 Research
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 Published:
Quantifying the shortterm effects of air pollution on health in the presence of exposure measurement error: a simulation study of multipollutant model results
Environmental Health volume 20, Article number: 94 (2021)
Abstract
Background
Most epidemiological studies estimate associations without considering exposure measurement error. While some studies have estimated the impact of error in singleexposure models we aimed to quantify the effect of measurement error in multiexposure models, specifically in timeseries analysis of PM_{2.5}, NO_{2}, and mortality using simulations, under various plausible scenarios for exposure errors. Measurement error in multiexposure models can lead to effect transfer where the effect estimate is overestimated for the pollutant estimated with more error to the one estimated with less error. This complicates interpretation of the independent effects of different pollutants and thus the relative importance of reducing their concentrations in air pollution policy.
Methods
Measurement error was defined as the difference between ambient concentrations and personal exposure from outdoor sources. Simulation inputs for error magnitude and variability were informed by the literature. Errorfree exposures with their consequent health outcome and errorprone exposures of various error types (classical/Berkson) were generated. Bias was quantified as the relative difference in effect estimates of the errorfree and errorprone exposures.
Results
Mortality effect estimates were generally underestimated with greater bias observed when low ratios of the true exposure variance over the error variance were assumed (27.4% underestimation for NO_{2}). Higher ratios resulted in smaller, but still substantial bias (up to 19% for both pollutants). Effect transfer was observed indicating that less precise measurements for one pollutant (NO_{2}) yield more bias, while the copollutant (PM_{2.5}) associations were found closer to the true. Interestingly, the sum of singlepollutant model effect estimates was found closer to the summed true associations than those from multipollutant models, due to cancelling out of confounding and measurement error bias.
Conclusions
Our simulation study indicated an underestimation of true independent health effects of multiple exposures due to measurement error. Using error parameter information in future epidemiological studies should provide more accurate concentrationresponse functions.
Introduction
Air pollution is the major environmental factor affecting human health [1, 2]. Many publications report associations of morbidity and mortality outcomes with exposure to air pollutants, such as PM_{2.5}, NO_{2} and O_{3} [3, 4]. It is important to assess the independent effects of each pollutant adjusting for potential confounding by other pollutants in the mixture, as policies to reduce emissions differ by targeted pollutant. Multipollutant models are the most commonly used method, and, if correctly specified, provide estimates of the independent effects of each exposure [5,6,7].
Most studies addressing the associations between pollutants and health, or performing health impact assessments (HIA), do not account for exposure measurement error (ME), although it is a wellknown problem [8,9,10,11]. ME may lead to biased concentrationresponse functions (CRFs) for which the magnitude and type of bias is not assessed or corrected. While the methodology to correct for ME is expanding, there is a gap between theory and practice [12, 13]. To evaluate ME we must define the “gold standard” against which “proxy” measures are compared. For exposure to ambient concentrations, the most appropriate gold standard is individual exposure to ambient sources of the pollutant of interest. However, most epidemiological studies investigating ME in air pollution exposure, measure total personal exposure, to which indoor and personallygenerated sources contribute substantially [14].
An appropriate framework describing the types of error for exposure variables has not been discussed thoroughly in the literature. Zeger et al. (2000) mention that “classical and Berkson models represent two extremes of a continuum”, so the proper model combines elements of each type [9]. Few studies have examined the impact of mixture error [15,16,17]. Previous studies examining the impact of ME in regression models either only used singlepollutant models or addressed only spatial heterogeneity of the pollutants and their errors or have made specific assumptions for their error definition using empirical data from certain locations which might not be generalisable [18,19,20,21,22,23]. Multipollutant models, in addition, provide unstable estimates because of the complex relationships between pollutants, both in space and time, and the differing degree and structure of their errors  especially the variability and correlation between errors.
In our study, we focus on multipollutant models using a mixture error model of classical and Berkson components based on the error decomposition of Zeger and colleagues (2000). The percentages of each type depend on the pollutant under investigation, i.e. fine particulate matter, PM_{2.5}, or nitrogen dioxide, NO_{2}. We used simulated data to generate a wide range of plausible scenarios of the pollutant errors under a mixture error model, and to quantify the real impact of ME on the multipollutant model effect estimates, specifically in timeseries analysis.
Methods
Simulation setup
We previously conducted a systematic review on the differences between ambient concentrations and personal exposures from outdoor origins to inform our simulation inputs and quantify the magnitude and variability of the pollutant errors [24]. In particular, we created a simulated daily timeseries for errorfree (A) and errorprone (C) exposures and a health outcome over a period of 4 years, under various scenarios for factors that drive ME bias (Fig. S1, Supplementary material). Our focus was only on the quantification of exposure measurement error bias, so we did not include some features of timeseries that may introduce other forms of bias and need to be taken into account in real data analysis, such as autocorrelation, trends or confounders measured with error.
Each scenario was created as a combination of key parameters driving ME bias, i.e. the correlation between the exposures, the error variability (\( SD\left({\delta}_{P{M}_{2.5}}\right) \), \( SD\left({\delta}_{NO_2}\right) \)) and the true exposure variance/error variance ratio (\( SD\left({A}_{P{M}_{2.5}}\right)/ SD\left({\delta}_{P{M}_{2.5}}\right), SD\left({A}_{NO_2}\right)/ SD\left({\delta}_{NO_2}\right) \)) [23]. The latter was informed according to data from three different areas, for which we had adequate information [24]. In total, 144 scenarios were investigated, and their inputs are summarised in Figure 1. Due to space constraints, we expanded only one branch in the tree plot (in bold); this was assumed to be the core scenario compared with which all sensitivity analyses were performed. For each scenario, 1000 simulated datasets were generated.
Briefly, we assumed:

Variance ratios: We created scenarios separately for Europe, Eastern and Western North America which correspond to different ratios of the true exposure variance over the error variance. Differences in the ratios between these regions can be attributed to various factors, such as the use of Diesel vehicles, air conditioning, and legislation [25].

Correlation between the exposures: To the best of our knowledge, no data for the correlation between personal exposures from outdoor sources to PM_{2.5} and NO_{2} are reported in the literature. Thus, we assumed that it lies between published correlation coefficients of total personal exposures and correlations of the ambient measurements for the same pollutants [26,27,28]. A range of values was hypothesized to cover various plausible scenarios.

Correlations between the errors: Because we did not have real data to estimate the relationship between these errors, an analytical approach for their covariance was applied using the pairwise associations of personal and ambient concentrations for NO_{2} and PM_{2.5} (eq. 2).

Error structures: Little is known about the distributions and types of exposure ME. We assumed that the errors are additive on the logarithmic scale [29, 30]. Moreover, we assumed that a mixture of classical and Berkson error best describes the type of exposure misclassification [9]. However, scenarios of entirely classical and entirely Berkson error, alternative figures for the classicalBerkson ratio and multiplicative error were also assessed.
Input data
The key input parameters are summarised in Table 1. We assumed different “true” exposures and error variability for each study area which resulted in different exposure variance over error variance ratios. Three correlation coefficients between the exposures (low = 0.25/moderate = 0.5/high = 0.75) and four values for the error variability for each pollutant were hypothesized. For example, for Europe (core scenario) we hypothesized moderate error variability (5.2 μg/m^{3} for PM_{2.5} and 6.2 ppb for NO_{2}), very low (0.5 μg/m^{3} and 0.6 ppb respectively (0.1 × moderate)), low (2.6 μg/m^{3} and 3.1 ppb respectively (0.5 × moderate)), and high (6.8 μg/m^{3} and 8.1 ppb respectively (1.3 × moderate)). The 144 scenarios tested derived from all the possible combinations of these parameters.
Generating "errorfree" or "true" exposures (A):
We used a bivariate lognormal distribution to generate 1461 daily measurements of the “errorfree” exposures for each scenario s, as follows:
where μ_{s} is the vector of pollutant means, Σ_{s} the variancecovariance matrix and 1, 2 = NO_{2} and PM_{2.5}, respectively. For example, for the European area, we had:
Generating “errorprone” or “apparent” exposures (C):
We considered a mixture of classical and Berkson ME additive on the logarithmic scale as the most appropriate model because the sources of error can originate from both classical error (omitting individuals’ mobility, the infiltration efficiency of the buildings, and instrument errors) and Berkson error from unincorporated spatial heterogeneity [9]. Various scenarios for the errors allowed evaluation of how the error type affects the health effect estimates, especially in twopollutant models where the magnitude and direction of bias cannot easily be predicted in typical epidemiologic studies without specifically investigating ME.
Classical error
Apparent exposures of classical error were generated simply by adding random error to the assumed true exposures. For this type of error, we have:
where i is NO_{2} or PM_{2.5}, t is day, t = 1,2, …, 1461, C and A are as defined above, and the errors, δ, of the pollutants were created from a bivariate normal distribution:
The elements in the diagonal of Σ are the error variances as estimated from [24]. The covariance was estimated analytically:
There was no information in the literature for the associations between C and A, so we used covariances from studies of total personal exposure instead [26,27,28].
Berkson error
In general, a Berkson error model can be described as follows:
We used a formula to generate Berkson error proposed by Carroll et al. (2006) [11]. Briefly, if C = A + δ (i.e. classical model) we know that the best linear predictor of A given C is (1λ)∙E(A) + λ∙C, where \( \lambda =\frac{\sigma_C^2}{\sigma_C^2+{\sigma}_{\delta}^2} \). Then, the following equation (4) results in the generation of a Berksoniantype errorprone exposure. For simplicity, we omitted the indicators i, t:
where \( {\delta}^{\ast}\sim N\left(0,\frac{\sigma_C^2\bullet {\sigma}_{\delta}^2}{\sigma_C^2+{\sigma}_{\delta}^2}\right) \) and \( {\sigma}_{\delta}^2 \) is the error variance (Supplementary material).
Mixture error
Using the error decomposition from Zeger and colleagues [9], with data from other studies [31, 32], we quantified the errorprone variables of the mixture type. We estimated the error as 43% classical and 57% Berkson for PM_{2.5} and 33% classical and 67% Berkson for NO_{2} in the main analysis, while in sensitivity analyses we assumed increased percentages of classical error for both pollutants, i.e. either (55,45%) for PM_{2.5} and (45,55%) for NO_{2} or (70,30%) for PM_{2.5} and (60,40%) for NO_{2}. As the hypothesized true exposures are lognormally distributed, we assumed additive error on the logscale for the ME models based on previous studies, but also applied a multiplicative approach [29, 30].
The mixture model consists of the variables described in eqs. 1 and 2, along with a latent intermediate variable L, between A and C, that allows for mixtures of Berkson and classical error as described elsewhere [15, 33]. Briefly, the model is:
where δ_{b}, δ_{c} denote Berksontype and classicaltype error (Supplementary material).
Generating allcause mortality
For each day t, the number of deaths Y_{t} was assumed to follow a Poisson distribution with overdispersion φ. The mean μ_{t} of the Poisson distribution was created to be dependent only on the simulated “true” concentrations of both pollutants on every particular day as follows:
where \( {A}_{N{O}_2}^t,{A}_{P{M}_{2.5}}^t \) are the daily concentrations for NO_{2} and PM_{2.5}, respectively.
To simulate this Poisson overdispersed data, we assumed that daily mortality followed a Negative Binomial distribution, NB (μ_{t},θ), where μ_{t} is the mean daily number of deaths, and θ = φ/(μ_{t}1). To get reasonable estimates for β_{0}, φ we used real mortality and air pollution data during 2011–2014 in Greater London.
For the selection of β_{1}, β_{2} we reviewed the literature for studies that reported associations between shortterm exposure to NO_{2} and PM_{2.5} and allcause mortality and derived their CRFs. We chose plausible CRF values from a recent metaanalysis of time series studies despite the fact that they are not adjusted for ME, i.e. a 0.6 and 0.54% increase in allcause mortality per 10 units increase in NO_{2} and PM_{2.5} respectively (β_{1} = 0.0006, β_{2} = 0.00054) [34]. We also tested whether the results remain unchanged when the true coefficients were assumed to be half or twice the above percentage increases or when only one pollutant had a true health effect (β_{i} = 0 for the copollutant).
Epidemiological analysis
In the context of this study, we are interested in the ME bias  quantified as the difference between the health effect estimates of errorfree and errorprone exposures. The Poisson timeseries model allowing for overdispersion used in every iteration was:
where Y_{t} is the death count for day t and \( {C}_{N{O}_2}^t \), \( {C}_{P{M}_{2.5}}^t \) the corresponding errorprone exposure based on every scenario. We also calculated coverage probability as the percentage of 95% confidence intervals that include the assumed true exposureresponse association, and power as the percentage of statistically significant estimates at the 5% level.
Results
We confirmed that the generated exposure variables had close to the expected mean values (Table 1) and the expected distributions for the classical, Berkson or mixed error types (Fig. S2, Supplementary Material).
Table 2 contains the average Poisson regression estimates across all scenarios by areas under investigation. Pure Berkson error model resulted in overestimation of the true mortality effect for all areas and pollutants by 1.5 to 8.2%, except for the NO_{2} coefficient for Europe (a decrease of 7.9%), the assumed area scenario with the lower exposure variance/error variance ratio and higher corresponding ratio for the coexposure. Otherwise, the mortality effects were underestimated with greater bias observed in Europe for NO_{2} (27.4%, mixture model). Interestingly, the bias in North America was similar for both pollutants, around 15–19% for classical error and 9–13% for mixture (area scenarios with similar, and relatively low exposure variance/error variance ratios for both pollutants). In Europe, the bias was significantly increased for NO_{2} compared with PM_{2.5}, 10.0 and 25.1% for classical and 1.3 and 27.4% for mixture error respectively. Coverage and power for both pollutants across all scenarios by area and error type were 51–60% and 60–80% respectively.
The results of mixture error are illustrated in Fig. 2 showing the relationship between PM_{2.5} and NO_{2} coefficients by study area for all scenarios. No scenario resulted in overestimation of the effect of both pollutants (upper right quartile). Between pollutants, higher values of \( {\hat{\beta}}_1 \) tend to be associated with lower values of \( {\hat{\beta}}_2 \), in an approximate quadratic negative relationship. No clear pattern was observed by study area, except for a group of European results in the lower right of the graph (> 70% decrease in the NO_{2} effect estimate). NO_{2} coefficient attenuation is higher than in other scenarios because the hypothesized exposure variance/error variance ratio was lower compared to PM_{2.5}.
Figure 3 plots the mortality estimates for both pollutants sorted in increasing order of NO_{2} effect size (left). Effect transfer can clearly be observed either from NO_{2} to PM_{2.5} (upper part) or from PM_{2.5} to NO_{2} (lower part), but also, there are some scenarios where both coefficients were attenuated (middle part). Interestingly, in the middle and even at the top of the graph, there are scenarios in which the estimates for both pollutants are to the left of the true beta line i.e. attenuated. Nonetheless, large attenuations for both pollutant estimates did not occur simultaneously, as can be seen from the absence of points in the bottom left corner of Fig. 2.
Table 3 illustrates the model estimates with different assumed values for the correlation between the exposures and the error variances. Results from the most plausible error model are reported, i.e. mixture error. Effect transfer is clearly observed, as the effect estimates for one exposure are decreasing when its error variability is increasing (less precise exposure), while the coexposure’s coefficients are increasing, and its error variability is kept fixed. For example, in the “moderate” correlation scenarios, keeping the PM_{2.5} error variability fixed at “low” (SD(\( {\delta}_{P{M}_{2.5}} \)) = 2.9 μg/m^{3}), the bias in the PM_{2.5} Poisson regression estimates range from − 3.7% in the “very low” NO_{2} error variability scenario to + 17.8% in the “high” scenario. On the contrary, the corresponding bias for NO_{2} varies from + 0.7% to − 50.0% (“very low” to “high” SD(\( {\delta}_{NO_2} \))). Bias in the effect estimates varies highly by assumed error structure from 26.1% overestimation to 44.0% underestimation of the true effect for PM_{2.5}, and from + 12.1% to − 58.4% for NO_{2}. The highest biases are observed in the most extreme scenarios, but in the more plausible “low”“moderate” error variability scenarios, bias is not negligible (values up to approximately 30% towards the null). Correlation between the exposures does not seem to be a driving factor for the bias.
Comparing multi and singlepollutant model coefficients (β_{M} and β_{S} respectively), Table 4 suggests that, in the absence of ME, using β_{S} may result in a large overestimation of the combined effect of PM_{2.5} and NO_{2}. Thus, β_{S}, in general, includes effects attributable to both pollutants where both pollutants have a true effect on mortality. For mixture error, regression coefficients increased by 22.5% for PM_{2.5} and 17.7% for NO_{2}, when single instead of multipollutant models were fitted. Surprisingly, the combined effect, \( {\beta}_{S_1}+{\beta}_{S_2} \), of the mixture errorprone variables was closer to the true combined effect, i.e. 5.4 + 6.0, compared to \( {\beta}_{M_1}+{\beta}_{M_2} \). No significant differences were observed between the standard errors of β_{M} and β_{S}.
We performed sensitivity analyses with the Europe, additive, mixture error, core scenario to check which of the simulation inputs are driving ME bias. No difference in the relative bias was observed when we assumed a “true” CRF half or twice the core one. Mortality estimates were attenuated even more when only one pollutant had a true effect on health compared to the case where both had an effect. Interestingly, effect transfer is observed from the pollutant with the true effect to the copollutant assumed to have no true effect. When the classical part in the error mixture was increased for both pollutants, the relative bias increased for PM_{2.5} (from 1.3 to 6.0%), while it only decreased slightly for NO_{2} (from 27.4 to 25.4%). Finally, multiplicative error resulted in great underestimation of the exposureresponse relationship, i.e. 84.5 and 90.0% for PM_{2.5} and NO_{2} respectively (Table 5).
Discussion
We performed a simulation study to quantify the bias in mortality effect estimates caused by ME in multipollutant, timeseries models including PM_{2.5} and NO_{2}. While the impact of ME can be more easily predicted when single exposures are measured with error, multiple errorprone exposures of any error type (i.e. purely classical, purely Berkson or mixture) can distort the health effect estimates. Our results can be applied to other outcomes and exposures as well.
Mixture error model was found to attenuate the effect of both pollutants, with higher attenuation for NO_{2}, the exposure variable measured with more error as found previously [24]. ME also reduced coverage of 95% confidence intervals and statistical power. The largest underestimations of the true effect were in North America for PM_{2.5} (10.3%) and in European studies for NO_{2} (27.4%). Differences by study area were observed because of the different pollutant variability/error variability ratios in these areas and/or potentially other unobserved parameters related to ME. For example, the exposure assessment method used (e.g. measured or modelled concentrations) and the exposure metric (e.g. 24h mean/max, ambient or personal exposure) may vary by study area. When various values for the correlation between the exposures were assessed, mortality estimates did not change significantly. This is important because correlation between pollutant concentrations is the most common factor discussed in air pollution epidemiological studies as driving unreliability in multipollutant models. Day et al. (2004) have reached to similar conclusions for the correlations between the exposures and between the errors except for the case of high correlations (both > 0.8), for a nutritional epidemiology study context [35]. No change was observed in the relative bias with different “true” CRFs, while a small, false positive effect was observed for the pollutant assumed to have no true effect, when both exposures are measured with error. In contrast, when we assumed multiplicative instead of additive error (i.e. a less likely scenario), both pollutant health effect estimates were > 85% biased. Finally, only the PM effect estimate underestimation increased when varying the classicalBerkson ratio of the mixture.
Effect transfer was clearly observed concluding that less precise measurements for one pollutant yield more bias while the copollutant effect estimates were closer to the true. This decrease in the bias of the copollutant, however, can be regarded as due to the net effect of underestimation due to ME and overestimation due to effect transfer; the latter cancelling out the effect of the former. Szpiro et al. (2011) showed in their simulation study that more accurate exposure predictions do not necessarily improve the health effect estimates [22]. They considered the effects of longterm exposure to air pollution and on comparisons between exposures from correctly specified and misspecified prediction models. However, similar approaches in a multipollutant framework have shown that measurement error bias can be severe and correcting for it can strengthen the exposureresponse associations [36]. Timeseries studies showed that health effect estimates from modelled data are more prone to ME than from measured concentrations [37]. Goldman et al. (2011) reported that spatial error, (only a part of our error decomposition), attenuated the risk ratios from 19 to 31% for primary pollutants (including NO_{2}), but only from 2 to 9% for secondary pollutants (PM_{2.5} regarded as such) [30]. These values are close to our overall bias estimates of 17 and 7% respectively, even though their characterisation of NO_{2} and PM_{2.5} as primary and secondary pollutants respectively might be questionable. Similarly, Dionisio et al. (2016) fitting twopollutant timeseries models with additive and multiplicative error reported total effect attenuation up to 85% for NO_{2} (close to our estimates for multiplicative error), indicating multipollutant model estimates are even more susceptible to ME [38]. Blangiardo et al. (2019) also found, under a Bayesian framework, that NO_{2} effects were considerably biased when errorprone concentrations were used [39]. However, they focused on collinearity in multipollutant models without assessing error structures/types.
When misspecified singlepollutant models were fitted, increased effect estimates were observed compared to twopollutant model coefficients. Interestingly, with mixture errorprone variables, the sum of the singlepollutant model effect estimates was closer to the true combined effect compared with the corresponding sum from multipollutant models (due to an accidental cancelling out of overestimation in singlepollutant models from confounding by the copollutant and underestimation due to ME). These conclusions hold only when the pollutants are positively correlated. Hence, even if it is accepted that both pollutants have a true causal effect on health [40], should single or multipollutant models be used for quantifying the combined effects of air pollution? Clearly, multipollutant models take into account the confounding effects between the pollutants, but if ME is disregarded, biased estimates are produced. This implies that in a “multipollutant air quality management framework”, ME correction methods should not be neglected [41]. If a correction method cannot be applied, singlepollutant model effects may not be significantly overestimated, but this might only hold under some conditions (e.g. specific correlations between pollutants and/or between errors).
Several previous studies have considered the effects of a mixture of classical and Berkson error in exposures other than air pollution. Mallick et al. (2002) found that the mixture error bias in their relative risks for thyroid disease and radiation fallout ranged from 3.2 to 42.7% [15]. Tapsoba et al. (2019) studying medications in HIV patients report biases from 0 to 22% depending on the correction method [33]. These values are close to our findings, as is their assumed percentage of Berkson error in the exposure that lies between 20 and 80%. In contrast, Deffner et al. (2018), examining the effects of ultrafine particles on heart rate, reported that mixture error had little impact on their results [17]. This, however, may be due to their error definitions: they assumed that total personal measurements include only classical error, measurements from fixed sites only Berkson.
This simulation study has some limitations. Firstly, several of our assumptions increased the uncertainty of our estimates. For example, we used pooled estimates for the error structures across wide study areas (e.g. cities within our areas may have different concentrations), and approximations for the correlation between exposures and between errors. However, to the best of our knowledge, no study has attempted to quantify the important error variables in specific areas, apart from Dionisio et al. (2014) in Atlanta (using a different, more spatial framework than our study) [23]. We used more generalisable inputs provided from previously published work [24]. In addition, equal exposure misclassification across days was assumed, increasing the uncertainty about the relationship between sources of spatial and temporal variations. We could not investigate the dependency or correlation between daily exposures and how this might interact with the spatial variation. Moreover, we assumed a constant percent error model additive on the logarithmic scale which implies that at low exposures, error is also low, and vice versa. Error may be higher at high exposures, but it might not drop substantially at lower concentrations. In future work, we plan to use real data from panel studies to identify the gaps in our information and describe properly the error structures of the air pollutants.
This study discusses PM_{2.5} and NO_{2} and how to separate their effects on health. There is debate over whether NO_{2} is acting as an indicator for other traffic pollutants. To the extent that these other pollutants have similar spatial error characteristics and some, e.g. CO, ultrafine particles, may also have greater infiltration indoors than PM_{2.5}, our findings regarding effect transfer in multipollutant models with PM_{2.5} will also apply. Moreover, our work could not quantify the error structures of ozone so could not assess its exposure misclassification bias. This work was on two pollutants that are generally positively correlated. Ozone, due to its formation and characteristics, can be negatively correlated with PM_{2.5} and NO_{2}, and this may change our conclusions. However, the correlations are not expected to be very high, and according to this and previous studies, the effect of pollutant correlations on ME bias is not expected to be substantial [35]. We are currently working on this, using previously analysed raw data from a panel study on schoolchildren [42]. We will also assess the impact of ME on the shape of the exposureresponse curve. This work did not find any significant distortions for the shape of the CRFs for the health effects of shortterm exposures when the error is additive, but the effects of multiplicative error might be more profound especially for the identification of the longterm effects of air pollution, for which the CRFs are used in costbenefit analyses [43]. We addressed effect estimates from shortterm exposures. Future work should address the multipollutant model estimates for longterm exposures which may be more biased, as indicated in studies assessing singlepollutant exposures [31, 32]. Finally, measurement error correction is an important aspect which becomes more complex if we consider expanding the findings from exposure to air pollution to the whole exposome, i.e. the totality of environmental exposures throughout a lifetime. In such studies, variable selection methods are usually used, which rely on empirical data and may create false positive and false negative selections in the presence of ME [44].
In summary, this study quantified the effects of exposure measurement error on multipollutant, timeseries model estimates. Using simulations, under an extensive range of scenarios, we showed that nontrivial underestimation in health effect estimates can result from measurement error, especially for NO_{2}, which was found to be more prone to error, but for PM_{2.5} as well. We recommend that ME should be considered in every epidemiological analysis assessing exposures prone to large ME, and that studies of personal exposure should provide information on relevant error parameters, such as correlation between errors and error variability, in order to better understand the correct error structures of the pollutants. It is important that correct health effect estimates should be derived in order, not only to separate the independent effects of air pollutants, but also to correctly quantify the health impacts of air pollution, inform interpretation and recommend future approaches for policy making.
Availability of data and materials
The datasets used and analysed during the current study are available from the corresponding author on reasonable request. This work was produced using simulated data.
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Acknowledgements
We thank Professor Ruth Keogh (London School of Hygiene and Tropical Medicine) for her useful feedback in our analysis. We also thank our colleagues from Environmental Research Group (Imperial College London), Dr. Ben Barratt and Dr. David Green, for providing data used as simulation inputs.
Funding
This work was supported by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Health Impact of Environmental Hazards at King’s College London in partnership with Public Health England (PHE) and Imperial College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, the Department of Health & Social Care or Public Health England.
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DE: Statistical Methodology, Statistical Analysis, Writing  Original Draft, Review & Editing, KK: Conceptualisation, Statistical Methodology, Writing – Review & Editing, JS: Methodology, Writing – Review & Editing, HW: Conceptualisation, Statistical Methodology, Writing – Review & Editing, Supervision. All authors read and approved the final manuscript.
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Evangelopoulos, D., Katsouyanni, K., Schwartz, J. et al. Quantifying the shortterm effects of air pollution on health in the presence of exposure measurement error: a simulation study of multipollutant model results. Environ Health 20, 94 (2021). https://doi.org/10.1186/s12940021007574
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DOI: https://doi.org/10.1186/s12940021007574
Keywords
 Air pollution
 Measurement error
 Mixture error
 Effect transfer
 Simulations
 PM_{2,5}
 NO_{2}