Articles

Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis

Epidemiologic studies have raised the possibility that some pesticide compounds induce the neurodegenerative disease amyotrophic lateral sclerosis (ALS), though the available evidence is not entirely consistent.

Authors: Marco Vinceti, Tommaso Filippini, Federica Violi, Kenneth J. Rothman, Sofia Costanzini, Carlotta Malagoli, Lauren A. Wise, Anna Odone, Carlo Signorelli, Laura Iacuzio, Elisa Arcolin, Jessica Mandrioli, Nicola Fini, Francesco Patti, Salvatore Lo Fermo, Vladimiro Pietrini…

Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study

Brain tumor etiology is poorly understood. Based on their ability to pass through the blood–brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from t...

Authors: Marie-Elise Parent, Michelle C. Turner, Jérôme Lavoué, Hugues Richard, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Geza Benke, Maria Blettner, Sarah Fleming, Martine Hours, Daniel Krewski, David McLean, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer…

Ambient ultraviolet radiation exposure and hepatocellular carcinoma incidence in the United States

Hepatocellular carcinoma (HCC), the most commonly occurring type of primary liver cancer, has been increasing in incidence worldwide. Vitamin D, acquired from sunlight exposure, diet, and dietary supplements, ...

Authors: Trang VoPham, Kimberly A. Bertrand, Jian-Min Yuan, Rulla M. Tamimi, Jaime E. Hart and Francine Laden

Genetic and epigenetic susceptibility of airway inflammation to PM_2.5 in school children: new insights from quantile regression

The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that has proved to be useful in investigations of genetic and epigenetic airway susceptibility to ambient air p...

Authors: Yue Zhang, Muhammad T. Salam, Kiros Berhane, Sandrah P. Eckel, Edward B. Rappaport, William S. Linn, Rima Habre, Theresa M. Bastain and Frank D. Gilliland

Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

Due to their lack of repair capacity mitochondria are critical targets for environmental toxicants. We studied genes and pathways reflecting mitochondrial responses to short- and medium-term PM₁₀ exposure.

Authors: Ellen Winckelmans, Tim S Nawrot, Maria Tsamou, Elly Den Hond, Willy Baeyens, Jos Kleinjans, Wouter Lefebvre, Nicolas Van Larebeke, Martien Peusens, Michelle Plusquin, Hans Reynders, Greet Schoeters, Charlotte Vanpoucke, Theo M de Kok and Karen Vrijens

Incidence of cancer among licenced commercial pilots flying North Atlantic routes

To evaluate cancer incidence among licenced commercial pilots in association with cosmic radiation.

Authors: Eva Maria Gudmundsdottir, Jon Hrafnkelsson and Vilhjalmur Rafnsson

The hazards of hazard identification in environmental epidemiology

Hazard identification is a major scientific challenge, notably for environmental epidemiology, and is often surrounded, as the recent case of glyphosate shows, by debate arising in the first place by the inher...

Authors: Rodolfo Saracci

Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study

To examine the relationship between cadmium, lead, and mercury concentrations with high-sensitivity C-reactive protein (hs-CRP) and homocysteine in women.

Authors: Anna Z. Pollack, Sunni L. Mumford, Lindsey Sjaarda, Neil J. Perkins, Farah Malik, Jean Wactawski-Wende and Enrique F. Schisterman

Maternal occupational exposure and oral clefts in offspring

Previous studies suggest that periconceptional maternal occupational exposure to solvents and pesticides increase the risk of oral clefts in the offspring. Less is known about the effect of occupational exposu...

Authors: Nynke Spinder, Jorieke E. H. Bergman, H. Marike Boezen, Roel C. H. Vermeulen, Hans Kromhout and Hermien E. K. de Walle

Does air pollution play a role in infertility?: a systematic review

Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxyg...

Authors: Julie Carré, Nicolas Gatimel, Jessika Moreau, Jean Parinaud and Roger Léandri

Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

Neurodevelopment is a complex process involving both genetic and environmental factors. Prenatal exposure to lead (Pb) has been associated with lower performance on neurodevelopmental tests. Adverse neurodevel...

Authors: Zhaoxi Wang, Birgit Claus Henn, Chaolong Wang, Yongyue Wei, Li Su, Ryan Sun, Han Chen, Peter J. Wagner, Quan Lu, Xihong Lin, Robert Wright, David Bellinger, Molly Kile, Maitreyi Mazumdar, Martha Maria Tellez-Rojo, Lourdes Schnaas…

Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study

Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.

Authors: Maohua Miao, Ziliang Wang, Xiaoqin Liu, Hong Liang, Zhijun Zhou, Hui Tan, Wei Yuan and De-Kun Li

Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social ...

Authors: Youn-Hee Lim, Sanghyuk Bae, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim and Yun-Chul Hong

Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case–control study

Noise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study explored the relationship between the genetic variations in the CASP gene and the risk of develo...

Authors: Yinyin Wu, Juntao Ni, Mingjian Qi, Chengjian Cao, Yuxian Shao, Liangwen Xu, Haiyan Ma and Lei Yang

Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study w...

Authors: Christine Barul, Aurore Fayossé, Matthieu Carton, Corinne Pilorget, Anne-Sophie Woronoff, Isabelle Stücker and Danièle Luce

Ambulatory monitoring demonstrates an acute association between cookstove-related carbon monoxide and blood pressure in a Ghanaian cohort

Repeated exposure to household air pollution may intermittently raise blood pressure (BP) and affect cardiovascular outcomes. We investigated whether hourly carbon monoxide (CO) exposures were associated with ...

Authors: Ashlinn K. Quinn, Kenneth Ayuurebobi Ae-Ngibise, Patrick L. Kinney, Seyram Kaali, Blair J. Wylie, Ellen Boamah, Daichi Shimbo, Oscar Agyei, Steven N. Chillrud, Mohammed Mujtaba, Joseph E. Schwartz, Marwah Abdalla, Seth Owusu-Agyei, Darby W. Jack and Kwaku Poku Asante

Association between genome-wide copy number variation and arsenic-induced skin lesions: a prospective study

Exposure to arsenic in drinking water is a global health problem and arsenic-induced skin lesions are hallmark of chronic arsenic toxicity. We and others have reported germline genetic variations as risk facto...

Authors: Muhammad G. Kibriya, Farzana Jasmine, Faruque Parvez, Maria Argos, Shantanu Roy, Rachelle Paul-Brutus, Tariqul Islam, Alauddin Ahmed, Muhammad Rakibuz-Zaman, Justin Shinkle, Vesna Slavkovich, Joseph H. Graziano and Habibul Ahsan

A systematic comparison of statistical methods to detect interactions in exposome-health associations

There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality o...

Authors: Jose Barrera-Gómez, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Lise Giorgis-Allemand, Valérie Siroux, Oliver Robinson, Jelle Vlaanderen, Juan R. González, Mark Nieuwenhuijsen, Paolo Vineis, Martine Vrijheid, Roel Vermeulen, Rémy Slama and Xavier Basagaña

The effect of ambient temperature on type-2-diabetes: case-crossover analysis of 4+ million GP consultations across England

Given the double jeopardy of global increases in rates of obesity and climate change, it is increasingly important to recognise the dangers posed to diabetic patients during periods of extreme weather. We aime...

Authors: S. Hajat, A. Haines, C. Sarran, A. Sharma, C. Bates and L. E. Fleming

Desert dust outbreaks and respiratory morbidity in Athens, Greece

Ambient particulate matter (PM) has an adverse effect on respiratory morbidity. Desert dust outbreaks contribute to increased PM levels but the toxicity of desert dust mixed with anthropogenic pollutants needs...

Authors: Stavroula-Myrto Trianti, Evangelia Samoli, Sophia Rodopoulou, Klea Katsouyanni, Spyros A. Papiris and Anna Karakatsani

The association between ambient fine particulate matter and incident adenocarcinoma subtype of lung cancer

Adenocarcinoma (AC) is the most common lung cancer among non-smokers, but few studies have assessed the effect of PM_2.5 on AC among never smokers. The purpose of this study was to assess the association between a...

Authors: Lida Gharibvand, W. Lawrence Beeson, David Shavlik, Raymond Knutsen, Mark Ghamsary, Samuel Soret and Synnove F. Knutsen

Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures

Ionizing radiation is a well-known carcinogen. Chromosome aberrations, and in particular micronuclei represent an early biological predictor of cancer risk. There are well-documented associations of micronucle...

Authors: D. Bazyka, S. C. Finch, I. M. Ilienko, O. Lyaskivska, I. Dyagil, N. Trotsiuk, N. Gudzenko, V. V. Chumak, K. M. Walsh, J. Wiemels, M. P. Little and L.B. Zablotska

Ancient water bottle use and polycyclic aromatic hydrocarbon (PAH) exposure among California Indians: a prehistoric health risk assessment

Polycyclic aromatic hydrocarbons (PAHs) are the main toxic compounds in natural bitumen, a fossil material used by modern and ancient societies around the world. The adverse health effects of PAHs on modern hu...

Authors: Sabrina B. Sholts, Kevin Smith, Cecilia Wallin, Trifa M. Ahmed and Sebastian K. T. S. Wärmländer

Impact of phthalate and BPA exposure during in utero windows of susceptibility on reproductive hormones and sexual maturation in peripubertal males

Phthalates and BPA are endocrine disrupting chemicals (EDCs) widely used in consumer products. Evidence suggests that phthalate and BPA exposure alters steroid hormone levels in adults, while in utero exposure...

Authors: Deborah J. Watkins, Brisa N. Sánchez, Martha Maria Téllez-Rojo, Joyce M. Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E. Peterson and John D. Meeker

Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study

Vaginal candidiasis is frequent among pregnant women and it is treated with anti-fungal medication (conazoles). Conazoles have anti-androgenic properties and prenatal exposure in rodents is associated with a s...

Authors: Djamilla Madelung Mogensen, Maria Bergkvist Pihl, Niels E. Skakkebæk, Helle Raun Andersen, Anders Juul, Henriette Boye Kyhl, Shanna Swan, David Møbjerg Kristensen, Marianne Skovager Andersen, Dorte Vesterholm Lind and Tina Kold Jensen

Erratum to: Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review

Authors: Mathieu Valcke, Marie-Eve Levasseur, Agnes Soares da Silva and Catharina Wesseling

A re-assessment of the safety of silver in household water treatment: rapid systematic review of mammalian in vivo genotoxicity studies

Despite poor evidence of their effectiveness, colloidal silver and silver nanoparticles are increasingly being promoted for treating potentially contaminated drinking water in low income countries. Recently, h...

Authors: Lorna Fewtrell, Batsirai Majuru and Paul R. Hunter

Household cereal crop harvest and children’s nutritional status in rural Burkina Faso

Reduction of child undernutrition is one of the Sustainable Development Goals for 2030. Achievement of this goal may be made more difficult in some settings by climate change through adverse impact on agricult...

Authors: Kristine Belesova, Antonio Gasparrini, Ali Sié, Rainer Sauerborn and Paul Wilkinson

Long-term exposure to ambient ultrafine particles and respiratory disease incidence in in Toronto, Canada: a cohort study

Little is known about the long-term health effects of ambient ultrafine particles (<0.1 μm) (UFPs) including their association with respiratory disease incidence. In this study, we examined the relationship be...

Authors: Scott Weichenthal, Li Bai, Marianne Hatzopoulou, Keith Van Ryswyk, Jeffrey C. Kwong, Michael Jerrett, Aaron van Donkelaar, Randall V. Martin, Richard T. Burnett, Hong Lu and Hong Chen

Erratum to: Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach

Authors: Cassandra R. O’ Lenick, Howard H. Chang, Michael R. Kramer, Andrea Winquist, James A. Mulholland, Mariel D. Friberg and Stefanie Ebelt Sarnat

Use of mobile and cordless phones and change in cognitive function: a prospective cohort analysis of Australian primary school children

Some previous studies have suggested an association between children’s use of mobile phones (MPs)/cordless phones (CPs) and development of cognitive function. We evaluated possible longitudinal associations be...

Authors: Chhavi Raj Bhatt, Geza Benke, Catherine L. Smith, Mary Redmayne, Christina Dimitriadis, Anna Dalecki, Skye Macleod, Malcolm R. Sim, Rodney J. Croft, Rory Wolfe, Jordy Kaufman and Michael J. Abramson

Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults

Daily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnera...

Authors: Luc Int Panis, Eline B Provost, Bianca Cox, Tijs Louwies, Michelle Laeremans, Arnout Standaert, Evi Dons, Luc Holmstock, Tim Nawrot and Patrick De Boever

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist du...

Authors: Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas and David J. Robbins

Air pollution, cardiovascular endpoints and susceptibility by stress and material resources: a systematic review of the evidence

Evidence shows that both the physical and social environments play a role in the development of cardiovascular disease. The purpose of this systematic review is two-fold: First, we summarize research from the ...

Authors: Christina H. Fuller, Karla R. Feeser, Jeremy A. Sarnat and Marie S. O’Neill

Household air pollution from cooking and risk of adverse health and birth outcomes in Bangladesh: a nationwide population-based study

Household air pollution (HAP) from cooking with solid fuels has become a leading cause of death and disability in many developing countries including Bangladesh. We assess the association between HAP and risk ...

Authors: Md Nuruzzaman Khan, Cherri Zhang B. Nurs, M. Mofizul Islam, Md Rafiqul Islam and Md Mizanur Rahman

Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

Environmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast ...

Authors: Maria Wielsøe, Peder Kern and Eva Cecilie Bonefeld-Jørgensen

Comparison of methods for calculating the health costs of endocrine disrupters: a case study on triclosan

Socioeconomic analysis is currently used in the Europe Union as part of the regulatory process in Regulation Registration, Evaluation and Authorisation of Chemicals (REACH), with the aim of assessing and manag...

Authors: Radka Prichystalova, Jean-Baptiste Fini, Leonardo Trasande, Martine Bellanger, Barbara Demeneix and Laura Maxim

The short term burden of ambient fine particulate matter on chronic obstructive pulmonary disease in Ningbo, China

Numerous studies have found associations between ambient fine particulate matter (PM_2.5) and increased mortality risk. However, little evidence is available on associations between PM_2.5 and years of life lost (Y...

Authors: Guoxing Li, Jing Huang, Guozhang Xu, Xiaochuan Pan, Xujun Qian, Jiaying Xu, Yan Zhao, Tao Zhang, Qichen Liu, Xinbiao Guo and Tianfeng He

Blood pressure in young adulthood and residential greenness in the early-life environment of twins

Previous research shows that, besides risk factors in adult life, the early-life environment can influence blood pressure and hypertension in adults. However, the effects of residential traffic exposure and re...

Authors: Esmée M Bijnens, Tim S Nawrot, Ruth JF Loos, Marij Gielen, Robert Vlietinck, Catherine Derom and Maurice P Zeegers

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort

Air pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-t...

Authors: Ellen Winckelmans, Karen Vrijens, Maria Tsamou, Bram G. Janssen, Nelly D. Saenen, Harry A. Roels, Jos Kleinjans, Wouter Lefebvre, Charlotte Vanpoucke, Theo M. de Kok and Tim S. Nawrot

Mobile phone use, school electromagnetic field levels and related symptoms: a cross-sectional survey among 2150 high school students in Izmir

Health outcomes of electromagnetic fields (EMF) from mobile phones and their base stations are of concern. Conducting multidisciplinary research, targeting children and exploring dose-response are recommended....

Authors: Raika Durusoy, Hür Hassoy, Ahmet Özkurt and Ali Osman Karababa

Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life

In utero arsenic exposure may alter fetal developmental programming by altering DNA methylation, which may result in a higher risk of disease in later life. We evaluated the association between in utero arseni...

Authors: Akhilesh Kaushal, Hongmei Zhang, Wilfried J. J. Karmaus, Todd M. Everson, Carmen J. Marsit, Margaret R. Karagas, Shih-Fen Tsai, Hui-Ju Wen and Shu-Li Wang

Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review

The main causes of chronic kidney disease (CKD) globally are diabetes and hypertension but epidemics of chronic kidney disease of unknown etiology (CKDu) occur in Central America, Sri Lanka, India and beyond. ...

Authors: Mathieu Valcke, Marie-Eve Levasseur, Agnes Soares da Silva and Catharina Wesseling

Human biomonitoring from an environmental justice perspective: supporting study participation of women of Turkish and Moroccan descent

Environmental justice research shows how socially disadvantaged groups are more exposed and more vulnerable to environmental pollution. At the same time, these groups are less represented and, thus, less visib...

Authors: Bert Morrens, Elly Den Hond, Greet Schoeters, Dries Coertjens, Ann Colles, Tim S. Nawrot, Willy Baeyens, Stefaan De Henauw, Vera Nelen and Ilse Loots

Prenatal bisphenol a exposure and dysregulation of infant hypothalamic-pituitary-adrenal axis function: findings from the APrON cohort study

Animal models show that prenatal bisphenol A (BPA) exposure leads to sexually dimorphic disruption of the neuroendocrine system in offspring, including the hypothalamic-pituitary-adrenal (HPA) neuroendocrine s...

Authors: Gerald F Giesbrecht, Maede Ejaredar, Jiaying Liu, Jenna Thomas, Nicole Letourneau, Tavis Campbell, Jonathan W Martin and Deborah Dewey

Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study

Prenatal exposure to organophosphate pesticides (OPs) has been associated with impaired child development. Pesticide exposure determinants need to be studied in order to identify sources and pathways of pestic...

Authors: Sabrina Llop, Mario Murcia, Carmen Iñiguez, Marta Roca, Llúcia González, Vicent Yusà, Marisa Rebagliato and Ferran Ballester

Monitoring urban beaches with qPCR vs. culture measures of fecal indicator bacteria: Implications for public notification

The United States Environmental Protection Agency has established methods for testing beach water using the rapid quantitative polymerase chain reaction (qPCR) method, as well as “beach action values” so that ...

Authors: Samuel Dorevitch, Abhilasha Shrestha, Stephanie DeFlorio-Barker, Cathy Breitenbach and Ira Heimler

A chronology of ratios between black smoke and PM₁₀ and PM_2.5 in the context of comparison of air pollution epidemiology concentration-response functions

For many air pollution epidemiological studies in Europe, ‘black smoke’ (BS) was the only measurement available to quantify ambient particulate matter (PM), particularly for exposures prior to the mid-1990s wh...

Authors: Mathew R. Heal and Iain J. Beverland

Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice

Children are at daily risk for exposure to organophosphate insecticides, of which the most common is chlorpyrifos (CPF). Exposure of pregnant women to CPF was linked to decreased birth weight, abnormal reflexe...

Authors: Anat Lan, Michal Kalimian, Benjamin Amram and Ora Kofman

Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco- and menthol-flavored e-cigarettes

We aimed to assess the content of electronic cigarette (EC) emissions for five groups of potentially toxic compounds that are known to be present in tobacco smoke: nicotine, particles, carbonyls, volatile orga...

Authors: Mi-Sun Lee, Ryan F. LeBouf, Youn-Suk Son, Petros Koutrakis and David C. Christiani