DGS. Plan d’action chlordécone en Martinique et en Guadeloupe 2008–2010. Paris: Direction Générale de la Santé; 2008.
Google Scholar
DGS. Plan d’action chlordécone en Guadeloupe et en Martinique 2008–2010. Bilan par action 2010. Paris: Direction Générale de la Santé; 2011.
Google Scholar
DGS. Plan d’action contre la pollution par la chlordécone en Guadeloupe et en Martinique 2011–2013. Paris: Direction Générale de la Santé; 2011.
Google Scholar
InVS. Impact sanitaire de l’utilisation du chlordécone aux Antilles françaises Recommandations pour les recherches et les actions de santé publique. Saint Maurice: InVS, INSERM; 2009.
Google Scholar
Godard E, Guldner L. Évaluation et gestion du risque alimentaire associé au chlordécone pour les populations de Guadeloupe et de Martinique. Numéro thématique – Chlordécone aux Antilles : bilan actualisé des risques sanitaires BEH. 2011;3-4-5:34–6.
Google Scholar
AFSSA, AFSSA. Actualisation de l’exposition alimentaire au chlordécone de la population antillaise. Evaluation de l’impact de mesures de maîtrise des risques. final. Maisons-Alfort: Agence Française de Sécurité Sanitaire des Aliments; 2007.
Google Scholar
Larson PS, Egle Jr JL, Hennigar GR, Lane RW, Borzelleca JF. Acute, subchronic, and chronic toxicity of chlordecone. Toxicol Appl Pharmacol. 1979;48(1):29–41.
Article
CAS
Google Scholar
Guzelian PS. Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Annu Rev Pharmacol Toxicol. 1982;22:89–113. doi:10.1146/annurev.pa.22.040182.000513.
Article
CAS
Google Scholar
Guzelian PS. The clinical toxicology of chlordecone as an example of toxicological risk assessment for man. Toxicol Lett. 1992;64–65:589–96.
Article
Google Scholar
Sobel ES, Wang F, Butfiloski E, Croker B, Roberts SM. Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F (1) and BALB/c mice. Toxicology. 2006;218(2–3):81–9.
Article
CAS
Google Scholar
Multigner L, Ndong JR, Giusti A, Romana M, Delacroix-Maillard H, Cordier S, et al. Chlordecone exposure and risk of prostate cancer. J Clin Oncol. 2010;28(21):3457–62.
Article
CAS
Google Scholar
Dallaire R, Muckle G, Rouget F, Kadhel P, Bataille H, Guldner L, et al. Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone. Environ Res. 2012;118:79–85. doi:10.1016/j.envres.2012.07.006.
Article
CAS
Google Scholar
Boucher O, Simard MN, Muckle G, Rouget F, Kadhel P, Bataille H, et al. Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants. Neurotoxicology. 2013;35C:162–8. doi:10.1016/j.neuro.2013.01.007.
Article
CAS
Google Scholar
Multigner L, Kadhel P, Huc-Terki F, Thome JP, Janky E, Auger J. Exposure to Chlordecone and Male Fertility in Guadeloupe (French West Indies). Epidemiology. 2006;17(6):S372.
Article
Google Scholar
Multigner L, Kadhel P, Pascal M, Huc-Terki F, Kercret H, Massart C, et al. Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe. Environmental health: a global access science source. 2008;7:40. doi:10.1186/1476-069x-7-40.
Article
CAS
Google Scholar
Emeville E, Giton F, Giusti A, Oliva A, Fiet J, Thome JP, et al. Persistent organochlorine pollutants with endocrine activity and blood steroid hormone levels in middle-aged men. PLoS ONE. 2013;8(6), e66460. doi:10.1371/journal.pone.0066460.
Article
CAS
Google Scholar
ATSDR. Toxicological profile for mirex and chlordecone. Washington: Agency for Toxic Substances and Disease Registry. US Department of Health and Human Services; 1995.
Google Scholar
US-EPA. Toxicological review of chlordecone (Kepone). Washington: United States Environmental Agency; 2009.
Google Scholar
NCI. Report on carcinogenesis bioassay of technical grade chlordecone (Kepone) CAS No. 143-50-0: U.S. Department of health, education and welfare, Public Health Service, National Institut of Health. 1976.
Google Scholar
Guldner L, Multigner L, Heraud F, Monfort C, Thome JP, Giusti A, et al. Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone. Environ Res. 2010;110(2):146–51.
Article
CAS
Google Scholar
NRC. Science and decisions. Advancing Risk Assessment. Washington: The National Academies Press; 2009.
Google Scholar
Institute of Medicine. Cost of Environmental-Related Health Effects: A Plan for Continuing Study. Washington: The National Academies Press; 1981.
Google Scholar
Melnick R, Lucier G, Wolfe M, Hall R, Stancel G, Prins G, et al. Summary of the National Toxicology Program’s report of the endocrine disruptors low-dose peer review. Environ Health Perspect. 2002;110(4):427–31.
Article
CAS
Google Scholar
Cannon S, Veazey JJ, Jackson R, Burse V, Hayes C, Straub W, et al. Epidemic kepone poisoning in chemical workers. Am J Epidemiol. 1978;107(6):529–37.
Article
CAS
Google Scholar
Guzelian PS, Vranian G, Boylan JJ, Cohn WJ, Blanke RV. Liver structure and function in patients poisoned with chlordecone (Kepone). Gastroenterology. 1980;78(2):206–13.
CAS
Google Scholar
End DW, Carchman RA, Ameen R, Dewey WL. Inhibition of rat brain mitochondrial calcium transport by chlordecone. Toxicol Appl Pharmacol. 1979;51(1):189–96.
Article
CAS
Google Scholar
US-EPA. Guidelines for Carcinogen Risk Assessment. final. Washington: U.S. Environmental Protection Agency; 2005.
Google Scholar
Greenland S. Concepts and pitfalls in measuring and interpreting attributable fractions, prevented fractions, and causation probabilities. Ann Epidemiol. 2015;25(3):155–61. doi:10.1016/j.annepidem.2014.11.005.
Article
Google Scholar
Hill AB. The Environment and Disease: Association or Causation? Proceedings of the Royal Society of Medicine. 1965;58(5):295–300.
CAS
Google Scholar
US-EPA. Benchmark Dose Technical Guidance Document. Final. Washington: U.S. Environmental Protection Agency; 2012.
Google Scholar
US-EPA. Benchmark Dose Software (BMDS) v2.4.0. Washington: U.S. Environmental Protection Agency; 2013.
Google Scholar
The R Foundation. The R Project for Statistical Computing. https://www.r-project.org/
US-EPA. Recommended Use of Body Weight3/4 as the Default Method in Derivation of the Oral Reference Dose. Final. Washington: U.S. Environmental Protection Agency; 2011.
Google Scholar
US-EPA. Recommendations for and Documentation of Biological Values for Use in Risk Assessment. Washington: United States Environmental Agency; 1988.
Google Scholar
Nedellec V. Méthodes quantitatives pour évaluer les risques non mutagènes des substances chimiques. Application au cas du chlordécone. Paris: CNAM; 2015.
Google Scholar
Joly P-B. La saga du chlordécone aux Antilles françaises. Reconstruction chronologique 1968–2008. Document réalisé dans le cadre de l’action 39 du plan chlordécone Convention de collaboration AFSSET – INRA. final: INRA. 2010.
Google Scholar
Ganser GH, Hewett P. An accurate substitution method for analyzing censored data. J Occup Environ Hyg. 2010;7(4):233–44. doi:10.1080/15459621003609713.
Article
Google Scholar
Martinez AJ, Taylor JR, Dyck PJ, Houff SA, Isaacs E. Chlordecone intoxication in man. II. Ultrastructure of peripheral nerves and skeletal muscle. Neurology. 1978;28(7):631–5.
Article
CAS
Google Scholar
Taylor JR. Neurological manifestations in humans exposed to chlordecone and follow-up results. Neurotoxicology. 1982;3(2):9–16.
CAS
Google Scholar
Taylor JR. Neurological manifestations in humans exposed to chlordecone: follow-up results. Neurotoxicology. 1985;6(1):231–6.
CAS
Google Scholar
Taylor JR, Selhorst JB, Houff SA, Martinez AJ. Chlordecone intoxication in man. I. Clinical observations. Neurology. 1978;28(7):626–30.
Article
CAS
Google Scholar
Bolger R, Wiese TE, Ervin K, Nestich S, Checovich W. Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect. 1998;106:9.
Article
Google Scholar
Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 1998;139(10):4252–63.
CAS
Google Scholar
Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R. Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006;79(12):1160–9. doi:10.1016/j.lfs.2006.03.023.
Article
CAS
Google Scholar
Li Y, Luh CJ, Burns KA, Arao Y, Jiang Z, Teng CT, et al. Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect. 2013. doi:10.1289/ehp.1205951.
Google Scholar
Thomas P, Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol. 2006;102(1–5):175–9. doi:10.1016/j.jsbmb.2006.09.017.
Article
CAS
Google Scholar
Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. J Steroid Biochem Mol Biol. 2008;110(1–2):104–15. doi:10.1016/j.jsbmb.2008.02.008.
Article
CAS
Google Scholar
Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S. Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. J Steroid Biochem Mol Biol. 2001;78(1):25–32.
Article
CAS
Google Scholar
Yoon K, Pellaroni L, Ramamoorthy K, Gaido K, Safe S. Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Mol Cell Endocrinol. 2000;162(1–2):211–20.
Article
CAS
Google Scholar
Baggett J, Klein RL, Mehendale HM, Thureson-Klein AK. Acute kepone treatment of rats: a biochemical and ultrastructural study. Pharmacologist. 1977;19:2.
Google Scholar
Chambers JE, Trevathan CA. Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters. Toxicol Lett. 1983;16(1–2):109–15.
Article
CAS
Google Scholar
Curtis LR. Chlordecone is a potent in vitro inhibitor of oligomycin-insensitive Mg2 + − ATPase of rat bile canaliculi-enriched fraction. J Biochem Toxicol. 1988;3:321–8.
Article
CAS
Google Scholar
Curtis LR, Mehendale HM. Hepatobiliary dysfunction and inhibition of ATPase activity of bile canaliculi-enriched fractions following in vivo mirex, photomirex and chlordecone exposures. Toxicol Appl Pharmacol. 1981;61(3):429–40.
Article
CAS
Google Scholar
Desaiah D, Ho IK, Mehendale HM. Effects of kepone and mirex on mitochondrial Mg2 + −ATPase activity in rat liver. Toxicol Appl Pharmacol. 1977;39(2):219–28.
Article
CAS
Google Scholar
Desaiah D, Ho IK, Mehendale HM. Inhibition of mitochondrial Mg2+ ATPase activity in isolated perfused rat liver by kepone. Biochem Pharmacol. 1977;26(12):1155–9.
Article
CAS
Google Scholar
Eaton DL, Klaassen CD. Effects of 2,3,7,8- tetrachloro dibenzo-p- dioxin, Kepone, and poly brominated biphenyls on transport systems in isolated rat hepatocytes. Toxicol Appl Pharmacol. 1979;51(1):137–44.
Article
CAS
Google Scholar
Ebel RE. In Vitro Effects Of Chlordecone (Kepone) On Hepatic Microsomal Cytochrome P-450. Pestic Biochem Physiol. 1980;14(3):221–6.
Article
CAS
Google Scholar
Ebel RE. Alterations in microsomal cytochrome P-450-catalyzed reactions as a function of chlordecone (Kepone) induction. Pestic Biochem Physiol. 1982;18(1):113–21.
Article
CAS
Google Scholar
Fabacher DL, Hodgson E. Induction of hepatic mixed-function oxidase enzymes in adult and neonatal mice by kepone and mirex. Toxicol Appl Pharmacol. 1976;38(1):71–7.
Article
CAS
Google Scholar
Kaminsky LS, Piper LJ, McMartin DN, Fasco MJ. Induction of hepatic microsomal cytochrome P-450 by mirex and kepone. Toxicol Appl Pharmacol. 1978;43(2):327–38.
Article
CAS
Google Scholar
Kocarek TA, Schuetz EG, Guzelian PS. Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. Mol Pharmacol. 1991;40(2):203–10.
CAS
Google Scholar
Kocarek TA, Schuetz EG, Guzelian PS. Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel. Toxicol Lett. 1994;71(2):183–96.
Article
CAS
Google Scholar
Lamartiniere CA, Nicholas JM. Neonatal chlordecone alteration of the ontogeny of sex-differentiated hepatic drug and xenobiotic metabolizing enzymes. Biochem Pharmacol. 1984;33(24):4092–5.
Article
CAS
Google Scholar
Lee J, Scheri RC, Zhang Y, Curtis LR. Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice. Toxicol Appl Pharmacol. 2008;233(2):193–202.
Article
CAS
Google Scholar
Lewandowski M, Levi P, Hodgson E. Induction of cytochrome P-450 isozymes by mirex and chlordecone. J Biochem Toxicol. 1989;4(3):195–9.
Article
CAS
Google Scholar
Madhukar BV, Matsumura F. Comparison Of Induction Patterns Of Rat Hepatic Microsomal Mixed-Function Oxidases By Pesticides And Related Chemicals. Pestic Biochem Physiol. 1979;11:1–3.
Article
Google Scholar
Mehendale HM, Takanaka A, Desaiah D, Ho IK. Kepone induction of hepatic mixed function oxidases in the male rat. Life Sci. 1977;20(6):991–8.
Article
CAS
Google Scholar
Mehendale HM, Takanaka A, Desaiah D, Ho IK. Effect of preexposure to Kepone on hepatic mixed-function oxidases in the female rat. Toxicol Appl Pharmacol. 1978;44(1):171–89.
Article
CAS
Google Scholar
Simmons JE, Berman E, Jackson M, Lewtas J. In Vitro and In Vivo Toxicity: A Comparison of Acrylamide, Cyclophosphamide, Chlordecone, and Diethylstilbestrol. J Environ Sci Health Part A Environ Sci Eng. 1987;7:639–64.
Article
Google Scholar
Desaiah D, Koch RB. Inhibition of ATPases activity in channel catfish brain by Kepone and its reduction product. Bull Environ Contam Toxicol. 1975;13(2):153–8.
Article
CAS
Google Scholar
Folmar LC. In Vitro Inhibition Of Rat Brain ATPase, pNPPase, And ATP-32Pi Exchange By Chlorinated-Diphenyl Ethanes And Cyclodiene Insecticide. Bull Environ Contam Toxicol. 1978;19(4):481–8.
Article
CAS
Google Scholar
Doherty JD, Salem N, Lauter CJ, Trams EG. Mn2+ and Ca2+ ATPases in lobster axon plasma membranes and their inhibition by pesticides. Comp Biochem Physiol C. 1980;69(2):185–90.
Article
Google Scholar
Desaiah D, Gilliland T, Ho IK, Mehendale HM. Inhibition of mouse brain synaptosomal ATPases and ouabain binding by chlordecone. Toxicol Lett. 1980;6(4–5):275–85.
Article
CAS
Google Scholar
Desaiah D, Trottman CH. Sensitivity of rat brain synaptosomal ATPases to several structurally related organochlorine compounds. Toxicol Lett. 1980;5:1.
Article
Google Scholar
Bracken WM, Sharma RP, Kleinschuster SJ. The effects of select neurotoxic chemicals on synaptosomal monoamine uptake and K + −dependent phosphatase. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1981;1(6):432–6.
Article
CAS
Google Scholar
Bansal SK, Desaiah D. Effects of chlordecone and its structural analogs on p-nitrophenyl phosphatase. Toxicol Lett. 1982;12(2–3):83–90.
Article
CAS
Google Scholar
Chetty SC, Aldous CN, Rashatwar SS, Desaiah D. Effect of chlordecone on pH and temperature dependent substrate activation kinetics of rat brain synaptosomal ATPases. Biochem Pharmacol. 1983;32(21):3205–11.
Article
CAS
Google Scholar
Bansal SK, Desaiah D. Chlordecone toxicity: effect of withdrawal of treatment on ATPase inhibition. Neurotoxicology. 1985;6(3):103–7.
CAS
Google Scholar
Desaiah D, Chetty CS, Rao KS. Chlordecone inhibition of calmodulin activated calcium ATPase in rat brain synaptosomes. J Toxicol Environ Health. 1985;16(2):189–95. doi:10.1080/15287398509530732.
Article
CAS
Google Scholar
Jinna RR, Uzodinma JE, Desaiah D. Age-related changes in rat brain ATPases during treatment with chlordecone. J Toxicol Environ Health. 1989;27(2):199–208. doi:10.1080/15287398909531291.
Article
CAS
Google Scholar
Uzodinma JE, Desaiah D. Age-Related Changes in Rat Brain ATPases during Treatment with Chlordecone. J Toxicol Environ Health. 1989;27(2):199–208.
Article
Google Scholar
Maier WE, Costa LG. Sodium, potassium-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: Studies with chlordecone, organotins and mercury compounds. Toxicol Lett. 1990;51(2):175–88.
Article
CAS
Google Scholar
Chang-Tsui YYH, Ho IK. Effects of Kepone (chlordecone) on synaptosomal g-aminobutyric acid uptake in the mouse. Neurotoxicology. 1979;1(2):357–67.
CAS
Google Scholar
Hwang EC, Van Woert MH. Serotonin-norepinephrine interactions in the tremorolytic actions of phenoxybenzamine and trazodone. Pharmacol Biochem Behav. 1979;10(1):27–9.
Article
CAS
Google Scholar
Baggett JM, Thureson-Klein A, Klein RL. Effects of chlordecone on the adrenal medulla of the rat. Toxicol Appl Pharmacol. 1980;52(2):313–22.
Article
CAS
Google Scholar
Chang-Tsui YYH, Ho IK. Effect of Kepone (chlordecone) on synaptosomal catecholamine uptake in the mouse. Neurotoxicology. 1980;1(3):643–51.
CAS
Google Scholar
Seth PK, Agrawal AK, Bondy SC. Biochemical changes in the brain consequent to dietary exposure of developing and mature rats to chlordecone (kepone). Toxicol Appl Pharmacol. 1981;59(2):262–7.
Article
CAS
Google Scholar
Ali SF, Hong JS, Wilson WE, Lamb JC, Moore JA, Mason GA, et al. Subchronic dietary exposure of rats to chlordecone (Kepone) modifies levels of hypothalamic beta-endorphin. Neurotoxicology. 1982;3(2):119–24.
CAS
Google Scholar
Fujimori K, Nabeshima T, Ho IK, Mehendale HM. Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice. Neurotoxicology. 1982;3(2):143–8.
CAS
Google Scholar
Gerhart JM, Hong JS, Tilson HA. The possible sites of chlordecone-induced tremor in rats. Toxicol Appl Pharmacol. 1983;70(3):382–9.
Article
CAS
Google Scholar
Aldous CN, Chetty CS, Mehendale HM, Desaiah D. Lack of effects of chlordecone on synthesis rates, steady state levels and metabolites of catecholamines in rat brain. Neurotoxicology. 1984;5(2):59–65.
CAS
Google Scholar
Gandolfi O, Cheney DL, Hong JS, Costa E. On the neurotoxicity of chlordecone: a role for gamma-aminobutyric acid and serotonin. Brain Res. 1984;303(1):117–23.
Article
CAS
Google Scholar
Hong JS, Tilson HA, Uphouse LL, Gerhart J, Wilson WE. Effects of chlordecone exposure on brain neurotransmitters: possible involvement of the serotonin system in chlordecone-elicited tremor. Toxicol Appl Pharmacol. 1984;73(2):336–44.
Article
CAS
Google Scholar
Hudson PM, Yoshikawa K, Ali SF, Lamb JC, Reel JR, Hong JS. Estrogen-like activity of chlordecone (kepone) on the hypothalamo-pituitary axis: effects on the pituitary enkephalin system. Toxicol Appl Pharmacol. 1984;74(3):383–9.
Article
CAS
Google Scholar
Desaiah D. Chlordecone interaction with catecholamine binding and uptake in rat brain synaptosomes. Neurotoxicology. 1985;6(1):159–65.
CAS
Google Scholar
Bloomquist JR, Adams PM, Soderlund DM. Inhibition of gamma-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides. Neurotoxicology. 1986;7(3):11–20.
CAS
Google Scholar
Fujimori K, Benet H, Mehendale HM, Ho IK. In vivo and in vitro synthesis, release, and uptake of [3-H]-dopamine in mouse striatal slices after in vivo exposure to chlordecone. J Biochem Toxicol. 1986;1(4):1–12.
Article
CAS
Google Scholar
Tilson HA, Hudson PM, Hong JS. 5,5-Diphenylhydantoin antagonizes neurochemical and behavioral effects of p, p’-DDT but not of chlordecone. J Neurochem. 1986;47(6):1870–8.
Article
CAS
Google Scholar
Uphouse L, Eckols K. Serotonin receptors in striatum after chlordecone treatment of adult female rats. Neurotoxicology. 1986;7(1):25–32.
CAS
Google Scholar
Carr RL, Couch TA, Liu J, Coats JR, Chambers JE. The interaction of chlorinated alicyclic insecticides with brain GABAA receptors in channel catfish (Ictalurus punctatus). J Toxic Environ Health A. 1999;56(8):543–53.
CAS
Google Scholar
Hoskins B, Ho IK. Chlordecone-induced alterations in content and subcellular distribution of calcium in mouse brain. J Toxicol Environ Health. 1982;9(4):535–44. doi:10.1080/15287398209530186.
Article
CAS
Google Scholar
Komulainen H, Bondy SC. Modulation of levels of free calcium within synaptosomes by organochlorine insecticides. J Pharmacol Exp Ther. 1987;241(2):575–81.
CAS
Google Scholar
Bondy SC, Halsall LC. GM1 ganglioside enhances synaptosomal resistance to chemically induced damage. Neurosci Lett. 1988;84(2):229–33.
Article
CAS
Google Scholar
Bondy SC, Komulainen H. Intracellular Calcium as an Index of Neurotoxic Damage. Toxicology. 1988;49(1):35–41.
Article
CAS
Google Scholar
Bondy SC, McKee M. Prevention of chemically induced synaptosomal changes. J Neurosci Res. 1990;25(2):229–35. doi:10.1002/jnr.490250211.
Article
CAS
Google Scholar
Inoue K, Nakazawa K, Obama T, Fujimori K, Takanaka A. Chlordecone Inhibits Three Types of Ion Channels in a Neural Cell Line. Pharmacol Toxicol. 1991;67(5):444–6.
Article
Google Scholar
Cheng D, Bedford MT. Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem : a European journal of chemical biology. 2011;12(2):323–9. doi:10.1002/cbic.201000522.
Article
CAS
Google Scholar
Benachour N, Moslemi S, Sipahutar H, Seralini GE. Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007;222(2):129–40. doi:10.1016/j.taap.2007.03.033.
Article
CAS
Google Scholar
Bjárge C, Brunborg G, Wiger R, Holme JA, Scholz T, Dybing E, et al. A comparative study of chemically induced DNA damage in isolated human and rat testicular cells. Reprod Toxicol. 1996;10(6):509–19.
Article
Google Scholar
Caldwell V, Loch-Caruso R. Chlordecone rapidly and reversibly inhibits gap junctional communication in human embryonic palatal mesenchyme cells. In Vitro Toxicol. 1992;5(2):113–22.
CAS
Google Scholar
Starcevic SL, Bortolin S, Woodcroft KJ, Novak RF. Kepone (chlordecone) disrupts adherens junctions in human breast epithelial cells cultured on matrigel. In vivo. 2001;15(4):289–94.
CAS
Google Scholar
Li X, Zhang S, Safe S. Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. J Steroid Biochem Mol Biol. 2006;98(2–3):122–32. doi:10.1016/j.jsbmb.2005.08.018.
Article
CAS
Google Scholar
Ikegwuonu FI, Mehendale HM. Biochemical assessment of the genotoxicity of the in vitro interaction between chlordecone and carbon tetrachloride in rat hepatocytes. J Appl Toxicol. 1991;11(4):303–10.
Article
CAS
Google Scholar
Moser GJ, Smart RC. Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity. Carcinogenesis. 1989;10(5):851–6.
Article
CAS
Google Scholar
Rotenberg SA, Weinstein IB. Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium. Mol Carcinog. 1991;4(6):477–81.
Article
CAS
Google Scholar
Tsushimoto G, Trosko JE, Chang CC, Matsumura F. Inhibition of intercellular communication by chlordecone (kepone) and mirex in Chinese hamster V79 cells in vitro. Toxicol Appl Pharmacol. 1982;64(3):550–6.
Article
CAS
Google Scholar
Clere N, Lauret E, Malthiery Y, Andriantsitohaina R, Faure S. Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis. Angiogenesis. 2012;15(4):745–60. doi:10.1007/s10456-012-9288-7.
Article
CAS
Google Scholar
Skalsky HL, Fariss MW, Blanke RV, Guzelian PS. The role of plasma proteins in the transport and distribution of chlordecone (Kepone) and other polyhalogenated hydrocarbons. Ann N Y Acad Sci. 1979;320:231–7.
Article
CAS
Google Scholar
Rosecrans JA, Johnson JH, Tilson HA, Hong JS. Hypothalamic-pituitary adrenal (HPAA) axis function in adult Fischer-344 rats exposed during development to neurotoxic chemicals perinatally. Neurobehav Toxicol Teratol. 1984;6(4):281–8.
CAS
Google Scholar
Rosecrans JA, Squibb Jr RE, Johnson JH, Tilson HA, Hong JS. Effects Of Neonatal Chlordecone Exposure On Pituitary-Adrenal Function In Adult Fischer-344-Rats. Neurobehav Toxicol Teratol. 1985;7(1):33–7.
CAS
Google Scholar
Rosenstein L, Brice A, Rogers N, Lawrence S. Neurotoxicity of kepone in perinatal rats following in utero exposure. Toxicol Appl Pharmacol. 1977;41(1):142–3.
Google Scholar
Squibb RE, Tilson HA. Effects of gestational and perinatal exposure to chlordecone (Kepone) on the neurobehavioral development of Fischer-344 rats. Neurotoxicology. 1982;3(2):17–26.
CAS
Google Scholar
AFSSA. Avis de l’Agence française de sécurité sanitaire des aliments relatif à l’actualisation des données scientifiques sur la toxicité du chlordécone en vue d’une éventuelle révision des limites tolérables d’exposition proposées par l’Afssa en 2003. final. Maisons-Alfort: Agence Française de Sécurité Sanitaire des Aliments; 2007.
Google Scholar
Reuber MD. Carcinomas of the liver in rats ingesting kepone. Neoplasma. 1979;26(2):231–5.
CAS
Google Scholar
AFSSA. Avis de l’Agence française de sécurité sanitaire des aliments relatif à l’évaluation des risques liés à la consommation de denrées alimentaires contaminées par la chlordécone en Martinique et en Guadeloupe. final. Maisons-Alfort: Agence Française de Sécurité Sanitaire des Aliments; 2003.
Google Scholar
Multigner L, Kadhel P. Exposition à des polluants environnementaux chez la femme enceinte et son enfant en Guadeloupep Niveaux de chlordécone dans le sang maternel et étude des déterminants de l’imprégnation. Inserm U625 & Service Gynécologie-obstétrique CHU Pointe-à-Pitre, Pointe-à-Pitre. 2004.
Guldner L, Seurin S, Héraud F, Multignier L. Exposition de la population antillaise au chlordécone. Numéro thématique – Chlordécone aux Antilles : bilan actualisé des risques sanitaires BEH. 2011;3-4-5:25–8.
Google Scholar
Joachim C, Macni J, Véronique-Baudin J, Piccotti C, Escarmant P. Epidémiologie du cancer de la prostate aux Antilles-Guyane : données des registres généraux des cancers. BVS. 2013;8–9:3–5.
Google Scholar
Giusti A, Lagadic L, Barsi A, Thome JP, Joaquim-Justo C, Ducrot V. Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis. Sci Total Environ. 2014;493:147–55. doi:10.1016/j.scitotenv.2014.05.130.
Article
CAS
Google Scholar
Wang S, Aarts JM, De Haan LH, Argyriou D, Peijnenburg AA, Rietjens IM, et al. Towards an integrated in vitro strategy for estrogenicity testing. J Appl Toxicol. 2014;34(9):1031–40. doi:10.1002/jat.2928.
Article
CAS
Google Scholar
Bucher S, Le Vee M, Jouan E, Fardel O. Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014;28(3):119–28. doi:10.1002/jbt.21543.
Article
CAS
Google Scholar
Costa LG. The neurotoxicity of organochlorine and pyrethroid pesticides. Handb Clin Neurol. 2015;131:135–48. doi:10.1016/b978-0-444-62627-1.00009-3.
Article
Google Scholar
Gaume B, Dodet N, Thome JP, Lemoine S. Expression of biotransformation and oxidative stress genes in the giant freshwater prawn Macrobrachium rosenbergii exposed to chlordecone. Environ Sci Pollut Res Int. 2015;22(11):7991–8002. doi:10.1007/s11356-014-3134-y.
Article
CAS
Google Scholar
Saunders L, Kadhel P, Costet N, Rouget F, Monfort C, Thome JP, et al. Hypertensive disorders of pregnancy and gestational diabetes mellitus among French Caribbean women chronically exposed to chlordecone. Environ Int. 2014;68:171–6. doi:10.1016/j.envint.2014.03.024.
Article
CAS
Google Scholar
Dieye M, Banydeen R, Macni J, Michel S, Veronique-Baudin J, Sasco A, et al. Geographic variations and temporal trends in prostate cancer in Martinique over a 25-year period. BMC research notes. 2014;7:262. doi:10.1186/1756-0500-7-262.
Article
Google Scholar
Kadhel P, Monfort C, Costet N, Rouget F, Thome JP, Multigner L, et al. Chlordecone exposure, length of gestation, and risk of preterm birth. Am J Epidemiol. 2014;179(5):536–44. doi:10.1093/aje/kwt313.
Article
Google Scholar
Cordier S, Bouquet E, Warembourg C, Massart C, Rouget F, Kadhel P, et al. Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies). Environ Res. 2015;138:271–8. doi:10.1016/j.envres.2015.02.021.
Article
CAS
Google Scholar
Costet N, Pele F, Comets E, Rouget F, Monfort C, Bodeau-Livinec F, et al. Perinatal exposure to chlordecone and infant growth. Environ Res. 2015;142:123–34. doi:10.1016/j.envres.2015.06.023.
Article
CAS
Google Scholar
Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, De Cerain L, Salsamendi A, et al. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015;36(1):S254–S96. doi:10.1093/carcin/bgv039.
Article
CAS
Google Scholar
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee D-H, et al. Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses. Endocr Rev. 2012;33(3):378–455. doi:10.1210/er.2011-1050.
Article
CAS
Google Scholar
Wang F, Roberts SM, Butfiloski EJ, Morel L, Sobel ES. Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice. Toxicol Sci. 2007;99(1):141–52.
Article
CAS
Google Scholar