Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental toxicity. The Lancet Neurol. 2014;13(3):330–8.
Article
CAS
Google Scholar
Bouchard TJ Jr, McGue M. Familial studies of intelligence: a review. Science. 1981;212(4498):1055–9.
Article
Google Scholar
Chabris CF, Hebert BM, Benjamin DJ, Beauchamp J, Cesarini D, van der Loos M, Johannesson M, Magnusson PK, Lichtenstein P, Atwood CS, et al. Most reported genetic associations with general intelligence are probably false positives. Psychol Sci. 2012;23(11):1314–23.
Article
Google Scholar
Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, Ke X, Le Hellard S, Christoforou A, Luciano M, et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry. 2011;16(10):996–1005.
Article
CAS
Google Scholar
Davis OS, Butcher LM, Docherty SJ, Meaburn EL, Curtis CJ, Simpson MA, Schalkwyk LC, Plomin R. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. Behav Genet. 2010;40(6):759–67.
Article
Google Scholar
Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH, Nadeau JH. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet. 2010;11(6):446–50.
Article
CAS
Google Scholar
Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, Palazuelos E, Weiss ST, Hernandez-Avila M. Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res. 2003;54(6):819–25.
Article
CAS
Google Scholar
Bellinger D, Leviton A, Waternaux C, Needleman H, Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med. 1987;316(17):1037–43.
Article
CAS
Google Scholar
Bellinger DC. Lead. Pediatrics. 2004;113(4 Suppl):1016–22.
Google Scholar
Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL, Dietrich KN, Bornschein R, Greene T, et al. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect. 2005;113(7):894–9.
Article
CAS
Google Scholar
Rodier PM. Environmental causes of central nervous system maldevelopment. Pediatrics. 2004;113(4 Suppl):1076–83.
Google Scholar
Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying Children's susceptibility to environmental toxicants. Environ Health Perspect. 2000;108(Suppl 1):13–21.
Article
CAS
Google Scholar
Bressler J, Kim KA, Chakraborti T, Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem Res. 1999;24(4):595–600.
Article
CAS
Google Scholar
Lasley SM, Gilbert ME. Presynaptic glutamatergic function in dentate gyrus in vivo is diminished by chronic exposure to inorganic lead. Brain Res. 1996;736(1–2):125–34.
Article
CAS
Google Scholar
Bellinger D, Sloman J, Leviton A, Rabinowitz M, Needleman HL, Waternaux C. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics. 1991;87(2):219–27.
CAS
Google Scholar
Bellinger DC, Stiles KM, Needleman HL. Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. Pediatrics. 1992;90(6):855–61.
CAS
Google Scholar
Burris HH, Braun JM, Byun HM, Tarantini L, Mercado A, Wright RJ, Schnaas L, Baccarelli AA, Wright RO, Tellez-Rojo MM. Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu. Epigenomics. 2013;5(3):271–81.
Article
CAS
Google Scholar
Kile ML, Rodrigues EG, Mazumdar M, Dobson CB, Diao N, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health. 2014;13(1):29.
Article
Google Scholar
Gleason K, Shine JP, Shobnam N, Rokoff LB, Suchanda HS, Ibne Hasan MO, Mostofa G, Amarasiriwardena C, Quamruzzaman Q, Rahman M, et al. Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. J Environ Public Health. 2014;2014:730636.
Article
Google Scholar
Renzetti S, Just AC, Burris HH, Oken E, Amarasiriwardena C, Svensson K, Mercado-Garcia A, Cantoral A, Schnaas L, Baccarelli AA, et al. The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort. Environ Res. 2017;152:226–32.
Article
CAS
Google Scholar
Hossain S, Bhowmick S, Jahan S, Rozario L, Sarkar M, Islam S, Basunia MA, Rahman A, Choudhury BK, Shahjalal H. Maternal lead exposure decreases the levels of brain development and cognition-related proteins with concomitant upsurges of oxidative stress, inflammatory response and apoptosis in the offspring rats. Neurotoxicology. 2016;56:150–8.
Article
CAS
Google Scholar
Capurro H, Konichezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr. 1978;93(1):120–2.
Article
CAS
Google Scholar
Caldwell BM, Bradley RH. Home observation for measurement of the environment: administration manual. Tempe: Family & Human Dynamics Research Institute, Arizona State University; 2003.
Google Scholar
Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT. Data quality control in genetic case-control association studies. Nat Protoc. 2010;5(9):1564–73.
Article
CAS
Google Scholar
Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139–40.
Article
CAS
Google Scholar
Pirkle JL, Brody DJ, Gunter EW, Kramer RA, Paschal DC, Flegal KM, Matte TD. The decline in blood lead levels in the United States. The National Health and nutrition examination surveys (NHANES). JAMA. 1994;272(4):284–91.
Article
CAS
Google Scholar
Zheng L, Wu K, Li Y, Qi Z, Han D, Zhang B, Gu C, Chen G, Liu J, Chen S, et al. Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China. Environ Res. 2008;108(1):15–20.
Article
CAS
Google Scholar
Lee S, Wright FA, Zou F. Control of population stratification by correlation-selected principal components. Biometrics. 2011;67(3):967–74.
Article
Google Scholar
Tibshirani R. Regression shrinkage and selection via the lasso. J R Stat Soc Ser B Methodol. 1996;58(1):267–88.
Google Scholar
Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190–1.
Article
CAS
Google Scholar
Kircher M, Witten D, Jain P, O'Roak B, Cooper G, Shendure J. A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 2014;46(3):310–5.
Article
CAS
Google Scholar
Takemoto M, Hattori Y, Zhao H, Sato H, Tamada A, Sasaki S, Nakajima K, Yamamoto N. Laminar and areal expression of unc5d and its role in cortical cell survival. Cereb Cortex. 2011;21(8):1925–34.
Article
Google Scholar
Howie B, Marchini J, Stephens M. Genotype imputation with thousands of genomes. G3 (Bethesda). 2011;1(6):457–70.
Article
Google Scholar
Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, et al. Spatio-temporal transcriptome of the human brain. Nature. 2011;478(7370):483–9.
Article
CAS
Google Scholar
Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Upregulated Genes and Cognitive Scores in Children. Environ Health Perspect. 2017;125(4):721–29.
Shao Z, Kamboj A, Anderson CM. Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures. J Neurosci Res. 2009;87(11):2520–30.
Article
CAS
Google Scholar
Chang BL, Zheng SL, Hawkins GA, Isaacs SD, Wiley KE, Turner A, Carpten JD, Bleecker ER, Walsh PC, Trent JM, et al. Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility. Cancer Res. 2002;62(6):1784–9.
CAS
Google Scholar
Keleman K, Dickson BJ. Short- and long-range repulsion by the drosophila Unc5 netrin receptor. Neuron. 2001;32(4):605–17.
Article
CAS
Google Scholar
Wang H, Ozaki T, Shamim Hossain M, Nakamura Y, Kamijo T, Xue X, Nakagawara A. A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. Biochem Biophys Res Commun. 2008;370(4):594–8.
Article
CAS
Google Scholar
Utami KH, Hillmer AM, Aksoy I, Chew EG, Teo AS, Zhang Z, Lee CW, Chen PJ, Seng CC, Ariyaratne PN, et al. Detection of chromosomal breakpoints in patients with developmental delay and speech disorders. PLoS One. 2014;9(6):e90852.
Article
Google Scholar
Gardella C. Lead exposure in pregnancy: a review of the literature and argument for routine prenatal screening. Obstet Gynecol Surv. 2001;56(4):231–8.
Article
CAS
Google Scholar
Dietrich KN, Succop PA, Bornschein RL, Krafft KM, Berger O, Hammond PB, Buncher CR. Lead exposure and neurobehavioral development in later infancy. Environ Health Perspect. 1990;89:13–9.
Article
CAS
Google Scholar
Grewer C, Gameiro A, Rauen T. SLC1 glutamate transporters. Pflugers Arch. 2014;466(1):3–24.
Article
CAS
Google Scholar
Masliah E, Alford M, DeTeresa R, Mallory M, Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol. 1996;40(5):759–66.
Article
CAS
Google Scholar
Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med. 1992;326(22):1464–8.
Article
CAS
Google Scholar
Seki Y, Feustel PJ, Keller RW Jr, Tranmer BI, Kimelberg HK. Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker. Stroke. 1999;30(2):433–40.
Article
CAS
Google Scholar
Needleman HL. Childhood lead poisoning. Curr Opin Neurol. 1994;7(2):187–90.
Article
CAS
Google Scholar
Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med. 2003;348(16):1517–26.
Article
CAS
Google Scholar
Claus Henn B, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernandez-Avila M, Amarasiriwardena C, Hu H, Bellinger DC, Wright RO, et al. Associations of early childhood manganese and lead coexposure with neurodevelopment. Environ Health Perspect. 2012;120(1):126–31.
Article
Google Scholar
Bellinger DC. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr. 2008;20(2):172–7.
Article
Google Scholar
Roy A, Bellinger D, Hu H, Schwartz J, Ettinger AS, Wright RO, Bouchard M, Palaniappan K, Balakrishnan K. Lead exposure and behavior among young children in Chennai, India. Environ Health Perspect. 2009;117(10):1607–11.
Article
CAS
Google Scholar
Bellinger DC. Neurological and behavioral consequences of childhood lead exposure. PLoS Med. 2008;5(5):e115.
Article
Google Scholar
Struzynska L. A glutamatergic component of lead toxicity in adult brain: the role of astrocytic glutamate transporters. Neurochem Int. 2009;55(1–3):151–6.
Article
CAS
Google Scholar
Toscano CD, Guilarte TR. Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev. 2005;49(3):529–54.
Article
CAS
Google Scholar
Trotti D, Danbolt NC, Volterra A. Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol Sci. 1998;19(8):328–34.
Article
CAS
Google Scholar
Coppi AA, Lesniak J, Zieba D, Schanne FA. The effects of lead on PKC isoforms. Ann N Y Acad Sci. 2000;919:304–6.
Article
CAS
Google Scholar
Sun X, Tian X, Tomsig JL, Suszkiw JB. Analysis of differential effects of Pb2+ on protein kinase C isozymes. Toxicol Appl Pharmacol. 1999;156(1):40–5.
Article
CAS
Google Scholar
Rajan MT, Jagannatha Rao KS, Mamatha BM, Rao RV, Shanmugavelu P, Menon RB, Pavithran MV. Quantification of trace elements in normal human brain by inductively coupled plasma atomic emission spectrometry. J Neurol Sci. 1997;146(2):153–66.
Article
CAS
Google Scholar
Brodie C, Blumberg PM. Regulation of cell apoptosis by protein kinase c delta. Apoptosis. 2003;8(1):19–27.
Article
CAS
Google Scholar
Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxid Redox Signal. 2003;5(5):609–20.
Article
CAS
Google Scholar
Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):287–99.
Article
Google Scholar
Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Hum Reprod Update. 2006;12(6):747–55.
Article
CAS
Google Scholar
Qian Y, Tiffany-Castiglioni E. Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system. Neurochem Res. 2003;28(1):153–62.
Article
CAS
Google Scholar
Floc'h N, Kolodziejski J, Akkari L, Simonin Y, Ansieau S, Puisieux A, Hibner U, Lassus P. Modulation of oxidative stress by twist oncoproteins. PLoS One. 2013;8(8):e72490.
Article
Google Scholar
Luningschror P, Kaltschmidt B, Kaltschmidt C. Knockdown of IKK1/2 promotes differentiation of mouse embryonic stem cells into neuroectoderm at the expense of mesoderm. Stem Cell Rev. 2012;8(4):1098–108.
Article
Google Scholar
Vincentz JW, Firulli BA, Lin A, Spicer DB, Howard MJ, Firulli AB. Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest. PLoS Genet. 2013;9(3):e1003405.
Article
CAS
Google Scholar
Braun JM, Hoffman E, Schwartz J, Sanchez B, Schnaas L, Mercado-Garcia A, Solano-Gonzalez M, Bellinger DC, Lanphear BP, Hu H, et al. Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children. Neurotoxicology. 2012;33(5):1040–7.
Article
CAS
Google Scholar
McCarty KM, Senn DB, Kile ML, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC. Antimony: an unlikely confounder in the relationship between well water arsenic and health outcomes in Bangladesh. Environ Health Perspect. 2004;112(8):809–11.
Article
CAS
Google Scholar