Environ. 2013;450-451:259–65.

  28. 28.

    Peng RD, Dominici F, Pastor-Barriuso R, Zeger SL, Samet JM. Seasonal analyses of air pollution and mortality in 100 US cities. Am J Epidemiol. 2005;161(6):585–94.

  29. 29.

    Ko FW, Tam W, Wong TW, Lai CK, Wong GW, Leung TF, et al. Effects of air pollution on asthma hospitalization rates in different age groups in Hong Kong. Clin Exp Allergy. 2007;37(9):1312–9.

  30. 30.

    Yin P, He G, Fan M, Chiu KY, Fan M, Liu C, et al. Particulate air pollution and mortality in 38 of China's largest cities: time series analysis. BMJ. 2017;356:j667.

  31. 31.

    Lucchini RG, Dorman DC, Elder A, Veronesi B. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotoxicology. 2012;33(4):838–41.

  32. 32.

    Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, et al. The outdoor air pollution and brain health workshop. Neurotoxicology. 2012;33(5):972–84.

  33. 33.

    Block ML, Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 2009;32(9):506–16.

  34. 34.

    Levy RJ. Carbon monoxide pollution and neurodevelopment: a public health concern. Neurotoxicol Teratol. 2015;49:31–40.

  35. 35.

    Kelly FJ. Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med. 2003;60(8):612–6.

  36. 36.

    Zeger SL, Thomas D, Dominici F, Samet JM, Schwartz J, Dockery D, et al. Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect. 2000;108(5):419–26.

  37. 37.

    Fung KY, Krewski D, Chen Y, Burnett R, Cakmak S. Comparison of time series and case-crossover analyses of air pollution and hospital admission data. Int J Epidemiol. 2003;32(6):1064–70.

  38. 38.

    Goldman GT, Mulholland JA, Russell AG, Strickland MJ, Klein M, Waller LA, et al. Impact of exposure measurement error in air pollution epidemiology: effect of error type in time-series studies. Environ Health. 2011;10:61.

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Acknowledgements

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

YW and CY performed the analyses and wrote the manuscript. CX, XZ, MZ, YL conducted the study, data analysis, reviewed and edited the manuscript. PZ and PY researched the data, conceived the research, provided overall supervision, and reviewed and edited the manuscript. PZ and PY are the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors read and approved the final manuscript.

Correspondence to Pei Zhang or Peng Yin.

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Additional file

Additional file 1:

Table S1. Associations of daily outpatient visits with ambient air pollutants in six-pollutant models. (DOCX 15 kb)

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Wang, Y., Yao, C., Xu, C. et al. Carbon monoxide and risk of outpatient visits due to cause-specific diseases: a time-series study in Yichang, China. Environ Health 18, 36 (2019) doi:10.1186/s12940-019-0477-3

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Keywords

  • Air pollution
  • Carbon monoxide
  • Outpatient visit
  • Health effect
  • Time-series study

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