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Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh

Environmental Health volume 21, Article number: 13 (2022) Cite this article

Abstract

Background

Arsenic exposure has been associated with gestational diabetes mellitus. However, the extent to which arsenic exposure during pregnancy is associated with postpartum glucose intolerance is unknown.

Methods

We studied 323 women in Bangladesh. We assessed arsenic exposure in early pregnancy via toenail and water samples. We measured fasting glucose and insulin in serum at a mean (SD) of 4.0 (3.5) weeks post-delivery. We ran covariate-adjusted, linear regression models to examine associations of arsenic concentrations with HOMA-IR, a marker of insulin resistance, and HOMA-β, a marker of beta cell function.

Results

Median (IQR) arsenic concentration was 0.45 (0.67) μg/g in toenails and 2.0 (6.5) μg/L in drinking water. Arsenic concentrations during pregnancy were not associated with insulin resistance or beta cell function postpartum. HOMA-IR was 0.07% (− 3.13, 3.37) higher and HOMA-β was 0.96% (− 3.83, 1.99) lower per IQR increment in toenail arsenic, but effect estimates were small and confidence intervals crossed the null.

Conclusions

Although arsenic exposure during pregnancy has been consistently associated with gestational diabetes mellitus, we found no clear evidence for an adverse effect on postpartum insulin resistance or beta cell function.

Peer Review reports

Background

Arsenic, which is naturally-occurring, contaminates the groundwater of many countries, including Bangladesh, Chile, China, India, Mexico, and the United States [1]. Chronic exposure to arsenic in drinking water has been associated with greater risk of adverse health outcomes such as cardiovascular disease and skin, bladder, and lung cancer [2].

Arsenic exposure has also been consistently associated with glucose intolerance and type 2 diabetes in numerous adult cohorts (reviewed in [3, 4]). In vitro and rodent models suggest that arsenic impairs glucose homeostasis by acting to both increase insulin resistance and decrease insulin secretion [3, 5, 6]. Specifically, arsenic accumulates in the pancreas and increases oxidative stress through production of reactive oxygen species which can directly damage pancreatic islet cells [7,8,9]. Arsenic can also interfere with gene expression (i.e., enhances expression of TNF-α, and IL-6 and inhibits expression of PPAR-γ) to directly increase insulin resistance [10,11,12]. Consistent with these mechanistic underpinnings, studies of arsenic exposure with biochemical assessment of glucose homeostasis in non-pregnant adults have shown associations with greater insulin resistance [13, 14] and lower insulin secretion [14,15,16,17].

There is also a burgeoning population-based literature linking arsenic exposure during pregnancy with gestational diabetes mellitus (GDM) [17,18,19,20,21,22,23,24,25,26]. However, to our knowledge, these studies have all assessed the clinical outpoint of GDM rather than the mechanistically relevant biochemical markers of insulin resistance and insulin secretion. Also, the prior studies did not examine glycemia in the postpartum period. Characterizing the role of arsenic exposure on glucose tolerance post-delivery is important because glycemic status in the months postpartum is a more sensitive indicator of future type 2 diabetes risk than the diagnosis of GDM itself [26].

Here, we present an analysis of prenatal arsenic exposure (measured in toenail sample and in home water source) and postpartum insulin resistance and beta cell function [measured mean (SD) 4.0 (3.5) months post-delivery] in an arsenic-exposed population in Bangladesh. We hypothesized that women with greater arsenic exposure would have greater insulin resistance and lower insulin secretion.

Methods

Study population and design

In this analysis, we leveraged data collected starting in December 2016 as part of a case-control study of arsenic exposure and neural tube defects in Bangladesh [27]. There was high-level arsenic contamination across Bangladesh due to naturally-occurring arsenic sediment which contaminated the water in the tubewells that Bangladeshi citizens relied on for drinking water. Over the past two decades, the Bangladeshi government and nongovernmental organizations have successfully lowered citizens’ arsenic body burden by installing water filtration devices or color-coding unsafe tubewells [28]. Despite this remediation, arsenic exposure levels in Bangladesh at the time of this study were still orders of magnitude higher than in arsenic-exposed areas of the US [20]. One unique feature of Bangladesh is the wide range of arsenic exposures within the country [29].

We reviewed medical records from the National Institute of Neurosciences and Hospital (NINS) in Dhaka to identify mothers who had presented to the hospital for evaluation of a child with myelomeningocele or meningocele (cases). NINS is a government hospital that draws patients from across the country. We recruited controls from NINS or Dhaka Shishu Hospital, adjacent to NINS. We required controls to have delivered an infant within 6 months of a case and required controls to use a different tube well water source than any of the cases. At study enrollment [mean (SD) 4 (3.5 months) postpartum], trained medical staff confirmed presence (cases) or absence (controls) of a neural tube defect.

The present analysis of arsenic exposure and glucose homeostasis uses data from the full cohort, adjusted for case status. At the time of this analysis, we had data available on 365 women. We excluded 11 participants with pre-existing diabetes, 30 without measures of insulin or glucose, and 1 without a measure of arsenic exposure. In total, we studied 323 participants (164 cases and 159 controls). Our analytic sample size ranged from 320 to 323 depending on the exposure and outcome; one participant was missing a measure of toenail arsenic and was excluded from analyses that involved toenail arsenic. Two participants had a negative HOMA-β related to low glucose and were excluded from analyses that involved HOMA-β. We obtained written informed consent from all participants, and the study was approved by the Human Research Committees at Boston Children’s Hospital (BCH), NINS, and the Bangladesh Medical Research Council.

Measurement of arsenic exposure

We assessed environmental arsenic exposure in two ways, via toenail and water samples [30]. We collected toenail samples from the mother at enrollment, using stainless steel scissors, and we stored samples at room temperature. Samples were analyzed at the Dartmouth Trace Element Core facility using standard total acid digestion procedures [31]. All toenail arsenic values were above the limit of detection (LOD) (0.002 μg/g).

We also collected arsenic samples from the tube well that each participant retrospectively identified as her primary source of drinking water at the time when she became aware of her pregnancy. Because 42% of participants (n = 135) changed their drinking water source at some point during their pregnancy, we examined drinking water arsenic concentrations in a secondary analysis. The Environmental Engineering Laboratory at the Bangladesh University of Engineering and Technology (BUET) analyzed water arsenic concentrations using graphite furnace atomic absorption spectroscopy (SM 3113B) [32]. Twenty-eight percent of samples had a water arsenic concentration below the LOD of 1 μg/L, consistent with other studies from the region which has undergone arsenic remediation following groundwater contamination [29]. For samples below the LOD, we estimated water arsenic concentrations to be LOD/2.

Measurement of insulin resistance and beta cell function

We collected blood samples from participants at enrollment. The Clinical Biochemistry laboratory of Bangabandhu Sheikh Mujib Medical University quantified insulin concentrations using a chemiluminescent microparticle immunoassay on a Ci4100 ARCHITECT plus instrument (Abbott) and NINS clinical laboratory measured glucose concentration using an enzymatic and photometric method. We estimated insulin resistance by calculating the homeostatic model assessment of insulin resistance (HOMA-IR) as [(fasting glucose (mmol/L) × fasting insulin (μU/mL))/22.5]. We estimated beta cell function by calculating the homeostatic model assessment of beta cell function (HOMA-β) as [(20*fasting insulin (μU/mL))/(fasting glucose (mmol/L) – 3.5)].

Measurement of covariates

We collected information on participant age, education, employment, spouse employment, prenatal betel nut use, prenatal smoking, medications during pregnancy (including insulin use), and birth order of the index child during interviews at study enrollment. We assessed intake of rice and fish as part of a food frequency questionnaire previously validated in rural Bangladeshi populations [33]. We recorded information about the blood draw, including timing (months postpartum) and hours fasting.

Statistical analyses

We first fit unadjusted, followed by covariate-adjusted, linear regression models to examine the associations of toenail (primary analysis) and drinking water (secondary analysis) arsenic concentrations with HOMA-IR and HOMA-β. We fit separate linear regression models for each outcome. We ln-transformed HOMA-IR and HOMA-β to meet model assumptions. For ease of interpretation, we exponentiated regression coefficients and reported results as a percent change [% change = (exp (beta) – 1) × 100]. We expressed continuous associations per IQR increment in exposure. We adjusted for covariates potentially associated with arsenic exposure [30, 34,35,36,37] and/or glucose tolerance [38,39,40]. We adjusted for age at enrollment (continuous), prenatal betel nut use (yes or no), education (college, high school or less, or no formal schooling), employment (employed or unemployed), spouse employment [unemployed, office worker (small business owner or private office worker), agricultural laborer or carpenter, or unknown], study group (infant with neural tube defect or control), rice intake [cups per day (continuous)], fish intake [cups per day (continuous)], and characteristics of the blood draw [months postpartum (continuous) and fasting time (continuous)] (Supplemental Fig. 1). Adjustment for prenatal smoking status (2 participants smoked during pregnancy) and birth order of the index child (46% of the index children were the family’s first child) did not appreciably change results, and thus we did not include these covariates in final models.

Next, we performed sensitivity analyses using our final adjusted model. We ran the analyses after excluding one participant with a fasting time of less than 5 h, one participant with an implausible glucose concentration (< 50 mg/dL), and 2 participants who used insulin during pregnancy. We also fit models to test the associations of water arsenic concentrations with HOMA-IR and HOMA-β in the subset of participants (n = 188) who reported a constant water source during pregnancy. Finally, we fit covariate-adjusted penalized spline generalized additive models to visually examine potential non-linear associations of arsenic concentrations with HOMA-IR and HOMA-β.

We used R 4.0.1 (Vienna, Austria) for all analyses.

Results

Of the 323 participants included in the analytic dataset, mean (standard deviation [SD]) age at the time of enrollment was 24.3 (4.7) years. Fifty-four percent of participants had high school or less education and 13% used betel nut prenatally. Median (IQR) HOMA-IR was 1.2 (1.2) and HOMA-β was 84.5 (70.1) (Table 1). Median (IQR) postpartum toenail arsenic concentration was 0.45 (0.67) μg/g and drinking water arsenic concentration was 2.0 (6.5) μg/L. Toenail and drinking water arsenic concentrations were moderately correlated (Spearman’s r = 0.44). As compared to participants with lower toenail arsenic concentrations, participants with higher concentrations had greater betel nut use, greater rice intake, and were more likely to have a spouse who was an office worker (rather than an agricultural laborer or carpenter) (Supplemental Table 1).

Table 1 Characteristics of participants overall (n = 323) and by toenail arsenic concentration (μg/g) (n = 322)
Full size table

In unadjusted and covariate-adjusted models, we found no association between arsenic concentrations during pregnancy and postpartum insulin resistance or beta cell function. Participants with greater toenail and water arsenic had higher insulin resistance (HOMA-IR) and lower beta cell function (HOMA-β), although effect estimates were very small and confidence intervals crossed the null. In covariate-adjusted models, for each IQR increment in toenail arsenic, HOMA-IR was 0.07% (− 3.13, 3.37) higher and HOMA-β was 0.96% (− 3.83, 1.99) lower. For each IQR increment in water arsenic, HOMA-IR was 0.31% (− 0.82, 1.46) higher and HOMA-β was 0.09% (− 1.11, 0.94) lower (Table 2).

Table 2 Percent change (95% CI) in HOMA-IR or HOMA-β per IQR increment in toenail or water arsenic concentrationa
Full size table

The associations of toenail and water arsenic concentrations with HOMA-IR and HOMA-β were not appreciably different when we excluded 4 participants for short fasting time, implausible glucose concentration, and use of insulin during pregnancy (data not shown). In the subset of participants who reported a constant water source during pregnancy, for each IQR increment in water arsenic, HOMA-IR was 0.12% (− 1.41, 1.66) higher and HOMA-β was 0.02% (− 1.33, 1.31) lower, although confidence intervals crossed the null.

In penalized spline generalized additive models, among the majority of participants (arsenic concentrations < 5 μg/g for toenail and < 150 μg/L for water), higher toenail and water arsenic concentrations appeared to be associated with higher HOMA-IR (i.e., worse insulin resistance), and higher toenail arsenic appeared to be associated with higher HOMA- β (improved beta cell function). Among the few participants with very high toenail arsenic concentrations (> 5 μg/g), higher arsenic appeared to be associated with lower HOMA-IR and HOMA- β (i.e., improved insulin resistance but worse beta cell function). Among participants with high water arsenic concentrations (> 150 μg/L) there did not appear to be an association between arsenic and HOMA-IR, and water arsenic concentrations across the range of exposure did not appear to be associated with HOMA- β (Fig. 1).

Fig. 1
figure 1

Covariate-adjusteda generalized additive models showing associations of toenail and water arsenic concentrations with insulin resistance (HOMA-IR) and beta cell function (HOMA-β)

Full size image

Discussion

In a cohort in Bangladesh, we found no association between arsenic exposure during pregnancy and postpartum glucose homeostasis. While women with greater arsenic exposure had greater insulin resistance and lower insulin secretion, effect sizes were small and confidence intervals crossed the null.

To put our results in context of the existing literature, several prior studies [17,18,19,20,21,22,23,24,25,26] conducted in regions across a range of arsenic exposures suggest that women with greater arsenic exposure are more likely to develop GDM during pregnancy. A strength of the present study is our toenail measures of arsenic, as the majority of prior studies only measured arsenic in the urine [17, 18, 22] or blood [24,25,26]. Due to the short (10 h) biological half-life of arsenic, toenail measures which approximate exposure during the 6-12 months prior to collection (i.e., reflecting exposures during early to mid-pregnancy in the present study) provide a more integrated, long-term exposure measure than urine or blood [41, 42]. Another strength of our study is our direct biochemical measures of insulin and glucose. As compared to the prior studies of arsenic exposure during pregnancy which relied on a clinical diagnosis of GDM, we were positioned to detect a more subtle impact of arsenic exposure on insulin resistance and insulin secretion.

Despite our measurement of long-term arsenic exposure and direct biochemical measures of insulin and glucose, in contrast to the prior studies, the association between arsenic exposure and glucose homeostasis did not reach statistical significance in our study. We hypothesize that the impact of arsenic exposure on glucose homeostasis during pregnancy may not persist postpartum, consistent with findings from a recent rodent study [43]. If replicated in other cohorts, this has important clinical implications; while arsenic exposure during pregnancy may increase risk of GDM and associated adverse maternal and fetal perinatal health outcomes, its impact on postpartum glucose tolerance and future risk of type 2 diabetes may be more limited. However, it is possible that the relatively young age of our cohort [mean (SD) 24 (7) years] may have limited our ability to see an association between arsenic exposure and GDM, which is more common in older women [40]. Our wide confidence intervals and the fact that the directionality of our effect estimates was consistent with our a priori hypotheses suggest that we also may have been limited by our relatively small sample size (N > 1000 in the majority of the prior studies of arsenic exposure and GDM [17, 18, 20,21,22, 24, 26]). Thus, our findings warrant replication in larger cohorts of diverse women.

Another novel aspect of our study is that we used spline models to investigate potential non-linear associations between arsenic exposure and postpartum glucose homeostasis. We hypothesized that we might observe protective effects of arsenic on HOMA-IR in women with the highest arsenic concentrations. This was based on recent mouse models that have shown that at higher levels of exposure, arsenic may improve insulin resistance which may offset arsenic-induced impairment in beta-cell function [44,45,46]. Our spline models were somewhat consistent with these rodent data. Among the women with the highest toenail concentrations of arsenic, higher arsenic exposure was associated with worse beta-cell function but lower (i.e., improved) insulin resistance.

Strengths of our study include two measures of arsenic exposure during pregnancy including toenail measures of arsenic exposure and postpartum biochemical measures of both insulin resistance and beta cell function. Limitations of our study include a relatively small sample size and no information on pre-pregnancy body mass index.

Conclusion

In summary, in a Bangladeshi cohort, we found no clear evidence for an adverse effect of arsenic exposure during pregnancy on postpartum insulin resistance or beta cell function. If replicated in other cohorts, our finding has implications for surveillance for abnormal glucose homeostasis among women in arsenic endemic areas of the world.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the study team (maitreyi.mazumdar@childrens.harvard.edu) upon reasonable request.

Abbreviations

CI:

Confidence interval

IQR:

Interquartile range

LOD:

Limit of detection

GDM:

Gestational diabetes mellitus

SD:

Standard deviation

HOMA-IR:

Homeostatic model assessment of insulin resistance

HOMA-β:

Homeostatic model assessment of beta cell function

References

  1. Organization WH: Exposure to arsenic: a major public health concern. 2019.

    Google Scholar 

  2. Kuo CC, Moon KA, Wang SL, Silbergeld E, Navas-Acien A. The association of arsenic metabolism with cancer, cardiovascular disease, and diabetes: a systematic review of the epidemiological evidence. Environ Health Perspect. 2017;125(8):087001.

    Article  Google Scholar 

  3. Maull EA, Ahsan H, Edwards J, Longnecker MP, Navas-Acien A, Pi J, et al. Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review. Environ Health Perspect. 2012;120(12):1658–70.

    Article  CAS  Google Scholar 

  4. Sung TC, Huang JW, Guo HR. Association between arsenic exposure and diabetes: a Meta-analysis. Biomed Res Int. 2015;2015:368087.

    Article  Google Scholar 

  5. Tseng CH. The potential biological mechanisms of arsenic-induced diabetes mellitus. Toxicol Appl Pharmacol. 2004;197(2):67–83.

    Article  CAS  Google Scholar 

  6. Carmean CM, Seino S. Braving the element: pancreatic beta-cell dysfunction and adaptation in response to arsenic exposure. Front Endocrinol (Lausanne). 2019;10:344.

    Article  Google Scholar 

  7. Fu J, Woods CG, Yehuda-Shnaidman E, Zhang Q, Wong V, Collins S, et al. Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect. 2010;118(6):864–70.

    Article  CAS  Google Scholar 

  8. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, et al. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007;56(7):1783–91.

    Article  CAS  Google Scholar 

  9. Izquierdo-Vega JA, Soto CA, Sanchez-Pena LC, De Vizcaya-Ruiz A, Del Razo LM. Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite. Toxicol Lett. 2006;160(2):135–42.

    Article  CAS  Google Scholar 

  10. Wu MM, Chiou HY, Ho IC, Chen CJ, Lee TC. Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects. Environ Health Perspect. 2003;111(11):1429–38.

    Article  CAS  Google Scholar 

  11. Yu HS, Liao WT, Chang KL, Yu CL, Chen GS. Arsenic induces tumor necrosis factor alpha release and tumor necrosis factor receptor 1 signaling in T helper cell apoptosis. J Invest Dermatol. 2002;119(4):812–9.

    Article  CAS  Google Scholar 

  12. Wauson EM, Langan AS, Vorce RL. Sodium arsenite inhibits and reverses expression of adipogenic and fat cell-specific genes during in vitro adipogenesis. Toxicol Sci. 2002;65(2):211–9.

    Article  CAS  Google Scholar 

  13. Park SK, Peng Q, Bielak LF, Silver KD, Peyser PA, Mitchell BD. Arsenic exposure is associated with diminished insulin sensitivity in non-diabetic Amish adults. Diabetes Metab Res Rev. 2016;32(6):565–71.

    Article  CAS  Google Scholar 

  14. Mondal V, Hosen Z, Hossen F, Siddique AE, Tony SR, Islam Z, et al. Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass. Environ Int. 2020;143:105890.

    Article  CAS  Google Scholar 

  15. Diaz-Villasenor A, Cruz L, Cebrian A, Hernandez-Ramirez RU, Hiriart M, Garcia-Vargas G, et al. Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: a pilot study of risk factors for T2DM. PLoS One. 2013;8(1):e51642.

    Article  CAS  Google Scholar 

  16. Baek K, Lee N, Chung I. Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans: data from the fourth Korea National Health and nutrition examination survey (KNHANES) 2008-2009. Ann Occup Environ Med. 2017;29:31.

    Article  Google Scholar 

  17. Wang X, Mukherjee B, Karvonen-Gutierrez CA, Herman WH, Batterman S, Harlow SD, et al. Urinary metal mixtures and longitudinal changes in glucose homeostasis: the study of Women's health across the nation (SWAN). Environ Int. 2020;145:106109.

    Article  CAS  Google Scholar 

  18. Ashley-Martin J, Dodds L, Arbuckle TE, Bouchard MF, Shapiro GD, Fisher M, et al. Association between maternal urinary speciated arsenic concentrations and gestational diabetes in a cohort of Canadian women. Environ Int. 2018;121(Pt 1):714–20.

    Article  CAS  Google Scholar 

  19. Ettinger AS, Zota AR, Amarasiriwardena CJ, Hopkins MR, Schwartz J, Hu H, et al. Maternal arsenic exposure and impaired glucose tolerance during pregnancy. Environ Health Perspect. 2009;117(7):1059–64.

    Article  CAS  Google Scholar 

  20. Farzan SF, Gossai A, Chen Y, Chasan-Taber L, Baker E, Karagas M. Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study. Environ Health. 2016;15(1):106.

    Article  Google Scholar 

  21. Marie C, Leger S, Guttmann A, Riviere O, Marchiset N, Lemery D, et al. Exposure to arsenic in tap water and gestational diabetes: a French semi-ecological study. Environ Res. 2018;161:248–55.

    Article  CAS  Google Scholar 

  22. Munoz MP, Valdes M, Munoz-Quezada MT, Lucero B, Rubilar P, Pino P, et al. Urinary inorganic arsenic concentration and gestational diabetes mellitus in pregnant women from Arica, Chile. Int J Environ Res Public Health. 2018;15(7).

  23. Peng Q, Harlow SD, Park SK. Urinary arsenic and insulin resistance in US adolescents. Int J Hyg Environ Health. 2015;218(4):407–13.

    Article  CAS  Google Scholar 

  24. Shapiro GD, Dodds L, Arbuckle TE, Ashley-Martin J, Fraser W, Fisher M, et al. Exposure to phthalates, bisphenol a and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: the MIREC study. Environ Int. 2015;83:63–71.

    Article  CAS  Google Scholar 

  25. Wang Y, Zhang P, Chen X, Wu W, Feng Y, Yang H, et al. Multiple metal concentrations and gestational diabetes mellitus in Taiyuan, China. Chemosphere. 2019;237:124412.

    Article  CAS  Google Scholar 

  26. Xia X, Liang C, Sheng J, Yan S, Huang K, Li Z, et al. Association between serum arsenic levels and gestational diabetes mellitus: a population-based birth cohort study. Environ Pollut. 2018;235:850–6.

    Article  CAS  Google Scholar 

  27. Mazumdar M. Does arsenic increase the risk of neural tube defects among a highly exposed population? A new case-control study in Bangladesh. Birth Defects Res. 2017;109(2):92–8.

    Article  CAS  Google Scholar 

  28. Ahmad SA, Khan MH, Haque M. Arsenic contamination in groundwater in Bangladesh: implications and challenges for healthcare policy. Risk Manag Healthc Policy. 2018;11:251–61.

    Article  Google Scholar 

  29. Chakraborti D, Rahman MM, Das B, Murrill M, Dey S, Chandra Mukherjee S, et al. Status of groundwater arsenic contamination in Bangladesh: a 14-year study report. Water Res. 2010;44(19):5789–802.

    Article  CAS  Google Scholar 

  30. Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, et al. Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh. Environ Health. 2015;14:34.

    Article  Google Scholar 

  31. Punshon T, Li Z, Marsit CJ, Jackson BP, Baker ER, Karagas MR. Placental metal concentrations in relation to maternal and infant toenails in a U.S. Cohort. Environ Sci Technol. 2016;50(3):1587–94.

    Article  CAS  Google Scholar 

  32. Franson MAH, Clesceri LS, Eaton AD, Greenberg AE. American Public health a, American water works a, water environment F: standard methods for the examination of water and wastewater, 19th ed. Washington, DC: American Public Health Association; 1996.

    Google Scholar 

  33. Chen Y, Ahsan H, Parvez F, Howe GR. Validity of a food-frequency questionnaire for a large prospective cohort study in Bangladesh. Br J Nutr. 2004;92(5):851–9.

    Article  CAS  Google Scholar 

  34. Al-Rmalli SW, Jenkins RO, Haris PI. Betel quid chewing elevates human exposure to arsenic, cadmium and lead. J Hazard Mater. 2011;190(1-3):69–74.

    Article  CAS  Google Scholar 

  35. Ettinger AS, Arbuckle TE, Fisher M, Liang CL, Davis K, Cirtiu CM, et al. Arsenic levels among pregnant women and newborns in Canada: results from the maternal-infant research on environmental chemicals (MIREC) cohort. Environ Res. 2017;153:8–16.

    Article  CAS  Google Scholar 

  36. Kile ML, Houseman EA, Breton CV, Smith T, Quamruzzaman Q, Rahman M, et al. Dietary arsenic exposure in Bangladesh. Environ Health Perspect. 2007;115(6):889–93.

    Article  CAS  Google Scholar 

  37. Taylor V, Goodale B, Raab A, Schwerdtle T, Reimer K, Conklin S, et al. Human exposure to organic arsenic species from seafood. Sci Total Environ. 2017;580:266–82.

    Article  CAS  Google Scholar 

  38. Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy. Diabetes Care. 2010;33(8):1798–804.

    Article  CAS  Google Scholar 

  39. Walsh CH, O'Regan J, O'Sullivan DJ. Effect of different periods of fasting on oral glucose tolerance. Br Med J. 1973;2(5868):691–3.

    Article  CAS  Google Scholar 

  40. Galtier F. Definition, epidemiology, risk factors. Diabetes Metab. 2010;36(6 Pt 2):628–51.

    Article  CAS  Google Scholar 

  41. Karagas MR, Tosteson TD, Blum J, Klaue B, Weiss JE, Stannard V, et al. Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. Am J Epidemiol. 2000;152(1):84–90.

    Article  CAS  Google Scholar 

  42. T R. Arsenic. Hagerstown: Lippincott Williams & Wilkins; 2007.

    Google Scholar 

  43. Bonaventura MM, Bourguignon NS, Bizzozzero M, Rodriguez D, Ventura C, Cocca C, et al. Arsenite in drinking water produces glucose intolerance in pregnant rats and their female offspring. Food Chem Toxicol. 2017;100:207–16.

    Article  CAS  Google Scholar 

  44. Carmean CM, Kirkley AG, Landeche M, Ye H, Chellan B, Aldirawi H, et al. Arsenic exposure decreases adiposity during high-fat feeding. Obesity (Silver Spring). 2020;28(5):932–41.

    Article  CAS  Google Scholar 

  45. Liu S, Guo X, Wu B, Yu H, Zhang X, Li M. Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice. Sci Rep. 2014;4:6894.

    Article  CAS  Google Scholar 

  46. Gong Y, Liu J, Xue Y, Zhuang Z, Qian S, Zhou W, et al. Non-monotonic dose-response effects of arsenic on glucose metabolism. Toxicol Appl Pharmacol. 2019;377:114605.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Shravanthi Seshasayee, Lisa Rokoff, and Jessica Young for assistance with the statistical analysis.

Funding

The authors have received support from the National Institutes of Health (R01 ES026317, R01 ES027825, P30 ES000002, P50 HD10531 and R01 ES030101).

Author information

Authors and Affiliations

  1. Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA

    Abby F. Fleisch

  2. Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA

    Abby F. Fleisch

  3. Department of Paediatric Neurosurgery, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh

    Sudipta Kumer Mukherjee, Sheikh Muhammad Ekramullah, D. M. Arman & Joynul Islam

  4. Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

    Subrata K. Biswas

  5. Department of Neurology, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA, 02115, USA

    John F. Obrycki & Maitreyi Mazumdar

  6. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA

    David C. Christiani

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Contributions

MM, AF, SKM, SME, DMA, and JI conceived the study. SKB performed biochemical analyses. JO performed the statistical analyses. AFF drafted the manuscript. AFF, JO, DC, SKM, and MM contributed to the interpretation of data and provided critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Maitreyi Mazumdar.

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Ethics approval and consent to participate

All women provided written consent, and the Human Research Committees at Boston Children’s Hospital (BCH), NINS, and the Bangladesh Medical Research Committee approved the study.

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Not applicable.

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The authors declare that they have no competing interests.

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Fleisch, A.F., Mukherjee, S.K., Biswas, S.K. et al. Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh. Environ Health 21, 13 (2022). https://doi.org/10.1186/s12940-021-00811-1

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  • DOI: https://doi.org/10.1186/s12940-021-00811-1

Keywords

  • Pregnancy
  • Arsenic
  • Postpartum
  • Insulin resistance
  • Beta cell function
  • Bangladesh

Environmental Health

ISSN: 1476-069X